| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.0920914 |
| HLA-B | major histocompatibility complex, class I, B | 0.0800535 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0776918 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0771561 |
| KRT17 | keratin 17, type I | 0.0757574 |
| LAMB3 | laminin, beta 3 | 0.0676833 |
| MUC4 | mucin 4, cell surface associated | 0.0655471 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0646195 |
| MYO6 | myosin VI | 0.0644337 |
| VEGFA | vascular endothelial growth factor A | 0.0610909 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0603881 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0581942 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0573795 |
| KRT7 | keratin 7, type II | 0.0573144 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0573004 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0571401 |
| PLEC | plectin | 0.054857 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0538545 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0533532 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0533113 |
| ARRDC3 | arrestin domain containing 3 | 0.0531899 |
| SNX9 | sorting nexin 9 | 0.0514689 |
| RPS12 | ribosomal protein S12 | 0.0495098 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0490702 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0485905 |
| KRT8 | keratin 8, type II | 0.0484238 |
| OGA | O-GlcNAcase | 0.0474773 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0467872 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0465975 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0461243 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0461073 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0453913 |
| RUNX1 | runt-related transcription factor 1 | 0.0441798 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0429125 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.042641 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0417872 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0410813 |
| CTBP2 | C-terminal binding protein 2 | 0.0406427 |
| LIPH | lipase, member H | 0.0406268 |
| TMEM51 | transmembrane protein 51 | 0.0402298 |
| ZNF148 | zinc finger protein 148 | 0.0399643 |
| TJP2 | tight junction protein 2 | 0.0396915 |
| BRD4 | bromodomain containing 4 | 0.0388934 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0387219 |
| SVIL | supervillin | 0.0385761 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0382177 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0378273 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0376788 |
| AFDN | afadin, adherens junction formation factor | 0.0374839 |
| RPS3 | ribosomal protein S3 | 0.0373259 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0366845 |
| FMNL2 | formin-like 2 | 0.0363909 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0363704 |
| HLA-A | major histocompatibility complex, class I, A | 0.0359099 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0357838 |
| ZNF292 | zinc finger protein 292 | 0.0356039 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0353942 |
| RPL5 | ribosomal protein L5 | 0.0351689 |
| ANXA11 | annexin A11 | 0.0350537 |
| XPO1 | exportin 1 | 0.0350201 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0349317 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0349189 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0347435 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0347362 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0345768 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0344616 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0344015 |
| FNIP1 | folliculin interacting protein 1 | 0.0343685 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0340794 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.034041 |
| JAK1 | Janus kinase 1 | 0.033909 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0338863 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0337275 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0335605 |
| MATR3 | matrin 3 | 0.0335389 |
| RPL13A | ribosomal protein L13a | 0.033483 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0332984 |
| RPS8 | ribosomal protein S8 | 0.0329033 |
| HDGF | hepatoma-derived growth factor | 0.0327071 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0326589 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0326114 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0324248 |
| GOLGA4 | golgin A4 | 0.0321795 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0321207 |
| FNBP4 | formin binding protein 4 | 0.0320466 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0320202 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0318099 |
| YEATS2 | YEATS domain containing 2 | 0.0317046 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0310355 |
| RPS6 | ribosomal protein S6 | 0.030871 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0306935 |
| MYO5B | myosin VB | 0.030618 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0303567 |
| RPL37A | ribosomal protein L37a | 0.0303548 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0302566 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0302182 |
| LOC112694756 | uncharaterized LOC112694756 | 0.030216 |
| ETNK1 | ethanolamine kinase 1 | 0.0301619 |
