| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.129998 |
| GRB10 | growth factor receptor-bound protein 10 | 0.119426 |
| ACTG1 | actin gamma 1 | 0.115249 |
| PLEC | plectin | 0.112758 |
| FN1 | fibronectin 1 | 0.110835 |
| RPL23 | ribosomal protein L23 | 0.108992 |
| PGK1 | phosphoglycerate kinase 1 | 0.0947 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0898888 |
| FAM13A | family with sequence similarity 13, member A | 0.0883298 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0816601 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0765816 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0735866 |
| HLA-B | major histocompatibility complex, class I, B | 0.072555 |
| FLNB | filamin B, beta | 0.0721007 |
| KRT8 | keratin 8, type II | 0.0718822 |
| NDRG1 | N-myc downstream regulated 1 | 0.06863 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0677065 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0668491 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0660621 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0647907 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0647361 |
| VEGFA | vascular endothelial growth factor A | 0.0643878 |
| RUNX1 | runt-related transcription factor 1 | 0.0643867 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0630493 |
| TMSB4X | thymosin beta 4, X-linked | 0.0625507 |
| CD109 | CD109 molecule | 0.0608219 |
| KRT7 | keratin 7, type II | 0.0604047 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0603811 |
| RNF145 | ring finger protein 145 | 0.0595016 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0571481 |
| CALR | calreticulin | 0.0562052 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0556599 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0552814 |
| RPL4 | ribosomal protein L4 | 0.0540855 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0536966 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.052612 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0522759 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0518743 |
| LAMB3 | laminin, beta 3 | 0.0513755 |
| HLA-A | major histocompatibility complex, class I, A | 0.0512135 |
| PLAU | plasminogen activator, urokinase | 0.049744 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0496028 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0494072 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0491996 |
| OGA | O-GlcNAcase | 0.049147 |
| KRT18 | keratin 18, type I | 0.0481775 |
| RPL9 | ribosomal protein L9 | 0.0480057 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0478871 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0465187 |
| RPS3 | ribosomal protein S3 | 0.0464348 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0461756 |
| ZNF292 | zinc finger protein 292 | 0.045585 |
| NAV2 | neuron navigator 2 | 0.0452921 |
| CTBP2 | C-terminal binding protein 2 | 0.0449568 |
| RPL11 | ribosomal protein L11 | 0.0443571 |
| RPL35A | ribosomal protein L35a | 0.0442453 |
| SMAD3 | SMAD family member 3 | 0.0441143 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0438562 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0430789 |
| CCNY | cyclin Y | 0.0430785 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.042757 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0426869 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0421561 |
| RPS19 | ribosomal protein S19 | 0.0409226 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0407616 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0406223 |
| RPS12 | ribosomal protein S12 | 0.0404864 |
| COPA | coatomer protein complex, subunit alpha | 0.0403626 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0392995 |
| HELZ | helicase with zinc finger | 0.0392938 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0387241 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.038592 |
| PTK2 | protein tyrosine kinase 2 | 0.0384619 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0383345 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0371729 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0370219 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0368824 |
| TMSB10 | thymosin beta 10 | 0.0366298 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.036162 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0358764 |
| MYOF | myoferlin | 0.0356892 |
| ZNF148 | zinc finger protein 148 | 0.0354339 |
| RHOA | ras homolog family member A | 0.0351755 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0350097 |
| AHNAK | AHNAK nucleoprotein | 0.0349788 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0343425 |
| FLNA | filamin A, alpha | 0.0342779 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0338375 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0336667 |
| PCBP2 | poly(rC) binding protein 2 | 0.0335978 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0334836 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.033435 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0329083 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.032512 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0324836 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0323687 |
| RPS20 | ribosomal protein S20 | 0.03229 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.032117 |
| RPLP2 | ribosomal protein, large, P2 | 0.0317849 |
