| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LSAMP | limbic system-associated membrane protein | 0.168359 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.113485 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0922137 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0921962 |
| FLNA | filamin A, alpha | 0.0908622 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0869764 |
| RPS3 | ribosomal protein S3 | 0.0860752 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0841673 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.083699 |
| PGK1 | phosphoglycerate kinase 1 | 0.0799481 |
| ACTG1 | actin gamma 1 | 0.0799396 |
| MSI2 | musashi RNA-binding protein 2 | 0.0796369 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0794608 |
| PLEC | plectin | 0.0786151 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0782107 |
| RPL23 | ribosomal protein L23 | 0.0744412 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0722404 |
| NAV2 | neuron navigator 2 | 0.0706608 |
| FMNL2 | formin-like 2 | 0.0697481 |
| OGA | O-GlcNAcase | 0.0637205 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0618139 |
| PRELID2 | PRELI domain containing 2 | 0.0614261 |
| KAZN | kazrin, periplakin interacting protein | 0.0606042 |
| RPS6 | ribosomal protein S6 | 0.0594173 |
| FLNB | filamin B, beta | 0.0588121 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0562826 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0540952 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0530111 |
| CEP250 | centrosomal protein 250kDa | 0.0530033 |
| RAD51B | RAD51 paralog B | 0.0515338 |
| SMAD3 | SMAD family member 3 | 0.0513578 |
| GOLGA4 | golgin A4 | 0.0509294 |
| TPM3 | tropomyosin 3 | 0.0504142 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0503197 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0498816 |
| SMYD3 | SET and MYND domain containing 3 | 0.0496861 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0491827 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0491347 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0490219 |
| RPL3 | ribosomal protein L3 | 0.049017 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0488533 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0488175 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0486885 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0483732 |
| YEATS2 | YEATS domain containing 2 | 0.0474195 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0466077 |
| FHIT | fragile histidine triad | 0.0465196 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0463881 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0461012 |
| PMEL | premelanosome protein | 0.0457382 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0457136 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0450392 |
| RPL35A | ribosomal protein L35a | 0.0439391 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0436833 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0425503 |
| CTTN | cortactin | 0.0425332 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0418392 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0416731 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0406362 |
| SFTPA2 | surfactant protein A2 | 0.0405281 |
| CALU | calumenin | 0.0400453 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0390926 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0390906 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0379152 |
| CTBP2 | C-terminal binding protein 2 | 0.0377535 |
| SEPTIN9 | septin 9 | 0.0376501 |
| RHOA | ras homolog family member A | 0.0372501 |
| FAM13A | family with sequence similarity 13, member A | 0.0372191 |
| EXOC4 | exocyst complex component 4 | 0.0371486 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0365687 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0365628 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0363124 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0360232 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0353947 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0352422 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0351609 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0349863 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.0349076 |
| EZR | ezrin | 0.0348517 |
| RPL13A | ribosomal protein L13a | 0.0347271 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0344943 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0343393 |
| CSNK1E | casein kinase 1, epsilon | 0.0339803 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0338407 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0335933 |
| TSPAN14 | tetraspanin 14 | 0.0333622 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0332462 |
| CABIN1 | calcineurin binding protein 1 | 0.0331361 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0331333 |
| MYO9B | myosin IXB | 0.0327749 |
| RPL4 | ribosomal protein L4 | 0.0326877 |
| HLA-A | major histocompatibility complex, class I, A | 0.0326092 |
| RPS27A | ribosomal protein S27a | 0.0324108 |
| RPS20 | ribosomal protein S20 | 0.0323892 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0323873 |
| FAM219A | family with sequence similarity 219, member A | 0.0323334 |
| SETD5 | SET domain containing 5 | 0.0323091 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0321911 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0319938 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0316267 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.143664 |
| CCND1 | cyclin D1 | -0.118094 |
| FMN1 | formin 1 | -0.0910254 |
| FN1 | fibronectin 1 | -0.0791644 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0582301 |
| NDRG1 | N-myc downstream regulated 1 | -0.0579959 |
| NRG3 | neuregulin 3 | -0.0565062 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0537803 |
| CD44 | CD44 molecule (Indian blood group) | -0.0520411 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0519826 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0504565 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0503116 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0500552 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.047514 |
| SPAG9 | sperm associated antigen 9 | -0.0465549 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0464505 |
| SP100 | SP100 nuclear antigen | -0.046269 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0451121 |
| POTEF | POTE ankyrin domain family, member F | -0.0435357 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0433587 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0426145 |
| TXNRD1 | thioredoxin reductase 1 | -0.0425038 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0409359 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0404492 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0389833 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0387776 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0381266 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0378358 |
| PLSCR1 | phospholipid scramblase 1 | -0.0378185 |
| HMGA1 | high mobility group AT-hook 1 | -0.0348723 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0345497 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0337521 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.032759 |
| HDAC9 | histone deacetylase 9 | -0.032726 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0320039 |
| OXSR1 | oxidative stress responsive 1 | -0.0316717 |
| IFI44L | interferon-induced protein 44-like | -0.0312836 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0312105 |
| EMP1 | epithelial membrane protein 1 | -0.0309646 |
| TP63 | tumor protein p63 | -0.0303541 |
| CLINT1 | clathrin interactor 1 | -0.0300892 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0293666 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0289531 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288795 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0287444 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0283465 |
| RPS2 | ribosomal protein S2 | -0.0282237 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0281759 |
| IPO7 | importin 7 | -0.0281173 |
| USP53 | ubiquitin specific peptidase 53 | -0.0279463 |
| CBX3 | chromobox homolog 3 | -0.0270927 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0270509 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0265654 |
| IL6ST | interleukin 6 signal transducer | -0.0263325 |
| ENO1 | enolase 1, (alpha) | -0.0258609 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0257884 |
| RYBP | RING1 and YY1 binding protein | -0.025736 |
| KLF6 | Kruppel-like factor 6 | -0.0256399 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0254932 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0250299 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0249527 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0249314 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.024687 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0241898 |
| IER3 | immediate early response 3 | -0.0236555 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0235443 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0224239 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0222391 |
| MORF4L2 | mortality factor 4 like 2 | -0.0220283 |
| PKM | pyruvate kinase, muscle | -0.0220014 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0219409 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0218952 |
| RIGI | RNA sensor RIG-I | -0.0218173 |
| TFG | TRK-fused gene | -0.0217973 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0217374 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0216486 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0215943 |
| ANXA2 | annexin A2 | -0.021128 |
| ZNF207 | zinc finger protein 207 | -0.021047 |
| TENM1 | teneurin transmembrane protein 1 | -0.020942 |
| TPM4 | tropomyosin 4 | -0.0209307 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | -0.0207845 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0207693 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0206583 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0204617 |
| LAMB1 | laminin, beta 1 | -0.0204493 |
| CLTC | clathrin, heavy chain (Hc) | -0.0204307 |
| VMP1 | vacuole membrane protein 1 | -0.0203644 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0202313 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0200953 |
| COMMD10 | COMM domain containing 10 | -0.0195663 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0195593 |
| RBM39 | RNA binding motif protein 39 | -0.0195017 |
| AFF4 | AF4/FMR2 family, member 4 | -0.01944 |
| H3-3B | H3.3 histone B | -0.0193536 |
| FBXO32 | F-box protein 32 | -0.019315 |
| EGR1 | early growth response 1 | -0.0192912 |
| CYTH3 | cytohesin 3 | -0.0192623 |
| SCARB2 | scavenger receptor class B, member 2 | -0.0186898 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0186685 |