| KRT18 | keratin 18, type I | 0.0301038 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0300561 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.264022 |
| LAMA4 | laminin, alpha 4 | -0.114619 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.111342 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101309 |
| ASPH | aspartate beta-hydroxylase | -0.089373 |
| TMSB10 | thymosin beta 10 | -0.0869161 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0864088 |
| CANX | calnexin | -0.0842626 |
| ANXA2 | annexin A2 | -0.0741645 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0629127 |
| MT2A | metallothionein 2A | -0.0618775 |
| INTS6 | integrator complex subunit 6 | -0.0617396 |
| FN1 | fibronectin 1 | -0.0615836 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0595637 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0581221 |
| EGR1 | early growth response 1 | -0.0570422 |
| CD44 | CD44 molecule (Indian blood group) | -0.0556024 |
| VCL | vinculin | -0.0534963 |
| KRT19 | keratin 19, type I | -0.0520688 |
| LMO7 | LIM domain 7 | -0.0511207 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0492869 |
| SP100 | SP100 nuclear antigen | -0.0460652 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0455049 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0443683 |
| HMGA1 | high mobility group AT-hook 1 | -0.0437153 |
| FTL | ferritin, light polypeptide | -0.0435318 |
| RASAL2 | RAS protein activator like 2 | -0.0429083 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0424422 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0422461 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.040863 |
| AHNAK | AHNAK nucleoprotein | -0.0406571 |
| PTMA | prothymosin, alpha | -0.0404258 |
| WWC1 | WW and C2 domain containing 1 | -0.039763 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0386845 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0372305 |
| LDHA | lactate dehydrogenase A | -0.0370202 |
| ENO1 | enolase 1, (alpha) | -0.0363417 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0353305 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0353134 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0344695 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0343437 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0339219 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0326742 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0321422 |
| HMGA2 | high mobility group AT-hook 2 | -0.0320031 |
| S100A6 | S100 calcium binding protein A6 | -0.0317752 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.031705 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0315898 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.031488 |
| TMEM123 | transmembrane protein 123 | -0.0312429 |
| POTEF | POTE ankyrin domain family, member F | -0.0311901 |
| MX1 | MX dynamin-like GTPase 1 | -0.0311015 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0310879 |
| IFI44 | interferon-induced protein 44 | -0.0308846 |
| SLC38A2 | solute carrier family 38, member 2 | -0.030065 |
| RIGI | RNA sensor RIG-I | -0.0298585 |
| NABP1 | nucleic acid binding protein 1 | -0.0297734 |
| CCNL1 | cyclin L1 | -0.0296727 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0296366 |
| MX2 | MX dynamin-like GTPase 2 | -0.029349 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0291138 |
| ANXA1 | annexin A1 | -0.0289387 |
| EMP1 | epithelial membrane protein 1 | -0.0288515 |
| VIM | vimentin | -0.0283995 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0283142 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0282919 |
| H1-0 | H1.0 linker histone | -0.027683 |
| ITGA6 | integrin, alpha 6 | -0.0272364 |
| OSMR | oncostatin M receptor | -0.0271889 |
| FOSL1 | FOS-like antigen 1 | -0.0271774 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.027026 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0268254 |
| FRMD5 | FERM domain containing 5 | -0.0268225 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0267095 |
| ANLN | anillin, actin binding protein | -0.0266496 |
| IFI44L | interferon-induced protein 44-like | -0.0263832 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0263095 |
| EHF | ets homologous factor | -0.0259787 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0258186 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0257122 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0255607 |
| RPL35A | ribosomal protein L35a | -0.025359 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252372 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0251327 |
| S100A11 | S100 calcium binding protein A11 | -0.0247837 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0247095 |
| EHBP1 | EH domain binding protein 1 | -0.0246285 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0245934 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0240056 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0236871 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.023294 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0232355 |
| LAMC2 | laminin, gamma 2 | -0.023115 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0231148 |
| LIMA1 | LIM domain and actin binding 1 | -0.023084 |
| MT1X | metallothionein 1X | -0.0230717 |
| MORF4L2 | mortality factor 4 like 2 | -0.0226088 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0225465 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0224268 |
| GNAS | GNAS complex locus | -0.021821 |
