| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.114536 |
| NTM | neurotrimin | 0.104928 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0864248 |
| TMSB4X | thymosin beta 4, X-linked | 0.0795931 |
| H1-4 | H1.4 linker histone, cluster member | 0.0758679 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0638658 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0624673 |
| NFIA | nuclear factor I/A | 0.0623437 |
| RPS12 | ribosomal protein S12 | 0.0603901 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0599889 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.058958 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0547565 |
| THBS1 | thrombospondin 1 | 0.0547364 |
| TOX | thymocyte selection-associated high mobility group box | 0.0535387 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0517605 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.050498 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0494991 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0483657 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0479346 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0477151 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0474044 |
| FIGN | fidgetin | 0.0473996 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0472801 |
| ACTN4 | actinin, alpha 4 | 0.0472635 |
| POU3F2 | POU class 3 homeobox 2 | 0.0455309 |
| RPL4 | ribosomal protein L4 | 0.0448522 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0444863 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0440771 |
| MKI67 | marker of proliferation Ki-67 | 0.0435188 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0432434 |
| XPO1 | exportin 1 | 0.0424707 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0421635 |
| ANXA5 | annexin A5 | 0.0418875 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0417669 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0416019 |
| MYO10 | myosin X | 0.0410379 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0408125 |
| PHF21A | PHD finger protein 21A | 0.0399634 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0398635 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0395339 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0392336 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0385122 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0378914 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0373807 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0370543 |
| OGA | O-GlcNAcase | 0.0368104 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0362584 |
| FUS | FUS RNA binding protein | 0.0360741 |
| H1-2 | H1.2 linker histone, cluster member | 0.0360038 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0355441 |
| MEF2C | myocyte enhancer factor 2C | 0.0348427 |
| LRRC4C | leucine rich repeat containing 4C | 0.0347323 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.034549 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0345093 |
| THOC2 | THO complex 2 | 0.0342251 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0341711 |
| RBM20 | RNA binding motif protein 20 | 0.0341683 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0339128 |
| NONO | non-POU domain containing, octamer-binding | 0.0338416 |
| RPL11 | ribosomal protein L11 | 0.03373 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0335258 |
| PCDH7 | protocadherin 7 | 0.0332994 |
| ANXA1 | annexin A1 | 0.0330863 |
| RPL37 | ribosomal protein L37 | 0.0330848 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0324239 |
| PDGFC | platelet derived growth factor C | 0.0321768 |
| TPM3 | tropomyosin 3 | 0.032054 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0320137 |
| CALR | calreticulin | 0.0318046 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0316696 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0314325 |
| EXT1 | exostosin glycosyltransferase 1 | 0.031406 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0311693 |
| FOXP2 | forkhead box P2 | 0.0308464 |
| ZFR | zinc finger RNA binding protein | 0.0308437 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0305591 |
| WDR70 | WD repeat domain 70 | 0.030141 |
| CCN2 | cellular communication network factor 2 | 0.0300721 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0299177 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0295213 |
| UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 | 0.0294836 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0291961 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0291777 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0288394 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.028802 |
| RPL3 | ribosomal protein L3 | 0.0286693 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0281437 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0280335 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0279989 |
| BNC2 | basonuclin 2 | 0.0279872 |
| RPS3 | ribosomal protein S3 | 0.0277436 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | 0.0271836 |
| RPL26 | ribosomal protein L26 | 0.0268486 |
| POFUT1 | protein O-fucosyltransferase 1 | 0.026651 |
| ADAR | adenosine deaminase, RNA-specific | 0.0266426 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0266029 |
| SATB2 | SATB homeobox 2 | 0.0263795 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0263505 |
| ZNF516 | zinc finger protein 516 | 0.02607 |
| RPLP2 | ribosomal protein, large, P2 | 0.0260079 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128333 |
| SPAG9 | sperm associated antigen 9 | -0.0967265 |
| PHIP | pleckstrin homology domain interacting protein | -0.0947613 |
| VIM | vimentin | -0.0891269 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0878897 |
| MAP4 | microtubule-associated protein 4 | -0.0856566 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0769001 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0688166 |
| FBXO11 | F-box protein 11 | -0.0649132 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0642333 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0620919 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0603966 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0593545 |
| SYT1 | synaptotagmin I | -0.0532058 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0525791 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0516478 |
| HDAC9 | histone deacetylase 9 | -0.0515973 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0513669 |
| TMSB10 | thymosin beta 10 | -0.0512024 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0511805 |
| RYBP | RING1 and YY1 binding protein | -0.0502382 |
| LATS2 | large tumor suppressor kinase 2 | -0.0497077 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0491661 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0478594 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0476239 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0468237 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0460647 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0445087 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0442944 |
| B2M | beta-2-microglobulin | -0.0436748 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0406386 |
| GPC3 | glypican 3 | -0.0404281 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0397957 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0394656 |
| GNAS | GNAS complex locus | -0.0391392 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0386091 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0385102 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.037962 |
| SRP54 | signal recognition particle 54kDa | -0.0367537 |
| CADM2 | cell adhesion molecule 2 | -0.0360548 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0359005 |
| PLPP1 | phospholipid phosphatase 1 | -0.0354368 |
| FN1 | fibronectin 1 | -0.0352262 |
| LDHA | lactate dehydrogenase A | -0.0347013 |
| WWC2 | WW and C2 domain containing 2 | -0.034563 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0338193 |
| RFPL4B | ret finger protein-like 4B | -0.0337053 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.033478 |
| HMGA2 | high mobility group AT-hook 2 | -0.0333825 |
| HMGB1 | high mobility group box 1 | -0.0332007 |
| COL1A2 | collagen, type I, alpha 2 | -0.0329378 |
| TMEM123 | transmembrane protein 123 | -0.0321417 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0320533 |
| ANLN | anillin, actin binding protein | -0.0319502 |
| RPL35A | ribosomal protein L35a | -0.0318575 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0316951 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0315814 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0314751 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0313982 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.031136 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0310933 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0307937 |
| LYST | lysosomal trafficking regulator | -0.0306495 |
| ZNF385D | zinc finger protein 385D | -0.030299 |
| CDC73 | cell division cycle 73 | -0.0302757 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0302517 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0301594 |
| COG5 | component of oligomeric golgi complex 5 | -0.0298305 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.0297763 |
| TSPAN12 | tetraspanin 12 | -0.0296623 |
| RAB10 | RAB10, member RAS oncogene family | -0.0295385 |
| NRG1 | neuregulin 1 | -0.029278 |
| AHI1 | Abelson helper integration site 1 | -0.029134 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0290849 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0288758 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0288665 |
| POTEF | POTE ankyrin domain family, member F | -0.0285224 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0282737 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.028268 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0281188 |
| FGF13 | fibroblast growth factor 13 | -0.0281022 |
| UBXN7 | UBX domain protein 7 | -0.0280209 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0278823 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0277903 |
| MLEC | malectin | -0.0275747 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0275405 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0274883 |
| NOP58 | NOP58 ribonucleoprotein | -0.0274669 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0274534 |
| PRR16 | proline rich 16 | -0.027442 |
| RNF13 | ring finger protein 13 | -0.02739 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0272858 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.027168 |
| PAPOLA | poly(A) polymerase alpha | -0.0270921 |
| PFN1 | profilin 1 | -0.0270748 |
| FAM168A | family with sequence similarity 168, member A | -0.0270516 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | -0.0270438 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0270317 |
| AK1 | adenylate kinase 1 | -0.026888 |
| FST | follistatin | -0.0265553 |
