| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.118839 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.116456 |
| PGK1 | phosphoglycerate kinase 1 | 0.109931 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0913737 |
| GOLGA4 | golgin A4 | 0.0873974 |
| HLA-B | major histocompatibility complex, class I, B | 0.0873946 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0723796 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0702894 |
| ZNF292 | zinc finger protein 292 | 0.0702738 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0634516 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0623953 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0616166 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0602849 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0586277 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0579361 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0556909 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0556778 |
| CALU | calumenin | 0.0499083 |
| FMNL2 | formin-like 2 | 0.0490752 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0485143 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0474911 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0474472 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0470055 |
| PLEC | plectin | 0.0458206 |
| NCAM1 | neural cell adhesion molecule 1 | 0.045346 |
| PTK2 | protein tyrosine kinase 2 | 0.0448457 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0442866 |
| NAV2 | neuron navigator 2 | 0.0435364 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0429856 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0428717 |
| YEATS2 | YEATS domain containing 2 | 0.0428607 |
| RPS6 | ribosomal protein S6 | 0.0417541 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0410269 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0409623 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0403836 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0402439 |
| CALD1 | caldesmon 1 | 0.0402313 |
| SETD5 | SET domain containing 5 | 0.0400043 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0381648 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0381577 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0379754 |
| B2M | beta-2-microglobulin | 0.0364914 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0363727 |
| ATP13A3 | ATPase type 13A3 | 0.0362296 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.036026 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.036005 |
| ZNF638 | zinc finger protein 638 | 0.0358723 |
| VEGFA | vascular endothelial growth factor A | 0.0357565 |
| SMYD3 | SET and MYND domain containing 3 | 0.0357258 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0355631 |
| CDK19 | cyclin-dependent kinase 19 | 0.035457 |
| NCKAP1 | NCK-associated protein 1 | 0.0354562 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0353745 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0351558 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0351176 |
| APP | amyloid beta (A4) precursor protein | 0.0336541 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0336265 |
| RPS3 | ribosomal protein S3 | 0.0332818 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.033137 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0324655 |
| CEP250 | centrosomal protein 250kDa | 0.0322687 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0320295 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0317553 |
| MMP2 | matrix metallopeptidase 2 | 0.0309938 |
| LMNA | lamin A/C | 0.0307502 |
| MATR3 | matrin 3 | 0.030695 |
| SUCO | SUN domain containing ossification factor | 0.0306462 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0304864 |
| DSTN | destrin (actin depolymerizing factor) | 0.0301002 |
| RPL4 | ribosomal protein L4 | 0.0299863 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.029897 |
| RPL37A | ribosomal protein L37a | 0.0296079 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.029592 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0295822 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0293993 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0293921 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0293897 |
| RPL13A | ribosomal protein L13a | 0.0293816 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0292816 |
| NBAS | neuroblastoma amplified sequence | 0.0290712 |
| RBM39 | RNA binding motif protein 39 | 0.0288793 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0288494 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0285274 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0284621 |
| RPS12 | ribosomal protein S12 | 0.0284596 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0283972 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0281567 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0281517 |
| FAM219A | family with sequence similarity 219, member A | 0.0281124 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0277802 |
| FLNA | filamin A, alpha | 0.0277674 |
| ACTG1 | actin gamma 1 | 0.0277371 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0277304 |
| TPM1 | tropomyosin 1 (alpha) | 0.0276717 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0275724 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0274917 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0274349 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0273734 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.027182 |
| RPL11 | ribosomal protein L11 | 0.0271107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.250673 |
| FN1 | fibronectin 1 | -0.215646 |
| STC1 | stanniocalcin 1 | -0.123104 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.110412 |
| VIM | vimentin | -0.109689 |
| NDRG1 | N-myc downstream regulated 1 | -0.0844025 |
| FTL | ferritin, light polypeptide | -0.0831675 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0733517 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0733469 |
| CD44 | CD44 molecule (Indian blood group) | -0.0655872 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0621607 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.061947 |
| MT2A | metallothionein 2A | -0.0611507 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0600915 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0565076 |
| CLIC4 | chloride intracellular channel 4 | -0.0538484 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0531986 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0485997 |
| FRMD4A | FERM domain containing 4A | -0.04821 |
| SP100 | SP100 nuclear antigen | -0.0479942 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0476697 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0455711 |
| ANGPTL4 | angiopoietin-like 4 | -0.0446008 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0440057 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0426453 |
| EGR1 | early growth response 1 | -0.0418645 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0414029 |
| NRP1 | neuropilin 1 | -0.0413261 |
| COL1A2 | collagen, type I, alpha 2 | -0.0412669 |
| MEF2A | myocyte enhancer factor 2A | -0.0395757 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0393777 |
| IFI44 | interferon-induced protein 44 | -0.0377969 |
| IER3 | immediate early response 3 | -0.0356309 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.035555 |
| LDHA | lactate dehydrogenase A | -0.0354636 |
| MX1 | MX dynamin-like GTPase 1 | -0.0336272 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0333301 |
| INHBA | inhibin, beta A | -0.0325737 |
| RYBP | RING1 and YY1 binding protein | -0.0322821 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0319464 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0307555 |
| SVIL | supervillin | -0.0299002 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0298882 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0297242 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0295619 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0292842 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0291651 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0291457 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0291142 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0284814 |
| VCL | vinculin | -0.0283736 |
| CDCP1 | CUB domain containing protein 1 | -0.0282704 |
| PLIN2 | perilipin 2 | -0.0281791 |
| IFI44L | interferon-induced protein 44-like | -0.0278057 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0276828 |
| ANXA2 | annexin A2 | -0.0273462 |
| LOX | lysyl oxidase | -0.0271845 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0270576 |
| GLIS3 | GLIS family zinc finger 3 | -0.0269988 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0264215 |
| PFN1 | profilin 1 | -0.0263462 |
| NAV1 | neuron navigator 1 | -0.0260913 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0257394 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0256196 |
| CCNL1 | cyclin L1 | -0.0255611 |
| CDH13 | cadherin 13 | -0.0255123 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0253008 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0250473 |
| FOSL1 | FOS-like antigen 1 | -0.0247327 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0245811 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0241111 |
| MORF4L2 | mortality factor 4 like 2 | -0.0240299 |
| PLSCR1 | phospholipid scramblase 1 | -0.0237551 |
| CCDC88A | coiled-coil domain containing 88A | -0.0237416 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0235614 |
| TGFB1 | transforming growth factor, beta 1 | -0.0233377 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.023133 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0229199 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0228424 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0226782 |
| PMP22 | peripheral myelin protein 22 | -0.0225457 |
| JUN | jun proto-oncogene | -0.0224729 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0224284 |
| NABP1 | nucleic acid binding protein 1 | -0.0223805 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0223708 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0219523 |
| STK17A | serine/threonine kinase 17a | -0.0218443 |
| RIGI | RNA sensor RIG-I | -0.0218342 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0215772 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0215731 |
| EHD2 | EH-domain containing 2 | -0.0215112 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0214397 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0214208 |
| HMGA2 | high mobility group AT-hook 2 | -0.0213542 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0213391 |
| MX2 | MX dynamin-like GTPase 2 | -0.0202666 |
| DIAPH2 | diaphanous-related formin 2 | -0.0200574 |
| ZNF217 | zinc finger protein 217 | -0.0199312 |
| SHISA5 | shisa family member 5 | -0.0196199 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0196117 |
