| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | 0.134986 |
| TENM1 | teneurin transmembrane protein 1 | 0.123097 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.101588 |
| PDE10A | phosphodiesterase 10A | 0.0972914 |
| NDRG1 | N-myc downstream regulated 1 | 0.0894025 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0801391 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0777792 |
| CNTNAP2 | contactin associated protein-like 2 | 0.0771599 |
| SLC35F4 | solute carrier family 35, member F4 | 0.0731632 |
| GPC6 | glypican 6 | 0.0656223 |
| ZNF292 | zinc finger protein 292 | 0.0647419 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0642148 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0637144 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0635201 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0605721 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0604567 |
| PTK2 | protein tyrosine kinase 2 | 0.0551524 |
| DTNA | dystrobrevin, alpha | 0.052893 |
| VEGFA | vascular endothelial growth factor A | 0.0512958 |
| MED13L | mediator complex subunit 13-like | 0.0511575 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0507881 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.050726 |
| SMYD3 | SET and MYND domain containing 3 | 0.0481231 |
| CHGB | chromogranin B | 0.0481048 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0469423 |
| RAD51B | RAD51 paralog B | 0.0463723 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0447796 |
| AUTS2 | autism susceptibility candidate 2 | 0.0428532 |
| TPM3 | tropomyosin 3 | 0.0426772 |
| DENND1A | DENN/MADD domain containing 1A | 0.0422724 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0414945 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0410782 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0390661 |
| CCNY | cyclin Y | 0.0388884 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0387764 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0384541 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0381302 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0379063 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0378677 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0378039 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0374059 |
| RORA | RAR-related orphan receptor A | 0.0368632 |
| TPD52 | tumor protein D52 | 0.036355 |
| XPO1 | exportin 1 | 0.0363516 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0359671 |
| FAT1 | FAT atypical cadherin 1 | 0.0349135 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0346151 |
| MACROD2 | MACRO domain containing 2 | 0.0341083 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.032908 |
| MSI2 | musashi RNA-binding protein 2 | 0.0323868 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0320313 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0318516 |
| WWOX | WW domain containing oxidoreductase | 0.0318497 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0318407 |
| NUP58 | nucleoporin 58 | 0.031626 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0310114 |
| CENPF | centromere protein F, 350/400kDa | 0.0309628 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0308588 |
| GSE1 | Gse1 coiled-coil protein | 0.0302827 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0298233 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0295551 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0295032 |
| AFF1 | AF4/FMR2 family, member 1 | 0.029216 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0288374 |
| KLHL29 | kelch-like family member 29 | 0.0288281 |
| H1-4 | H1.4 linker histone, cluster member | 0.0282115 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0281713 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0281668 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0281323 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0281097 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0279455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0277776 |
| NBAS | neuroblastoma amplified sequence | 0.027495 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0273195 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0273174 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0272639 |
| FAM13A | family with sequence similarity 13, member A | 0.0271644 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0271489 |
| NFIA | nuclear factor I/A | 0.0269561 |
| MAP1B | microtubule-associated protein 1B | 0.0268976 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0266982 |
| PNN | pinin, desmosome associated protein | 0.0266496 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0266378 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.0264586 |
| NCOR1 | nuclear receptor corepressor 1 | 0.026441 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0264083 |
| HDGF | hepatoma-derived growth factor | 0.0261664 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0261285 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0260467 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0260258 |
| PRELID2 | PRELI domain containing 2 | 0.0257993 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0257375 |
| ITGAV | integrin, alpha V | 0.0255493 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255067 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0255024 |
