| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.102503 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0902342 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0877752 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0847044 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0824805 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0805086 |
| RPL3 | ribosomal protein L3 | 0.0793596 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0716165 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0714976 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0706412 |
| MSI2 | musashi RNA-binding protein 2 | 0.0619171 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0598485 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0584679 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0584248 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0577177 |
| EZR | ezrin | 0.0571058 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0568183 |
| ANK2 | ankyrin 2, neuronal | 0.0566554 |
| PDGFC | platelet derived growth factor C | 0.05326 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0526826 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0525013 |
| SESN2 | sestrin 2 | 0.052438 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0499821 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0485127 |
| ZNF292 | zinc finger protein 292 | 0.0483454 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0472287 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.047176 |
| PCBP2 | poly(rC) binding protein 2 | 0.046403 |
| DSCAM | Down syndrome cell adhesion molecule | 0.045837 |
| RNF145 | ring finger protein 145 | 0.0452992 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0450403 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0434784 |
| VMP1 | vacuole membrane protein 1 | 0.0426675 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0426482 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.041599 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0409985 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0400698 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0397408 |
| VEGFA | vascular endothelial growth factor A | 0.039023 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0388642 |
| MED13 | mediator complex subunit 13 | 0.0387989 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0387939 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0387177 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0387048 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0382032 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0382004 |
| MED13L | mediator complex subunit 13-like | 0.037447 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0371162 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0371062 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0369828 |
| HDGF | hepatoma-derived growth factor | 0.0368833 |
| NUP58 | nucleoporin 58 | 0.0367062 |
| ANXA1 | annexin A1 | 0.0366457 |
| WDR43 | WD repeat domain 43 | 0.036587 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0360285 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0359945 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0358918 |
| SETD5 | SET domain containing 5 | 0.0356615 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0356041 |
| NFIA | nuclear factor I/A | 0.0354601 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0350971 |
| PTEN | phosphatase and tensin homolog | 0.0348038 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.03426 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0338972 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0338846 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0335834 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0335072 |
| RBM33 | RNA binding motif protein 33 | 0.033489 |
| FAT1 | FAT atypical cadherin 1 | 0.0329858 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.03292 |
| RPS12 | ribosomal protein S12 | 0.0328658 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0320609 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0318398 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0314411 |
| APP | amyloid beta (A4) precursor protein | 0.030967 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0309634 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0306853 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0306321 |
| PLXNA1 | plexin A1 | 0.0302991 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0300667 |
| SET | SET nuclear proto-oncogene | 0.029796 |
| JMJD1C | jumonji domain containing 1C | 0.0296905 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0291735 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0291363 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0291333 |
| GATA6 | GATA binding protein 6 | 0.0289436 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0288374 |
| PNN | pinin, desmosome associated protein | 0.0287769 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0286339 |
| FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.0285666 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0285128 |
| HELZ | helicase with zinc finger | 0.0283698 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0282991 |
| PREPL | prolyl endopeptidase-like | 0.0280308 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0280056 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0279416 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0278031 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0274661 |
| RBM26 | RNA binding motif protein 26 | 0.0274374 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0274296 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.230091 |
| VCL | vinculin | -0.190105 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.187308 |
| PTMA | prothymosin, alpha | -0.12046 |
| PKM | pyruvate kinase, muscle | -0.112242 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.104726 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0993025 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0979833 |
| AHNAK | AHNAK nucleoprotein | -0.093055 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0740178 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0738742 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.06642 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.052362 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0503983 |
| BMP10 | bone morphogenetic protein 10 | -0.0498606 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0497596 |
| NBEA | neurobeachin | -0.0489952 |
| S100A6 | S100 calcium binding protein A6 | -0.0447184 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.044648 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0425519 |
| MYO5C | myosin VC | -0.0422002 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0413315 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0395863 |
| RPL35A | ribosomal protein L35a | -0.038649 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0384764 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.03807 |
| CCND1 | cyclin D1 | -0.0376289 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0375243 |
| RPLP1 | ribosomal protein, large, P1 | -0.0373571 |
| FOXP1 | forkhead box P1 | -0.0370646 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0362565 |
| GLI3 | GLI family zinc finger 3 | -0.0341262 |
| DUSP6 | dual specificity phosphatase 6 | -0.0338588 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0333602 |
| ACTG1 | actin gamma 1 | -0.0333059 |
| NAV2 | neuron navigator 2 | -0.0324995 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0323314 |
| RPS24 | ribosomal protein S24 | -0.0321558 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.031114 |
| TMSB4X | thymosin beta 4, X-linked | -0.0310384 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.031034 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0308704 |
| MKI67 | marker of proliferation Ki-67 | -0.0304609 |
| HJURP | Holliday junction recognition protein | -0.0304334 |
| TJP1 | tight junction protein 1 | -0.029164 |
| PRDX2 | peroxiredoxin 2 | -0.0289164 |
| DIAPH2 | diaphanous-related formin 2 | -0.0288851 |
| RRBP1 | ribosome binding protein 1 | -0.028563 |
| OSMR | oncostatin M receptor | -0.0275936 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0267214 |
| ENO1 | enolase 1, (alpha) | -0.0267096 |
| S100A4 | S100 calcium binding protein A4 | -0.0266553 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0265465 |
| RPS27A | ribosomal protein S27a | -0.0263382 |
| HMGB1 | high mobility group box 1 | -0.0262183 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0261444 |
| LDHA | lactate dehydrogenase A | -0.0258681 |
| CANX | calnexin | -0.0258254 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0253005 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | -0.0252622 |
| RPL34 | ribosomal protein L34 | -0.0250811 |
| BMP2K | BMP2 inducible kinase | -0.0248402 |
| FTL | ferritin, light polypeptide | -0.0248028 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0246337 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0243561 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0243321 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0242481 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0238943 |
| KLF6 | Kruppel-like factor 6 | -0.02384 |
| TOB1 | transducer of ERBB2, 1 | -0.0238256 |
| THBD | thrombomodulin | -0.0235649 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.023164 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.02309 |
| FHIT | fragile histidine triad | -0.0227297 |
| PFN1 | profilin 1 | -0.0226028 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0225745 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0225741 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0223933 |
| S100A10 | S100 calcium binding protein A10 | -0.0220055 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0216569 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.021537 |
| SP100 | SP100 nuclear antigen | -0.0212627 |
| SDCBP | syndecan binding protein (syntenin) | -0.0211556 |
| LOXL3 | lysyl oxidase-like 3 | -0.0210266 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0210059 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0208887 |
| EVI5 | ecotropic viral integration site 5 | -0.0205574 |
| TMEM263 | transmembrane protein 263 | -0.0204147 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0203906 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0203512 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0198901 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0198143 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0194366 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0193796 |
| RPLP0 | ribosomal protein, large, P0 | -0.0192938 |
| MZT1 | mitotic spindle organizing protein 1 | -0.0192351 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0189912 |
| ABI1 | abl-interactor 1 | -0.0189689 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0186681 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0185738 |