| MSI2 | musashi RNA-binding protein 2 | 0.031751 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.297167 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.239606 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.171794 |
| POTEF | POTE ankyrin domain family, member F | -0.125626 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.124911 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0901511 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0885649 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0786192 |
| CCND1 | cyclin D1 | -0.0615889 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0609768 |
| MYO6 | myosin VI | -0.0586073 |
| DTNA | dystrobrevin, alpha | -0.0581907 |
| LMO7 | LIM domain 7 | -0.0580237 |
| SDC4 | syndecan 4 | -0.0573125 |
| RPS2 | ribosomal protein S2 | -0.0567332 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0524015 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0486323 |
| DSG2 | desmoglein 2 | -0.0479315 |
| ASPH | aspartate beta-hydroxylase | -0.0467328 |
| RYBP | RING1 and YY1 binding protein | -0.038835 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0382622 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0380022 |
| S100A10 | S100 calcium binding protein A10 | -0.0379293 |
| VGLL3 | vestigial-like family member 3 | -0.0373945 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0367733 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0350317 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0347785 |
| PAPOLA | poly(A) polymerase alpha | -0.0345489 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0344478 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0343021 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.034187 |
| OSMR | oncostatin M receptor | -0.0331524 |
| CD2AP | CD2-associated protein | -0.0321753 |
| ZNF207 | zinc finger protein 207 | -0.0320732 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0318962 |
| FBXO32 | F-box protein 32 | -0.031408 |
| DSPP | dentin sialophosphoprotein | -0.030716 |
| ERBIN | erbb2 interacting protein | -0.0305663 |
| AREG | amphiregulin | -0.0305631 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.030218 |
| CANX | calnexin | -0.0293659 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0288828 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0288785 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0288214 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0274725 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0274569 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0271431 |
| TJP1 | tight junction protein 1 | -0.0270487 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0269985 |
| PLSCR1 | phospholipid scramblase 1 | -0.0267037 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.026549 |
| SP100 | SP100 nuclear antigen | -0.0263705 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0263178 |
| GOLGB1 | golgin B1 | -0.0260602 |
| GOLT1B | golgi transport 1B | -0.0260506 |
| IL6ST | interleukin 6 signal transducer | -0.0260305 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0258649 |
| FBXO11 | F-box protein 11 | -0.0254107 |
| TMEM123 | transmembrane protein 123 | -0.0250354 |
| STEAP4 | STEAP family member 4 | -0.0249278 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0249164 |
| MX2 | MX dynamin-like GTPase 2 | -0.024904 |
| MKI67 | marker of proliferation Ki-67 | -0.0247963 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0245209 |
| RASA2 | RAS p21 protein activator 2 | -0.02433 |
| USP53 | ubiquitin specific peptidase 53 | -0.0242801 |
| MYO1E | myosin IE | -0.0235035 |
| FAM3C | family with sequence similarity 3, member C | -0.0232102 |
| ANXA1 | annexin A1 | -0.023148 |
| CLTC | clathrin, heavy chain (Hc) | -0.0230967 |
| SPAG9 | sperm associated antigen 9 | -0.0228414 |
| MX1 | MX dynamin-like GTPase 1 | -0.0226278 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0222096 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0222096 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0221858 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0219914 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0217575 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0216902 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0214532 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0210949 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0210454 |
| TXNRD1 | thioredoxin reductase 1 | -0.0205749 |
| CCNL1 | cyclin L1 | -0.0205712 |
| STK17A | serine/threonine kinase 17a | -0.0205428 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0204903 |
| FTL | ferritin, light polypeptide | -0.02034 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0203337 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0202416 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0200344 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0199621 |
| HMGA1 | high mobility group AT-hook 1 | -0.0197945 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0196216 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0192561 |
| LAP3 | leucine aminopeptidase 3 | -0.0191699 |
| MED13 | mediator complex subunit 13 | -0.0191489 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0188289 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0188132 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0187298 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0187292 |
| EGR1 | early growth response 1 | -0.0184502 |
