Irinotecan (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.106978
SRRM2 serine/arginine repetitive matrix 2 0.096081
PLEC plectin 0.0900793
KRT18 keratin 18, type I 0.0892554
NACA nascent polypeptide-associated complex alpha subunit 0.0699195
HSPA8 heat shock 70kDa protein 8 0.0694523
MYH9 myosin, heavy chain 9, non-muscle 0.0665734
TPM3 tropomyosin 3 0.0630715
EIF1 eukaryotic translation initiation factor 1 0.0618472
EEF2 eukaryotic translation elongation factor 2 0.0601943
ADAR adenosine deaminase, RNA-specific 0.0579227
RBM33 RNA binding motif protein 33 0.055507
CAMTA1 calmodulin binding transcription activator 1 0.0544989
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0524206
ANKRD11 ankyrin repeat domain 11 0.0521798
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0519819
NCAPD2 non-SMC condensin I complex, subunit D2 0.0519487
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0516261
OGA O-GlcNAcase 0.0499689
PFKP phosphofructokinase, platelet 0.0495775
CEP250 centrosomal protein 250kDa 0.0495438
TPI1 triosephosphate isomerase 1 0.0480539
RPL11 ribosomal protein L11 0.0468692
KMT2D lysine (K)-specific methyltransferase 2D 0.0468143
SMAD3 SMAD family member 3 0.04665
NUMA1 nuclear mitotic apparatus protein 1 0.0464839
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0453572
SND1 staphylococcal nuclease and tudor domain containing 1 0.0452711
SAMD4A sterile alpha motif domain containing 4A 0.0451246
BBX bobby sox homolog (Drosophila) 0.045078
PRRC2A proline-rich coiled-coil 2A 0.0446014
ZNF638 zinc finger protein 638 0.0444988
RPL13A ribosomal protein L13a 0.0440902
ANKRD36 ankyrin repeat domain 36 0.0436019
IQGAP3 IQ motif containing GTPase activating protein 3 0.0430941
EIF4B eukaryotic translation initiation factor 4B 0.0425701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0414389
HLA-B major histocompatibility complex, class I, B 0.0410115
COPA coatomer protein complex, subunit alpha 0.0409988
RPL37A ribosomal protein L37a 0.0408165
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0401498
RAD51B RAD51 paralog B 0.0398192
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0397563
KDM4B lysine (K)-specific demethylase 4B 0.0392096
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0389855
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0386508
CTTN cortactin 0.0383495
ZCCHC7 zinc finger, CCHC domain containing 7 0.0379832
FAM168A family with sequence similarity 168, member A 0.0377108
PTK2 protein tyrosine kinase 2 0.0377065
AKAP9 A kinase (PRKA) anchor protein 9 0.037477
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373782
DIDO1 death inducer-obliterator 1 0.0373241
DCAF8 DDB1 and CUL4 associated factor 8 0.0369291
WNK1 WNK lysine deficient protein kinase 1 0.0367346
PER1 period circadian clock 1 0.0363204
NCOR2 nuclear receptor corepressor 2 0.0363065
EIF4H eukaryotic translation initiation factor 4H 0.0362309
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0360971
SHB Src homology 2 domain containing adaptor protein B 0.0358059
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0355731
SETD5 SET domain containing 5 0.0354673
RPL26 ribosomal protein L26 0.0354176
RPS12 ribosomal protein S12 0.034703
CMIP c-Maf inducing protein 0.0344857
RPL3 ribosomal protein L3 0.0342235
GOLGA4 golgin A4 0.0341505
ZFAND3 zinc finger, AN1-type domain 3 0.0340506
UBE2H ubiquitin-conjugating enzyme E2H 0.0337775
LOC112694756 uncharaterized LOC112694756 0.0334858
ZBTB25 zinc finger and BTB domain containing 25 0.0332469
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0332337
RPL37 ribosomal protein L37 0.0332245
AGRN agrin 0.0329999
MKI67 marker of proliferation Ki-67 0.032903
COPG1 coatomer protein complex, subunit gamma 1 0.0328236
ESYT2 extended synaptotagmin-like protein 2 0.032768
PNN pinin, desmosome associated protein 0.032696
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0325604
TRIO trio Rho guanine nucleotide exchange factor 0.0322661
RPS6 ribosomal protein S6 0.0319014
GSE1 Gse1 coiled-coil protein 0.0317156
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0316316
PRKCE protein kinase C, epsilon 0.0313352
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0312325
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0311508
EXOC6B exocyst complex component 6B 0.0308255
MEF2D myocyte enhancer factor 2D 0.0308091
C6ORF62 chromosome 6 open reading frame 62 0.030686
NUDCD3 NudC domain containing 3 0.0302613
RPL4 ribosomal protein L4 0.0302606
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0301218
BRD2 bromodomain containing 2 0.030121
FLNA filamin A, alpha 0.0299064
ASXL2 additional sex combs like transcriptional regulator 2 0.0297151
RPL19 ribosomal protein L19 0.0296738
RNF216 ring finger protein 216 0.0295015
MPRIP myosin phosphatase Rho interacting protein 0.0294393
BRD4 bromodomain containing 4 0.0293624
MIDEAS mitotic deacetylase associated SANT domain protein 0.0293049

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.227959