| FOXJ3 | forkhead box J3 | 0.0253807 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0252846 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0252529 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0252527 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0252186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.122842 |
| INHBA | inhibin, beta A | -0.102101 |
| STC1 | stanniocalcin 1 | -0.0985792 |
| CALCA | calcitonin-related polypeptide alpha | -0.0964418 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0851185 |
| PEG10 | paternally expressed 10 | -0.0769005 |
| PTMA | prothymosin, alpha | -0.0755904 |
| FTL | ferritin, light polypeptide | -0.0745285 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0720018 |
| EGR1 | early growth response 1 | -0.0658793 |
| PTCHD4 | patched domain containing 4 | -0.0642232 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0620344 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.061973 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0603142 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0593367 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0562638 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0543518 |
| CNKSR3 | CNKSR family member 3 | -0.049963 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.044273 |
| RIT2 | Ras-like without CAAX 2 | -0.0438487 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0437854 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0437698 |
| CHGA | chromogranin A | -0.0436962 |
| GPC5 | glypican 5 | -0.0418435 |
| SCG2 | secretogranin II | -0.0417945 |
| FOXC1 | forkhead box C1 | -0.0401824 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0393174 |
| NCKAP5 | NCK-associated protein 5 | -0.0392588 |
| MT2A | metallothionein 2A | -0.0387081 |
| SYT4 | synaptotagmin IV | -0.0378901 |
| RPLP1 | ribosomal protein, large, P1 | -0.0357541 |
| UBB | ubiquitin B | -0.0355468 |
| TPM4 | tropomyosin 4 | -0.0346505 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0343684 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0339524 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0325649 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0320298 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0317249 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0315917 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0308477 |
| MX2 | MX dynamin-like GTPase 2 | -0.0300689 |
| RIGI | RNA sensor RIG-I | -0.0297033 |
| KIAA0825 | KIAA0825 | -0.0294233 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0291958 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0289346 |
| SP100 | SP100 nuclear antigen | -0.0287652 |
| CANX | calnexin | -0.0283838 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0283392 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0283306 |
| TXNRD1 | thioredoxin reductase 1 | -0.0277202 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0276923 |
| KIF26B | kinesin family member 26B | -0.0273688 |
| GNAS | GNAS complex locus | -0.0272127 |
| SNTG1 | syntrophin, gamma 1 | -0.0268031 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0263462 |
| NBEA | neurobeachin | -0.0262446 |
| NCOA7 | nuclear receptor coactivator 7 | -0.02585 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0256566 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.02559 |
| RPLP0 | ribosomal protein, large, P0 | -0.0254171 |
| NAV2 | neuron navigator 2 | -0.0253234 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0252982 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0251813 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0250886 |
| RPL8 | ribosomal protein L8 | -0.0249381 |
| RNF213 | ring finger protein 213 | -0.0245917 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0244788 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0237838 |
| SRP72 | signal recognition particle 72kDa | -0.0237599 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0229554 |
| PMP22 | peripheral myelin protein 22 | -0.0228203 |
| MAP7 | microtubule-associated protein 7 | -0.0227926 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0227363 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0225608 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0224111 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.022013 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0219695 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0217838 |
| MCL1 | myeloid cell leukemia 1 | -0.0216537 |
| MMP26 | matrix metallopeptidase 26 | -0.0216431 |
| HMGB1 | high mobility group box 1 | -0.0215523 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0213205 |
| NRG1 | neuregulin 1 | -0.0211575 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | -0.0211498 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0211055 |
| ATF6 | activating transcription factor 6 | -0.0210266 |
| IER3 | immediate early response 3 | -0.0209121 |
| PLSCR1 | phospholipid scramblase 1 | -0.0208642 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0208099 |
| TUBA1B | tubulin, alpha 1b | -0.0207853 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0207476 |
| CASP8AP2 | caspase 8 associated protein 2 | -0.0207252 |
| RRBP1 | ribosome binding protein 1 | -0.0205477 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.0200558 |
| FLOT1 | flotillin 1 | -0.0199116 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0198092 |
| CHRM5 | cholinergic receptor, muscarinic 5 | -0.0197591 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0196017 |
| VMP1 | vacuole membrane protein 1 | -0.0195514 |
| TUBB | tubulin, beta class I | -0.0194318 |
