| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.126771 |
| PGK1 | phosphoglycerate kinase 1 | 0.126247 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.121099 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.11877 |
| ZNF292 | zinc finger protein 292 | 0.117313 |
| FNDC3B | fibronectin type III domain containing 3B | 0.101665 |
| GOLGA4 | golgin A4 | 0.100751 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0979419 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0923551 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0900347 |
| NBAS | neuroblastoma amplified sequence | 0.0899179 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0831271 |
| TMSB10 | thymosin beta 10 | 0.0824458 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0772538 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0741807 |
| RUNX1 | runt-related transcription factor 1 | 0.0731851 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0720072 |
| SETD5 | SET domain containing 5 | 0.0692801 |
| BRD4 | bromodomain containing 4 | 0.0692083 |
| ANKRD11 | ankyrin repeat domain 11 | 0.068966 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0675863 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0662579 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0642539 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0639389 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0618537 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0606257 |
| RPL31 | ribosomal protein L31 | 0.0595299 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.059272 |
| NF1 | neurofibromin 1 | 0.0586056 |
| HELZ | helicase with zinc finger | 0.0576513 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0567462 |
| COG5 | component of oligomeric golgi complex 5 | 0.0555207 |
| DTNA | dystrobrevin, alpha | 0.0552729 |
| LMO7 | LIM domain 7 | 0.0552618 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.054076 |
| NDRG1 | N-myc downstream regulated 1 | 0.0538104 |
| SRPK2 | SRSF protein kinase 2 | 0.0536755 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0533595 |
| NUP58 | nucleoporin 58 | 0.053173 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.052902 |
| LDHA | lactate dehydrogenase A | 0.0507852 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0502294 |
| MED13L | mediator complex subunit 13-like | 0.0498068 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0491391 |
| OLA1 | Obg-like ATPase 1 | 0.0488743 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0485682 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0483274 |
| CCNY | cyclin Y | 0.0477733 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0470121 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.046946 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0456729 |
| GPC6 | glypican 6 | 0.0450467 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0435178 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0428524 |
| EFNA5 | ephrin-A5 | 0.0415338 |
| ZNF638 | zinc finger protein 638 | 0.0409785 |
| CERS6 | ceramide synthase 6 | 0.0408388 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0399191 |
| ACTG1 | actin gamma 1 | 0.0397299 |
| COPA | coatomer protein complex, subunit alpha | 0.038616 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0383077 |
| EZR | ezrin | 0.0373174 |
| TBC1D22A | TBC1 domain family, member 22A | 0.037205 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.036773 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0363851 |
| FTL | ferritin, light polypeptide | 0.0357336 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0355945 |
| DENND5B | DENN/MADD domain containing 5B | 0.0349301 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0338384 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0335291 |
| PARD3 | par-3 family cell polarity regulator | 0.0330819 |
| NBEAL1 | neurobeachin-like 1 | 0.0324754 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0321628 |
| MED13 | mediator complex subunit 13 | 0.0320953 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0316834 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0315665 |
| PHIP | pleckstrin homology domain interacting protein | 0.0306249 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.030593 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0305358 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0298181 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0296725 |
| OGA | O-GlcNAcase | 0.0286425 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0276712 |
| RBM39 | RNA binding motif protein 39 | 0.0274615 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0272205 |
| GRB10 | growth factor receptor-bound protein 10 | 0.026226 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0261675 |
| RPS6 | ribosomal protein S6 | 0.0250813 |
| RPS27A | ribosomal protein S27a | 0.0248377 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0248054 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0241549 |
| RAB10 | RAB10, member RAS oncogene family | 0.0237603 |
| TLK1 | tousled-like kinase 1 | 0.0235778 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0234119 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0228661 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0224903 |
| PRKCA | protein kinase C, alpha | 0.0224834 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0222571 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0221598 |
| FMN1 | formin 1 | 0.0220762 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.16552 |
| LAMA4 | laminin, alpha 4 | -0.158682 |
| VIM | vimentin | -0.157195 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.153814 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.136644 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125765 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.120687 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.116196 |
| SLTM | SAFB-like, transcription modulator | -0.115069 |
| RSF1 | remodeling and spacing factor 1 | -0.0997776 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0962044 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0960671 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0903614 |
| GPHN | gephyrin | -0.0902688 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0893033 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0845485 |
| TXNRD1 | thioredoxin reductase 1 | -0.0824821 |
| MT2A | metallothionein 2A | -0.0804967 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0754493 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0752641 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0746182 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0744248 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0743658 |
| GOLGB1 | golgin B1 | -0.074133 |
| SLC38A1 | solute carrier family 38, member 1 | -0.073881 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0737005 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0736227 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0727459 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0691789 |
| PTK2 | protein tyrosine kinase 2 | -0.0679622 |
| ITGA6 | integrin, alpha 6 | -0.0668517 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0640139 |
| CDH13 | cadherin 13 | -0.0618733 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0616988 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0613346 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0587776 |
| STC1 | stanniocalcin 1 | -0.0553897 |
| EGFR | epidermal growth factor receptor | -0.0534871 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0534356 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0532865 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0524972 |
| AOPEP | aminopeptidase O (putative) | -0.0523354 |
| FNIP1 | folliculin interacting protein 1 | -0.0521003 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0517664 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0513846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0512759 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0509303 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0504388 |
| ADIPOR2 | adiponectin receptor 2 | -0.0502372 |
| CCNI | cyclin I | -0.0498381 |
| FAM13A | family with sequence similarity 13, member A | -0.0492049 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0477924 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0474201 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0459622 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0450544 |
| NAV2 | neuron navigator 2 | -0.0412027 |
| SMYD3 | SET and MYND domain containing 3 | -0.041019 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.04099 |
| CMIP | c-Maf inducing protein | -0.0404938 |
| SPAG9 | sperm associated antigen 9 | -0.0404703 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0394751 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.038999 |
| RIGI | RNA sensor RIG-I | -0.0381592 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0368107 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0363954 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0361819 |
| ANXA2 | annexin A2 | -0.0355137 |
| PTMA | prothymosin, alpha | -0.0354776 |
| PRKD3 | protein kinase D3 | -0.0353346 |
| ATXN1 | ataxin 1 | -0.0349617 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0346859 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0343024 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0341747 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.033315 |
| CTBP2 | C-terminal binding protein 2 | -0.0326612 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0324306 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.0319305 |
| SSH2 | slingshot protein phosphatase 2 | -0.0306939 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0306106 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0289985 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0277744 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0275301 |
| PRELID2 | PRELI domain containing 2 | -0.0274167 |
| JMJD1C | jumonji domain containing 1C | -0.0273766 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0272724 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0272463 |
| LSAMP | limbic system-associated membrane protein | -0.0272102 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0269084 |
| SEPTIN2 | septin 2 | -0.026215 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0256663 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0254633 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0254616 |
| TPI1 | triosephosphate isomerase 1 | -0.0248009 |
| APP | amyloid beta (A4) precursor protein | -0.0242987 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0238123 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.023595 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.023529 |
| ACTN4 | actinin, alpha 4 | -0.0226702 |
| CUL4A | cullin 4A | -0.0221658 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0219937 |
