| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.222002 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.163287 |
| HLA-B | major histocompatibility complex, class I, B | 0.149717 |
| ADM | adrenomedullin | 0.118523 |
| PGK1 | phosphoglycerate kinase 1 | 0.108723 |
| VEGFA | vascular endothelial growth factor A | 0.107832 |
| HLA-A | major histocompatibility complex, class I, A | 0.101501 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0995875 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0977612 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0956174 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0791443 |
| RPL23 | ribosomal protein L23 | 0.078471 |
| ATP13A3 | ATPase type 13A3 | 0.0753264 |
| GOLGA4 | golgin A4 | 0.0749448 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0741279 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0696808 |
| RPS6 | ribosomal protein S6 | 0.0696127 |
| SFTPA2 | surfactant protein A2 | 0.0658193 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0657339 |
| CADM1 | cell adhesion molecule 1 | 0.065567 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.063374 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0607719 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0582534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0570676 |
| MSN | moesin | 0.0566479 |
| RPS3 | ribosomal protein S3 | 0.055914 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0554173 |
| ANKRD11 | ankyrin repeat domain 11 | 0.05531 |
| OPTN | optineurin | 0.0544168 |
| RPS12 | ribosomal protein S12 | 0.0524244 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0516069 |
| HELZ | helicase with zinc finger | 0.0513567 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0510453 |
| FMNL2 | formin-like 2 | 0.0494355 |
| ZNF292 | zinc finger protein 292 | 0.0493319 |
| PCBP2 | poly(rC) binding protein 2 | 0.0484919 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0484263 |
| PDE10A | phosphodiesterase 10A | 0.0477344 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0477103 |
| ACTG1 | actin gamma 1 | 0.0474364 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0473399 |
| OGA | O-GlcNAcase | 0.0472916 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0458987 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.045331 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0449383 |
| NONO | non-POU domain containing, octamer-binding | 0.0447331 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0435242 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0422296 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0420916 |
| CALR | calreticulin | 0.0414199 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0412868 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0409726 |
| NAV2 | neuron navigator 2 | 0.0406097 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0405122 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0403387 |
| MATR3 | matrin 3 | 0.040225 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0398171 |
| RPL37A | ribosomal protein L37a | 0.0396653 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0390969 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0390827 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0390313 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0387541 |
| TMSB4X | thymosin beta 4, X-linked | 0.0387155 |
| CDK19 | cyclin-dependent kinase 19 | 0.0386024 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0382922 |
| STC2 | stanniocalcin 2 | 0.0378033 |
| POTEF | POTE ankyrin domain family, member F | 0.0378029 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0378023 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0377881 |
| RPL11 | ribosomal protein L11 | 0.0377283 |
| BRD2 | bromodomain containing 2 | 0.037486 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0373395 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0373019 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0364698 |
| RND3 | Rho family GTPase 3 | 0.0361811 |
| CDH13 | cadherin 13 | 0.0352614 |
| WAC | WW domain containing adaptor with coiled-coil | 0.03519 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0349246 |
| RPL7A | ribosomal protein L7a | 0.0348061 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0347753 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346841 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0342921 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0340647 |
| PLIN2 | perilipin 2 | 0.0337223 |
| SNX9 | sorting nexin 9 | 0.0337021 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0332893 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0331039 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0323804 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0322311 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0316737 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0316113 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0315697 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0315009 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0314653 |
| B2M | beta-2-microglobulin | 0.0313231 |
| INSIG1 | insulin induced gene 1 | 0.0311495 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0311339 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0310077 |
| SETD5 | SET domain containing 5 | 0.0309886 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0309731 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.171586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110875 |
| VCL | vinculin | -0.102954 |
| CD44 | CD44 molecule (Indian blood group) | -0.096567 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0898865 |
| BICC1 | BicC family RNA binding protein 1 | -0.0886265 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0837912 |
| FRMD4A | FERM domain containing 4A | -0.0794523 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0764917 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0701181 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0690628 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0656053 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.063276 |
| IER3 | immediate early response 3 | -0.0625398 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0587263 |
| NABP1 | nucleic acid binding protein 1 | -0.0577559 |
| GLIS3 | GLIS family zinc finger 3 | -0.0576946 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0572808 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0560943 |
| OSMR | oncostatin M receptor | -0.0558877 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0556573 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.054231 |
| KLF6 | Kruppel-like factor 6 | -0.0495272 |
| VIM | vimentin | -0.0486696 |
| RIGI | RNA sensor RIG-I | -0.0420715 |
| MKI67 | marker of proliferation Ki-67 | -0.038551 |
| RRBP1 | ribosome binding protein 1 | -0.0385064 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0372319 |
| RTN4 | reticulon 4 | -0.0365629 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0355378 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0347075 |
| SP100 | SP100 nuclear antigen | -0.0344709 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0338869 |
| MX1 | MX dynamin-like GTPase 1 | -0.0338718 |
| NAV1 | neuron navigator 1 | -0.0337567 |
| RNF213 | ring finger protein 213 | -0.0332294 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0325883 |
| GPC6 | glypican 6 | -0.0321982 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0315225 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0307325 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0305966 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0305913 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0303213 |
| HMGA2 | high mobility group AT-hook 2 | -0.0300924 |
| TNS3 | tensin 3 | -0.0289196 |
| THBS1 | thrombospondin 1 | -0.0282041 |
| RAD51B | RAD51 paralog B | -0.0280561 |
| FAM20C | family with sequence similarity 20, member C | -0.0276495 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0275609 |
| EHBP1 | EH domain binding protein 1 | -0.0271586 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0267519 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0266643 |
| HDAC9 | histone deacetylase 9 | -0.0261065 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.025945 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0258249 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0254949 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0251844 |
| SYAP1 | synapse associated protein 1 | -0.0251397 |
| RPS24 | ribosomal protein S24 | -0.0250441 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0245785 |
| STK17A | serine/threonine kinase 17a | -0.0245249 |
| MX2 | MX dynamin-like GTPase 2 | -0.0244418 |
| THBS2 | thrombospondin 2 | -0.0242295 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0241448 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.023899 |
| MT2A | metallothionein 2A | -0.0234265 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.023177 |
| XAF1 | XIAP associated factor 1 | -0.0229838 |
| CDCP1 | CUB domain containing protein 1 | -0.0229837 |
| CLIC4 | chloride intracellular channel 4 | -0.022887 |
| AHNAK | AHNAK nucleoprotein | -0.0226675 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0223425 |
| EGR1 | early growth response 1 | -0.0221214 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0220574 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0219131 |
| COL1A1 | collagen, type I, alpha 1 | -0.0218547 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0218251 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0218117 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0217563 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.021644 |
| GNAS | GNAS complex locus | -0.0215855 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.021576 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.02137 |
| SDC4 | syndecan 4 | -0.0213127 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0213014 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.021228 |
| LOX | lysyl oxidase | -0.021068 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0209505 |
| KLHL5 | kelch-like family member 5 | -0.0207738 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0204842 |
| FBXO11 | F-box protein 11 | -0.0204036 |
| FRMD5 | FERM domain containing 5 | -0.020401 |
| DIAPH2 | diaphanous-related formin 2 | -0.0202928 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0202031 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0199486 |
| PLSCR1 | phospholipid scramblase 1 | -0.019489 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0194851 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0193282 |
| ETV6 | ets variant 6 | -0.019264 |
| STC1 | stanniocalcin 1 | -0.0192239 |
