| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0932363 |
| OGA | O-GlcNAcase | 0.0917889 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0879131 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0806872 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0781958 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0723813 |
| PGK1 | phosphoglycerate kinase 1 | 0.0715868 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0692379 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0686371 |
| HLA-A | major histocompatibility complex, class I, A | 0.0684677 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0675783 |
| HLA-B | major histocompatibility complex, class I, B | 0.066025 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0658141 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0638571 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0637581 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0616763 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0605965 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0588597 |
| FAM13A | family with sequence similarity 13, member A | 0.0579816 |
| SPAG9 | sperm associated antigen 9 | 0.0567861 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0560038 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0557742 |
| DNER | delta/notch-like EGF repeat containing | 0.0547328 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0533484 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0511533 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0502383 |
| MCL1 | myeloid cell leukemia 1 | 0.0495853 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0489648 |
| CTBP2 | C-terminal binding protein 2 | 0.0465112 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0457384 |
| ANKRD11 | ankyrin repeat domain 11 | 0.045157 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0447333 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0443898 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0440184 |
| ACTG1 | actin gamma 1 | 0.0433075 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0431194 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0430021 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0418608 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0414638 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0411086 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.040981 |
| TBXT | T-box transcription factor T | 0.0409186 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0408415 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0403434 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0397992 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0397091 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0394164 |
| COPA | coatomer protein complex, subunit alpha | 0.0391835 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0389627 |
| TPM3 | tropomyosin 3 | 0.0382143 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0381373 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0379905 |
| FLNB | filamin B, beta | 0.037212 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0365545 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.036321 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0361675 |
| B2M | beta-2-microglobulin | 0.035504 |
| HELZ | helicase with zinc finger | 0.0354181 |
| NUP58 | nucleoporin 58 | 0.0351416 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0347641 |
| PTEN | phosphatase and tensin homolog | 0.0347607 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0343667 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0341615 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0340024 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0339685 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0337481 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0337408 |
| SETD5 | SET domain containing 5 | 0.0332034 |
| RUNX1 | runt-related transcription factor 1 | 0.0326899 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0322173 |
| RNF145 | ring finger protein 145 | 0.032076 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0317128 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0314551 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0312412 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0310918 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0309947 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0308432 |
| PCBP2 | poly(rC) binding protein 2 | 0.0305289 |
| FLNA | filamin A, alpha | 0.0305046 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0304644 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0304325 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0304275 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0302246 |
| LAMA5 | laminin, alpha 5 | 0.0301026 |
| EFNA5 | ephrin-A5 | 0.0296409 |
| EZR | ezrin | 0.0295776 |
| MEF2D | myocyte enhancer factor 2D | 0.0293303 |
| ZNF292 | zinc finger protein 292 | 0.0292379 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0291251 |
| ZNF638 | zinc finger protein 638 | 0.0290693 |
| NGLY1 | N-glycanase 1 | 0.0289839 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0289449 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0286547 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0285434 |
| GOLGA4 | golgin A4 | 0.0285033 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0283085 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0282702 |
| ATF3 | activating transcription factor 3 | 0.02811 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0280981 |
| RPL13A | ribosomal protein L13a | 0.0279005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.164225 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.158551 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.146851 |
| ASPH | aspartate beta-hydroxylase | -0.144077 |
| GDA | guanine deaminase | -0.140378 |
| TXNRD1 | thioredoxin reductase 1 | -0.128925 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.103674 |
| COL5A2 | collagen, type V, alpha 2 | -0.0883275 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0781886 |
| KYNU | kynureninase | -0.070401 |
| NRCAM | neuronal cell adhesion molecule | -0.0664712 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0630388 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0628622 |
| RPLP1 | ribosomal protein, large, P1 | -0.0610872 |
| RPS2 | ribosomal protein S2 | -0.0610258 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.060885 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0605253 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0577901 |
| RPS24 | ribosomal protein S24 | -0.057072 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0563478 |
| GRAMD1B | GRAM domain containing 1B | -0.0553286 |
| NEK7 | NIMA-related kinase 7 | -0.0535168 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0487171 |
| FTL | ferritin, light polypeptide | -0.04575 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0434003 |
| TNPO1 | transportin 1 | -0.0421769 |
| SMYD3 | SET and MYND domain containing 3 | -0.0414453 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0400224 |
| PDE10A | phosphodiesterase 10A | -0.0398178 |
| CTSC | cathepsin C | -0.0385124 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0380402 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.036162 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0354401 |
| VIM | vimentin | -0.0352386 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0349676 |
| MYOF | myoferlin | -0.0345526 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0341989 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0339807 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0323509 |
| PTGR1 | prostaglandin reductase 1 | -0.0319417 |
| MT2A | metallothionein 2A | -0.0317065 |
| OSMR | oncostatin M receptor | -0.0315411 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0300682 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0300334 |
| IPO7 | importin 7 | -0.0293099 |
| VCL | vinculin | -0.0290562 |
| LDHA | lactate dehydrogenase A | -0.0287986 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0284642 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0272425 |
| PRDX1 | peroxiredoxin 1 | -0.0270997 |
| RPLP0 | ribosomal protein, large, P0 | -0.026696 |
| TUSC3 | tumor suppressor candidate 3 | -0.026483 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0264515 |
| CLTC | clathrin, heavy chain (Hc) | -0.0261359 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0259843 |
| RPL36A | ribosomal protein L36a | -0.0252387 |
| CENPF | centromere protein F, 350/400kDa | -0.0252323 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0250407 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0248518 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0245173 |
| RPL12 | ribosomal protein L12 | -0.0241143 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0237663 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0233534 |
| RPL26 | ribosomal protein L26 | -0.0231562 |
| RGS2 | regulator of G-protein signaling 2 | -0.0229403 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0226568 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0226173 |
| SRGN | serglycin | -0.0223169 |
| RAB10 | RAB10, member RAS oncogene family | -0.0221351 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0218403 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0217253 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0216745 |
| RPL7 | ribosomal protein L7 | -0.0215138 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0214439 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0212712 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0212267 |
| MKI67 | marker of proliferation Ki-67 | -0.0211425 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0209515 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0208885 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0206982 |
| CUL4B | cullin 4B | -0.0206854 |
| CADM2 | cell adhesion molecule 2 | -0.020601 |
| RPL38 | ribosomal protein L38 | -0.0205918 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0203519 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0200112 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0198209 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0198161 |
| RPL6 | ribosomal protein L6 | -0.0197472 |
| PLCB4 | phospholipase C, beta 4 | -0.0195709 |
| NTN4 | netrin 4 | -0.0195587 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0195025 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0193887 |
| PCBP3 | poly(rC) binding protein 3 | -0.0193439 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0191487 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0190915 |
| ENAH | enabled homolog (Drosophila) | -0.0188961 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0187727 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0187138 |
| RPL31 | ribosomal protein L31 | -0.0186559 |
| EXT1 | exostosin glycosyltransferase 1 | -0.018382 |
