| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAV2 | neuron navigator 2 | 0.100335 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0968221 |
| EXT1 | exostosin glycosyltransferase 1 | 0.093592 |
| ACTG1 | actin gamma 1 | 0.0864931 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0858321 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0842242 |
| ZNF292 | zinc finger protein 292 | 0.076713 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0762492 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0734223 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0715299 |
| PTK2 | protein tyrosine kinase 2 | 0.0705036 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0684041 |
| USP3 | ubiquitin specific peptidase 3 | 0.0658176 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0617869 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0592662 |
| SBF2 | SET binding factor 2 | 0.0583844 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.058109 |
| UPP1 | uridine phosphorylase 1 | 0.0554228 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.054999 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0531798 |
| CORO1C | coronin, actin binding protein, 1C | 0.052215 |
| ANK2 | ankyrin 2, neuronal | 0.0518556 |
| NCKAP1 | NCK-associated protein 1 | 0.0504876 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0501395 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0496529 |
| PRELID2 | PRELI domain containing 2 | 0.0496207 |
| RUNX1 | runt-related transcription factor 1 | 0.04951 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0480036 |
| RPL23 | ribosomal protein L23 | 0.0475665 |
| RAD51B | RAD51 paralog B | 0.0466519 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0462575 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0461185 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0457793 |
| ANXA5 | annexin A5 | 0.0453979 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.04529 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0444935 |
| EXOC4 | exocyst complex component 4 | 0.0433702 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0429531 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0428601 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0423731 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0422009 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0419622 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0417314 |
| AHNAK | AHNAK nucleoprotein | 0.0415749 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0412155 |
| RPS8 | ribosomal protein S8 | 0.0410657 |
| RTN4 | reticulon 4 | 0.0410207 |
| RPL4 | ribosomal protein L4 | 0.0404535 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0403091 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0400364 |
| OGA | O-GlcNAcase | 0.039928 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0378326 |
| FMNL2 | formin-like 2 | 0.0374187 |
| HELZ | helicase with zinc finger | 0.0366599 |
| PKM | pyruvate kinase, muscle | 0.0364691 |
| ASPH | aspartate beta-hydroxylase | 0.0359119 |
| RLF | rearranged L-myc fusion | 0.0357455 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0351531 |
| FOXO3 | forkhead box O3 | 0.0344594 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0343781 |
| RBM39 | RNA binding motif protein 39 | 0.0343709 |
| RBM33 | RNA binding motif protein 33 | 0.0341009 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0339573 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0337189 |
| PGK1 | phosphoglycerate kinase 1 | 0.0336907 |
| SMYD3 | SET and MYND domain containing 3 | 0.033575 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.033508 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0333991 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0329622 |
| NUP58 | nucleoporin 58 | 0.0319279 |
| RPL7 | ribosomal protein L7 | 0.0318022 |
| FLNA | filamin A, alpha | 0.0317183 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0315235 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0314849 |
| COG5 | component of oligomeric golgi complex 5 | 0.0311096 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0307308 |
| RPL3 | ribosomal protein L3 | 0.0306844 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0304194 |
| SPAG9 | sperm associated antigen 9 | 0.0300871 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0300143 |
| RPL7A | ribosomal protein L7a | 0.0299661 |
| RPL37A | ribosomal protein L37a | 0.0297831 |
| ARFGEF3 | ARFGEF family member 3 | 0.0294264 |
| TPR | translocated promoter region, nuclear basket protein | 0.0293409 |
| TPM3 | tropomyosin 3 | 0.0288642 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0284721 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0283714 |
| RPS12 | ribosomal protein S12 | 0.0283145 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0278372 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.02772 |
| FOSL1 | FOS-like antigen 1 | 0.0273678 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0273294 |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4 | 0.0273189 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0272377 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0270722 |
| YEATS2 | YEATS domain containing 2 | 0.0270564 |
| MTMR3 | myotubularin related protein 3 | 0.0269244 |
| RPL5 | ribosomal protein L5 | 0.0269112 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0268862 |
