Irinotecan (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0850593
GOLGA4 golgin A4 0.0849698
SMYD3 SET and MYND domain containing 3 0.0815785
MYH9 myosin, heavy chain 9, non-muscle 0.0807563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0719688
DSCAM Down syndrome cell adhesion molecule 0.0680138
EEF2 eukaryotic translation elongation factor 2 0.0675371
TOP2A topoisomerase (DNA) II alpha 170kDa 0.065339
WAC WW domain containing adaptor with coiled-coil 0.0640866
TPX2 TPX2, microtubule-associated 0.0634278
ATM ATM serine/threonine kinase 0.0620792
RAD51B RAD51 paralog B 0.0617143
NAP1L1 nucleosome assembly protein 1-like 1 0.0611692
CEP250 centrosomal protein 250kDa 0.0611073
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0594575
SETD5 SET domain containing 5 0.0583925
PDE8A phosphodiesterase 8A 0.0574195
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0571894
EIF1 eukaryotic translation initiation factor 1 0.0562189
ANKRD11 ankyrin repeat domain 11 0.0551779
SRRM2 serine/arginine repetitive matrix 2 0.0539405
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.051409
RPL37 ribosomal protein L37 0.0493978
RBM25 RNA binding motif protein 25 0.0485701
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0460954
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0451588
SET SET nuclear proto-oncogene 0.0450648
KIAA1328 KIAA1328 0.0438671
RPL26 ribosomal protein L26 0.0433244
RPS12 ribosomal protein S12 0.042669
SEPTIN2 septin 2 0.0425554
NUMA1 nuclear mitotic apparatus protein 1 0.041836
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0413379
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0412936
TNIP1 TNFAIP3 interacting protein 1 0.040955
AKAP13 A kinase (PRKA) anchor protein 13 0.0400893
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0394477
MRE11 MRE11 homolog, double strand break repair nuclease 0.0390186
XPO1 exportin 1 0.0389224
RBM39 RNA binding motif protein 39 0.0386214
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0384675
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0384408
TAS2R14 taste receptor, type 2, member 14 0.0384371
SBNO1 strawberry notch homolog 1 (Drosophila) 0.038313
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0381131
CKAP5 cytoskeleton associated protein 5 0.037511
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.037144
RPL4 ribosomal protein L4 0.0370837
APOLD1 apolipoprotein L domain containing 1 0.0366916
ITCH itchy E3 ubiquitin protein ligase 0.0364787
MSN moesin 0.0363672
ATP13A3 ATPase type 13A3 0.0359649
PNISR PNN-interacting serine/arginine-rich protein 0.0358604
UVRAG UV radiation resistance associated 0.0353401
TBC1D5 TBC1 domain family, member 5 0.0352547
GIGYF2 GRB10 interacting GYF protein 2 0.0350718
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0347003
KANSL1 KAT8 regulatory NSL complex subunit 1 0.034375
H1-4 H1.4 linker histone, cluster member 0.0343634
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0339583
EIF4B eukaryotic translation initiation factor 4B 0.033692
RPL9 ribosomal protein L9 0.0335383
RORA RAR-related orphan receptor A 0.0333661
PRPF4B pre-mRNA processing factor 4B 0.0327194
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0324986
RPL37A ribosomal protein L37a 0.0320788
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0319029
DIAPH3 diaphanous-related formin 3 0.0318077
BABAM2 BRISC and BRCA1 A complex member 2 0.0317618
BCLAF1 BCL2-associated transcription factor 1 0.0317349
TM9SF2 transmembrane 9 superfamily member 2 0.0317333
KIAA1958 KIAA1958 0.0315252
RPS17 ribosomal protein S17 0.0315174
ZNF609 zinc finger protein 609 0.0308601
ZNF292 zinc finger protein 292 0.0306808
NCOR1 nuclear receptor corepressor 1 0.0305952
GARS1 glycyl-tRNA synthetase 1 0.030532
TRIO trio Rho guanine nucleotide exchange factor 0.0304217
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0303827
USP47 ubiquitin specific peptidase 47 0.0301768
EIF4H eukaryotic translation initiation factor 4H 0.0300772
AVL9 AVL9 homolog (S. cerevisiase) 0.0300346
AKAP9 A kinase (PRKA) anchor protein 9 0.0298653
ATXN2 ataxin 2 0.0297865
NACA nascent polypeptide-associated complex alpha subunit 0.0297356
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0296821
NCAPD2 non-SMC condensin I complex, subunit D2 0.0296224
RPS27A ribosomal protein S27a 0.0296011
TNRC18 trinucleotide repeat containing 18 0.0292465
RPL23 ribosomal protein L23 0.0292065
SEC24A SEC24 family member A 0.0290422
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.028773
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0286275
PCBP2 poly(rC) binding protein 2 0.0284587
RAB6A RAB6A, member RAS oncogene family 0.0284198
FOXJ3 forkhead box J3 0.0283685
UBE2O ubiquitin-conjugating enzyme E2O 0.0282427
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0282084
ERBIN erbb2 interacting protein 0.0281267
CENPE centromere protein E, 312kDa 0.0281047

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.245563