TFPI2 tissue factor pathway inhibitor 2 -0.180436
VIM vimentin -0.135087
TXNRD1 thioredoxin reductase 1 -0.114489
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.111905
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111759
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109581
UBC ubiquitin C -0.108383
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0798304
OSMR oncostatin M receptor -0.0705894
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0647209
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0625184
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0565952
TMSB10 thymosin beta 10 -0.0562264
EML4 echinoderm microtubule associated protein like 4 -0.0554663
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0553564
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0543756
ENO1 enolase 1, (alpha) -0.0534085
RPS27A ribosomal protein S27a -0.0527954
CDK17 cyclin-dependent kinase 17 -0.0523038
VCL vinculin -0.0508831
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0490491
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0486764
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0479333
POTEF POTE ankyrin domain family, member F -0.0470495
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0458621
STC1 stanniocalcin 1 -0.0457584
THSD4 thrombospondin, type I, domain containing 4 -0.044223
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0435383
RIMS2 regulating synaptic membrane exocytosis 2 -0.0425035
TM4SF1 transmembrane 4 L six family member 1 -0.0420838
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0417532
NIPBL Nipped-B homolog (Drosophila) -0.0412128
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0408165
NCOA7 nuclear receptor coactivator 7 -0.0397386
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0376785
AHNAK AHNAK nucleoprotein -0.0373408
ELL2 elongation factor, RNA polymerase II, 2 -0.0367992
CSNK1A1 casein kinase 1, alpha 1 -0.035814
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0355552
CCND1 cyclin D1 -0.0344338
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0343591
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0343544
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0336665
MORF4L2 mortality factor 4 like 2 -0.0320628
GNAS GNAS complex locus -0.0317982
IPO7 importin 7 -0.0317715
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0304904
KLF6 Kruppel-like factor 6 -0.0304181
TRIP12 thyroid hormone receptor interactor 12 -0.0293969
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0292415
KTN1 kinectin 1 (kinesin receptor) -0.0290597
PDE4D phosphodiesterase 4D, cAMP-specific -0.0286836
USP34 ubiquitin specific peptidase 34 -0.0284689
FBXO11 F-box protein 11 -0.0283657
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0283074
PDE10A phosphodiesterase 10A -0.027761
PLSCR1 phospholipid scramblase 1 -0.0277583
HMGA2 high mobility group AT-hook 2 -0.0272192
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0271348
VMP1 vacuole membrane protein 1 -0.0271122
CLDN1 claudin 1 -0.0270796
MYPN myopalladin -0.0269812
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0265189
RASAL2 RAS protein activator like 2 -0.0264837
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0260305
DNAH14 dynein, axonemal, heavy chain 14 -0.0258093
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0256912
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0255725
TWF1 twinfilin actin binding protein 1 -0.0254179
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0253128
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0252381
MCL1 myeloid cell leukemia 1 -0.0252368
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0249728
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0248325
IER3 immediate early response 3 -0.0244983
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0243248
IGF1R insulin-like growth factor 1 receptor -0.02417
FNDC3A fibronectin type III domain containing 3A -0.0240062
IL6ST interleukin 6 signal transducer -0.02388
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0237662
BICD1 bicaudal D homolog 1 (Drosophila) -0.023722
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0236109
VDAC1 voltage-dependent anion channel 1 -0.0234496
CD44 CD44 molecule (Indian blood group) -0.0230814
SETX senataxin -0.0228744
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0225603
ATAD2 ATPase family, AAA domain containing 2 -0.0225543
CCND2 cyclin D2 -0.022441
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0223306
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.022321
ARID4B AT rich interactive domain 4B (RBP1-like) -0.022268
ZNF217 zinc finger protein 217 -0.0221188
WWTR1 WW domain containing transcription regulator 1 -0.0220419
ANXA2 annexin A2 -0.0218086
CCDC47 coiled-coil domain containing 47 -0.0217813
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0215935
FTH1 ferritin, heavy polypeptide 1 -0.0214784
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0212559
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0212204