Irinotecan (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.203498
LOC112694756 uncharaterized LOC112694756 0.122292
MYH9 myosin, heavy chain 9, non-muscle 0.121093
HLA-B major histocompatibility complex, class I, B 0.0941898
FAM13A family with sequence similarity 13, member A 0.0901918
HOOK2 hook microtubule-tethering protein 2 0.0888692
ARRDC3 arrestin domain containing 3 0.0781359
ANKRD11 ankyrin repeat domain 11 0.0717385
PGK1 phosphoglycerate kinase 1 0.0701707
PDE4D phosphodiesterase 4D, cAMP-specific 0.0682863
PRELID2 PRELI domain containing 2 0.0682383
NDRG1 N-myc downstream regulated 1 0.0665256
HLA-A major histocompatibility complex, class I, A 0.0649502
OGA O-GlcNAcase 0.0605769
AVL9 AVL9 homolog (S. cerevisiase) 0.0604691
KMT2E lysine (K)-specific methyltransferase 2E 0.0575868
TENT5A terminal nucleotidyltransferase 5A 0.0540619
EIF1 eukaryotic translation initiation factor 1 0.0533193
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0521131
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0500943
ERRFI1 ERBB receptor feedback inhibitor 1 0.0498522
PLEC plectin 0.049317
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0489202
XPO1 exportin 1 0.0479348
ZNF292 zinc finger protein 292 0.047178
RBM25 RNA binding motif protein 25 0.0468403
ELL2 elongation factor, RNA polymerase II, 2 0.0467981
ANLN anillin, actin binding protein 0.0464981
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0459538
ANXA2 annexin A2 0.0451952
GOLGA4 golgin A4 0.0428091
ZNF395 zinc finger protein 395 0.0420635
YEATS2 YEATS domain containing 2 0.0416006
TRA2A transformer 2 alpha homolog (Drosophila) 0.0410352
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0406221
FTL ferritin, light polypeptide 0.0401972
GSE1 Gse1 coiled-coil protein 0.0401573
HLA-C major histocompatibility complex, class I, C 0.0394963
TMSB4X thymosin beta 4, X-linked 0.0387038
TTC3 tetratricopeptide repeat domain 3 0.0383704
RPL34 ribosomal protein L34 0.0381478
CALR calreticulin 0.0380759
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0379544
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0378972
LGALS3 lectin, galactoside-binding, soluble, 3 0.037706
SHB Src homology 2 domain containing adaptor protein B 0.0376162
MORF4L1 mortality factor 4 like 1 0.0367574
NAV2 neuron navigator 2 0.0363982
TMED9 transmembrane emp24 protein transport domain containing 9 0.0361841
SQSTM1 sequestosome 1 0.0361125
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0356615
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0344639
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0339417
DLG1 discs, large homolog 1 (Drosophila) 0.033026
SND1 staphylococcal nuclease and tudor domain containing 1 0.0329494
N4BP2L2 NEDD4 binding protein 2-like 2 0.0324591
HDLBP high density lipoprotein binding protein 0.0324588
SERINC1 serine incorporator 1 0.0319679
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0319077
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0317665
RPLP2 ribosomal protein, large, P2 0.0311787
MARCHF6 membrane associated ring-CH-type finger 6 0.0305149
AOPEP aminopeptidase O (putative) 0.0300692
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0299922
KDM3A lysine (K)-specific demethylase 3A 0.0298562
H3-3B H3.3 histone B 0.0297491
MYOF myoferlin 0.0296047
NALF1 NALCN channel auxiliary factor 1 0.0293551
LOXL2 lysyl oxidase-like 2 0.0292466
ZMIZ1 zinc finger, MIZ-type containing 1 0.029232
DDIT4 DNA-damage-inducible transcript 4 0.028947
ADM adrenomedullin 0.0288179
YTHDC1 YTH domain containing 1 0.0286311
FLNA filamin A, alpha 0.0285434
EIF4H eukaryotic translation initiation factor 4H 0.0283887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0278622
CTSA cathepsin A 0.027826
RPL37 ribosomal protein L37 0.0277396
MBNL2 muscleblind-like splicing regulator 2 0.0277242
MACF1 microtubule-actin crosslinking factor 1 0.0277077
SFTPA2 surfactant protein A2 0.0275672
RPS3 ribosomal protein S3 0.0274123
TPM3 tropomyosin 3 0.0272834
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0271549
WSB1 WD repeat and SOCS box containing 1 0.0267556
TPI1 triosephosphate isomerase 1 0.0266059
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0265425
RNF145 ring finger protein 145 0.0263523
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0262332
GNPDA1 glucosamine-6-phosphate deaminase 1 0.026116
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0259799
ANKRD36 ankyrin repeat domain 36 0.0259511
CRLS1 cardiolipin synthase 1 0.025945
NOP58 NOP58 ribonucleoprotein 0.0258849
RPS8 ribosomal protein S8 0.0258677
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0256897
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0255963
TMF1 TATA element modulatory factor 1 0.0255279
PDIA4 protein disulfide isomerase family A, member 4 0.0253796
CALU calumenin 0.0250694

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.161545
IGFBP3 insulin-like growth factor binding protein 3 -0.118121
