Irinotecan (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.188514
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.157934
RPS16 ribosomal protein S16 0.143146
SMAD3 SMAD family member 3 0.131231
TRIO trio Rho guanine nucleotide exchange factor 0.131083
SDK1 sidekick cell adhesion molecule 1 0.12146
SEPTIN9 septin 9 0.114803
SBF2 SET binding factor 2 0.0908772
SRRM2 serine/arginine repetitive matrix 2 0.0790888
ZCCHC7 zinc finger, CCHC domain containing 7 0.0750213
ATXN1 ataxin 1 0.0710751
ZNF292 zinc finger protein 292 0.0699069
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0693093
CDK19 cyclin-dependent kinase 19 0.0688784
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0686183
MYH9 myosin, heavy chain 9, non-muscle 0.0676335
ACTG1 actin gamma 1 0.066919
ANKRD11 ankyrin repeat domain 11 0.0661962
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0646026
PTMA prothymosin, alpha 0.0644173
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0641293
TNS3 tensin 3 0.0590753
FBL fibrillarin 0.057847
MED13L mediator complex subunit 13-like 0.0577798
OGA O-GlcNAcase 0.0561625
PGK1 phosphoglycerate kinase 1 0.0543073
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0537497
PRELID2 PRELI domain containing 2 0.0536906
SFTPA2 surfactant protein A2 0.0520754
FMNL2 formin-like 2 0.051882
UTRN utrophin 0.0511797
PTK2 protein tyrosine kinase 2 0.0511528
NFIA nuclear factor I/A 0.0490475
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0488366
FLNB filamin B, beta 0.0478605
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0476165
IGF1R insulin-like growth factor 1 receptor 0.047541
SLC35F3 solute carrier family 35, member F3 0.0466604
PLEC plectin 0.0464401
CTBP2 C-terminal binding protein 2 0.0457946
TRERF1 transcriptional regulating factor 1 0.045375
AKAP13 A kinase (PRKA) anchor protein 13 0.0452002
HPCAL1 hippocalcin-like 1 0.0450101
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0445167
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0439997
RPS3 ribosomal protein S3 0.0438902
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.043823
RPL11 ribosomal protein L11 0.0436916
NCOR2 nuclear receptor corepressor 2 0.0428439
COL18A1 collagen, type XVIII, alpha 1 0.0422445
AFAP1 actin filament associated protein 1 0.0421364
PCBP2 poly(rC) binding protein 2 0.0420262
ADM adrenomedullin 0.0415629
ARID1B AT rich interactive domain 1B (SWI1-like) 0.041298
GSE1 Gse1 coiled-coil protein 0.0412555
PDE10A phosphodiesterase 10A 0.0412125
SMYD3 SET and MYND domain containing 3 0.0407738
ESYT2 extended synaptotagmin-like protein 2 0.0406944
DST dystonin 0.0394712
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0393728
RPS12 ribosomal protein S12 0.0388954
MATR3 matrin 3 0.0387254
AFDN afadin, adherens junction formation factor 0.0387191
MBNL2 muscleblind-like splicing regulator 2 0.0386935
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0383316
NAV2 neuron navigator 2 0.0379099
ZFAND3 zinc finger, AN1-type domain 3 0.0377832
BIRC6 baculoviral IAP repeat containing 6 0.0373092
RAD51B RAD51 paralog B 0.0370467
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0369213
TBC1D5 TBC1 domain family, member 5 0.0368357
XPO1 exportin 1 0.0354223
EIF4B eukaryotic translation initiation factor 4B 0.0352641
LPP LIM domain containing preferred translocation partner in lipoma 0.0350492
TPD52 tumor protein D52 0.0348044
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0339801
ARHGAP26 Rho GTPase activating protein 26 0.0339477
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0335991
YEATS2 YEATS domain containing 2 0.0334596
NACA nascent polypeptide-associated complex alpha subunit 0.0326079
GARS1 glycyl-tRNA synthetase 1 0.0323499
STEAP3 STEAP family member 3, metalloreductase 0.031913
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0315383
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0314437
ZNF780B zinc finger protein 780B 0.031405
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0312756
TNRC6A trinucleotide repeat containing 6A 0.0309958
PHF21A PHD finger protein 21A 0.0309841
SAMD4B sterile alpha motif domain containing 4B 0.0307298
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0306186
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0303776
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0297856
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0297563
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0297535
ZNF638 zinc finger protein 638 0.0295968
ZMIZ1 zinc finger, MIZ-type containing 1 0.029476
VEGFA vascular endothelial growth factor A 0.0294624
ZNF148 zinc finger protein 148 0.0294521
FOXJ3 forkhead box J3 0.0291179
HSPG2 heparan sulfate proteoglycan 2 0.0289663

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.248882
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.138536