TMSB10 thymosin beta 10 -0.0853684
FNDC3B fibronectin type III domain containing 3B -0.0833309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0764427
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.068247
MT2A metallothionein 2A -0.0668958
ANXA2 annexin A2 -0.0627448
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0600178
HMGA2 high mobility group AT-hook 2 -0.0524718
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0514423
TM4SF1 transmembrane 4 L six family member 1 -0.0477983
LDHA lactate dehydrogenase A -0.0467134
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0465499
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0455809
SVIL supervillin -0.0430315
POTEF POTE ankyrin domain family, member F -0.0416133
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0413125
IER3 immediate early response 3 -0.0402023
AKAP12 A kinase (PRKA) anchor protein 12 -0.0390551
RPLP1 ribosomal protein, large, P1 -0.0389143
SLC38A2 solute carrier family 38, member 2 -0.0387907
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0387166
CD44 CD44 molecule (Indian blood group) -0.0372742
FTL ferritin, light polypeptide -0.0368482
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0368301
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0367908
ANGPTL4 angiopoietin-like 4 -0.0366696
NCEH1 neutral cholesterol ester hydrolase 1 -0.0360431
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348166
TMEM123 transmembrane protein 123 -0.0346491
TPT1 tumor protein, translationally-controlled 1 -0.0339008
H3-3B H3.3 histone B -0.0338899
RPL35A ribosomal protein L35a -0.0338649
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0336777
RIGI RNA sensor RIG-I -0.0331046
INSIG1 insulin induced gene 1 -0.0331041
SETX senataxin -0.0328997
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0327419
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0326881
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0325968
IGFBP3 insulin-like growth factor binding protein 3 -0.0323826
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0323253
SNX14 sorting nexin 14 -0.0316344
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314577
IL1RAP interleukin 1 receptor accessory protein -0.0311185
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.03096
PODXL podocalyxin-like -0.0308661
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0304509
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0298272
KLF6 Kruppel-like factor 6 -0.0296577
NDRG1 N-myc downstream regulated 1 -0.0294257
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0290389
SASH1 SAM and SH3 domain containing 1 -0.0286247
NT5E 5'-nucleotidase, ecto (CD73) -0.0284893
OSMR oncostatin M receptor -0.0283219
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0279094
RAI14 retinoic acid induced 14 -0.027829
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0277752
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0273096
FMN1 formin 1 -0.0271632
FAM177A1 family with sequence similarity 177, member A1 -0.0269441
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0268882
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0263876
MARCKS myristoylated alanine-rich protein kinase C substrate -0.026375
KTN1 kinectin 1 (kinesin receptor) -0.0260904
LDLR low density lipoprotein receptor -0.026037
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0259951
FAM3C family with sequence similarity 3, member C -0.0259939
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0257366
SDC4 syndecan 4 -0.0257305
ANO6 anoctamin 6 -0.0256901
SH3KBP1 SH3-domain kinase binding protein 1 -0.0254421
EPAS1 endothelial PAS domain protein 1 -0.0253509
PRSS23 protease, serine, 23 -0.0248039
CAVIN1 caveolae associated protein 1 -0.0247593
VIM vimentin -0.0244654
IL6ST interleukin 6 signal transducer -0.0243898
NPC1 Niemann-Pick disease, type C1 -0.024328
ANKRD37 ankyrin repeat domain 37 -0.023494
FTH1 ferritin, heavy polypeptide 1 -0.0234642
PDGFA platelet-derived growth factor alpha polypeptide -0.0232885
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0231729
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0231067
PRR16 proline rich 16 -0.0230831
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0227591
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0226903
PFN1 profilin 1 -0.0225222
LMAN1 lectin, mannose-binding, 1 -0.0225204
BTG1 B-cell translocation gene 1, anti-proliferative -0.0225072
ISG15 ISG15 ubiquitin-like modifier -0.0222964
CCND1 cyclin D1 -0.0220209
OASL 2'-5'-oligoadenylate synthetase-like -0.0220185
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0218813
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0218005
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0217618
UGCG UDP-glucose ceramide glucosyltransferase -0.0217607
KDM3A lysine (K)-specific demethylase 3A -0.0217398
DTNA dystrobrevin, alpha -0.0215866
JUND jun D proto-oncogene -0.0215611
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0214941