| SMTN | smoothelin | 0.0264842 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLC1 | DLC1 Rho GTPase activating protein | -0.20973 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.133101 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.114465 |
| HDAC9 | histone deacetylase 9 | -0.086217 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0855585 |
| FLNB | filamin B, beta | -0.0854961 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0753881 |
| NAV3 | neuron navigator 3 | -0.07237 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0711593 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.06646 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0636506 |
| CALD1 | caldesmon 1 | -0.0629313 |
| PCNX4 | pecanex 4 | -0.0622483 |
| ZNF438 | zinc finger protein 438 | -0.0621123 |
| NABP1 | nucleic acid binding protein 1 | -0.0600117 |
| FRMD4A | FERM domain containing 4A | -0.0599433 |
| MT2A | metallothionein 2A | -0.0589821 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0582758 |
| HMGA2 | high mobility group AT-hook 2 | -0.0579603 |
| TTR | transthyretin | -0.0562007 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0552053 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0550612 |
| INTS6 | integrator complex subunit 6 | -0.0545307 |
| BNC2 | basonuclin 2 | -0.0532356 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0512587 |
| SP100 | SP100 nuclear antigen | -0.0491154 |
| TPM4 | tropomyosin 4 | -0.0489095 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0480296 |
| EFNB2 | ephrin-B2 | -0.0465174 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0460798 |
| TMSB10 | thymosin beta 10 | -0.0451656 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0449584 |
| FTL | ferritin, light polypeptide | -0.0444435 |
| STC1 | stanniocalcin 1 | -0.0436515 |
| RAB3IP | RAB3A interacting protein | -0.0390139 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0386725 |
| RBM25 | RNA binding motif protein 25 | -0.0376978 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0374232 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0371551 |
| LAMB3 | laminin, beta 3 | -0.0366863 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.036264 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0343624 |
| SQLE | squalene epoxidase | -0.0341432 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0333134 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0327745 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0324715 |
| GPHN | gephyrin | -0.0319335 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0317261 |
| RIGI | RNA sensor RIG-I | -0.0315347 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0312369 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0309435 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0308192 |
| NUDCD1 | NudC domain containing 1 | -0.0307574 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0303363 |
| ERBIN | erbb2 interacting protein | -0.0300378 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0299339 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0299094 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0296931 |
| UBXN4 | UBX domain protein 4 | -0.0288855 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0286346 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0281484 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0280766 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0274617 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0269168 |
| MTDH | metadherin | -0.0268011 |
| GOLGA4 | golgin A4 | -0.0265866 |
| MORF4L2 | mortality factor 4 like 2 | -0.0265095 |
| FRMD6 | FERM domain containing 6 | -0.0262082 |
| XPC | xeroderma pigmentosum, complementation group C | -0.0261917 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0261832 |
| BCL10 | B-cell CLL/lymphoma 10 | -0.0260797 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0256116 |
| SETX | senataxin | -0.0249884 |
| MT1X | metallothionein 1X | -0.0246509 |
| CANX | calnexin | -0.0245636 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0245517 |
| HLA-A | major histocompatibility complex, class I, A | -0.0243432 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0239053 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0236898 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0236178 |
| RIC1 | RAB6A GEF complex partner 1 | -0.0233872 |
| ITSN2 | intersectin 2 | -0.0233164 |
| RPS24 | ribosomal protein S24 | -0.0231266 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0230286 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | -0.0229483 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0229471 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0227587 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0225734 |
| VDAC1 | voltage-dependent anion channel 1 | -0.022525 |
| THOC2 | THO complex 2 | -0.0224579 |
| TMEM87A | transmembrane protein 87A | -0.0224457 |
| PWWP2A | PWWP domain containing 2A | -0.0222891 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0221277 |
| CD274 | CD274 molecule | -0.0219253 |
| CNTLN | centlein, centrosomal protein | -0.0218909 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0218295 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0218121 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0215049 |
| TAOK1 | TAO kinase 1 | -0.0213233 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0213214 |