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.135123
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128823
CD44 CD44 molecule (Indian blood group) -0.10737
TM4SF1 transmembrane 4 L six family member 1 -0.0853812
AKAP12 A kinase (PRKA) anchor protein 12 -0.0793601
MT2A metallothionein 2A -0.073649
VIM vimentin -0.0713226
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0663567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0630102
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0618543
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0550149
WWTR1 WW domain containing transcription regulator 1 -0.0545981
FOSL1 FOS-like antigen 1 -0.0545395
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0527091
OSMR oncostatin M receptor -0.0520367
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0480577
ELL2 elongation factor, RNA polymerase II, 2 -0.0475836
BMAL2 basic helix-loop-helix ARNT like 2 -0.0459286
RAP1B RAP1B, member of RAS oncogene family -0.045601
TMSB10 thymosin beta 10 -0.0446767
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0435616
NCEH1 neutral cholesterol ester hydrolase 1 -0.0427346
NT5E 5'-nucleotidase, ecto (CD73) -0.0422246
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0419816
EGR1 early growth response 1 -0.0412725
VMP1 vacuole membrane protein 1 -0.0408673
BIRC3 baculoviral IAP repeat containing 3 -0.0395188
CANX calnexin -0.0394553
RTN4 reticulon 4 -0.0375943
MCL1 myeloid cell leukemia 1 -0.0368453
ANGPTL4 angiopoietin-like 4 -0.0353079
CDCP1 CUB domain containing protein 1 -0.0351996
IPO7 importin 7 -0.03471
SLC38A2 solute carrier family 38, member 2 -0.0346586
ICAM1 intercellular adhesion molecule 1 -0.0342848
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0340892
MORF4L2 mortality factor 4 like 2 -0.0332409
IL6ST interleukin 6 signal transducer -0.0331822
KLF6 Kruppel-like factor 6 -0.0328592
FAM3C family with sequence similarity 3, member C -0.0305545
ITGB5 integrin, beta 5 -0.0305229
IER3 immediate early response 3 -0.0303951
FHL2 four and a half LIM domains 2 -0.030099
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0298964
FBXO11 F-box protein 11 -0.0297268
NPC1 Niemann-Pick disease, type C1 -0.0296998
RAB7A RAB7A, member RAS oncogene family -0.0296735
ITGAV integrin, alpha V -0.0287197
NABP1 nucleic acid binding protein 1 -0.0283666
MYO1E myosin IE -0.0280007
FTL ferritin, light polypeptide -0.0277506
EPAS1 endothelial PAS domain protein 1 -0.0271602
FTH1 ferritin, heavy polypeptide 1 -0.0264337
LOC102724023 ES1 protein homolog, mitochondrial -0.0256551
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0246059
STK17A serine/threonine kinase 17a -0.0239647
ARHGAP29 Rho GTPase activating protein 29 -0.0231536
RPLP1 ribosomal protein, large, P1 -0.0230006
SQSTM1 sequestosome 1 -0.0228618
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0227995
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0227287
MAP1B microtubule-associated protein 1B -0.0221592
C15ORF48 chromosome 15 open reading frame 48 -0.021882
SETX senataxin -0.0217893
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.0214601
CCND1 cyclin D1 -0.021261
DNMBP dynamin binding protein -0.0211761
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0211545
INTS6 integrator complex subunit 6 -0.0210062
TPM1 tropomyosin 1 (alpha) -0.0209454
MOSMO modulator of smoothened -0.0209109
VDAC1 voltage-dependent anion channel 1 -0.0208118
CAV1 caveolin 1, caveolae protein, 22kDa -0.0207942
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.020769
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0207288
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.020684
BIRC2 baculoviral IAP repeat containing 2 -0.020628
SPRY4 sprouty homolog 4 (Drosophila) -0.0204403
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0204089
CSNK1A1 casein kinase 1, alpha 1 -0.0203312
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0202292
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0201751
MAGT1 magnesium transporter 1 -0.0199315
MED29 mediator complex subunit 29 -0.0198931
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0198157
IFITM3 interferon induced transmembrane protein 3 -0.0197587
IL13RA1 interleukin 13 receptor, alpha 1 -0.0194941
S100A10 S100 calcium binding protein A10 -0.0191539
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0187567
NUP98 nucleoporin 98kDa -0.0186438
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0186048
MSRB3 methionine sulfoxide reductase B3 -0.0183644
FRMD6 FERM domain containing 6 -0.0182722
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0180631
TMEM41B transmembrane protein 41B -0.0179068
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0177891
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0177498
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0176781