CXCL8 chemokine (C-X-C motif) ligand 8 -0.109382
LOX lysyl oxidase -0.109099
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.101642
FN1 fibronectin 1 -0.0906374
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0877178
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0848163
CDH13 cadherin 13 -0.0820653
VCL vinculin -0.0767567
TMSB10 thymosin beta 10 -0.0760572
IL6 interleukin 6 -0.0740092
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0711268
VIM vimentin -0.0693112
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0680776
MAP1B microtubule-associated protein 1B -0.0642481
POTEF POTE ankyrin domain family, member F -0.0627408
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0620112
RTN4 reticulon 4 -0.0596083
F3 coagulation factor III (thromboplastin, tissue factor) -0.0580564
FNDC3B fibronectin type III domain containing 3B -0.0558907
PDIA3 protein disulfide isomerase family A, member 3 -0.0550285
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0547779
RAI14 retinoic acid induced 14 -0.0547597
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0532397
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0521652
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0519214
GRB10 growth factor receptor-bound protein 10 -0.0515168
IL6ST interleukin 6 signal transducer -0.050244
TNS3 tensin 3 -0.0476141
AKAP12 A kinase (PRKA) anchor protein 12 -0.047544
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0472061
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0466967
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0448834
PDLIM5 PDZ and LIM domain 5 -0.0444592
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0437454
SDC4 syndecan 4 -0.043629
COL6A1 collagen, type VI, alpha 1 -0.0434737
SPAG9 sperm associated antigen 9 -0.0422178
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0421169
GLIS3 GLIS family zinc finger 3 -0.0418219
GLS2 glutaminase 2 (liver, mitochondrial) -0.0412175
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0408841
FTH1 ferritin, heavy polypeptide 1 -0.0408042
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0407653
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0389971
NAV1 neuron navigator 1 -0.0386888
VEGFC vascular endothelial growth factor C -0.037965
RASAL2 RAS protein activator like 2 -0.0375676
ACTG1 actin gamma 1 -0.0374897
COL1A2 collagen, type I, alpha 2 -0.0363237
CARD16 caspase recruitment domain family, member 16 -0.035911
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0356393
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0356052
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0355581
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0349894
CD44 CD44 molecule (Indian blood group) -0.0348447
ENO1 enolase 1, (alpha) -0.0348165
HMGA2 high mobility group AT-hook 2 -0.034599
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0345669
ADAM9 ADAM metallopeptidase domain 9 -0.0345491
ZFAND3 zinc finger, AN1-type domain 3 -0.0344498
SOD2 superoxide dismutase 2, mitochondrial -0.0343426
CDK6 cyclin-dependent kinase 6 -0.0342671
NABP1 nucleic acid binding protein 1 -0.0342404
MCL1 myeloid cell leukemia 1 -0.0340075
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0335989
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0330186
FAM3C family with sequence similarity 3, member C -0.0329951
SPDYA speedy/RINGO cell cycle regulator family member A -0.0327677
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0326307
ARF4 ADP-ribosylation factor 4 -0.032198
INHBA inhibin, beta A -0.0321318
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0320181
QKI QKI, KH domain containing, RNA binding -0.0319774
LDHA lactate dehydrogenase A -0.0317758
ITGAV integrin, alpha V -0.0317536
FBXO11 F-box protein 11 -0.0316987
AUTS2 autism susceptibility candidate 2 -0.0316235
IL7R interleukin 7 receptor -0.0313264
ZEB1 zinc finger E-box binding homeobox 1 -0.0310747
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0309662
WAC WW domain containing adaptor with coiled-coil -0.0309585
ALCAM activated leukocyte cell adhesion molecule -0.0308219
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0305762
PI3 peptidase inhibitor 3, skin-derived -0.0305599
EGFR epidermal growth factor receptor -0.0304598
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0304276
EXOC4 exocyst complex component 4 -0.0302598
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.030242
PRSS23 protease, serine, 23 -0.0299729
DTNA dystrobrevin, alpha -0.0298283
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0294501
LMAN1 lectin, mannose-binding, 1 -0.0292963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0292681
FNDC3A fibronectin type III domain containing 3A -0.0288191
JUN jun proto-oncogene -0.0287539
ERLEC1 endoplasmic reticulum lectin 1 -0.0286267
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0282745
TPM1 tropomyosin 1 (alpha) -0.028236