| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.137933 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.128565 |
| STC2 | stanniocalcin 2 | 0.105267 |
| CD109 | CD109 molecule | 0.0994288 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0903763 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0872558 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0838699 |
| B2M | beta-2-microglobulin | 0.0816217 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.081021 |
| HLA-B | major histocompatibility complex, class I, B | 0.0784111 |
| FAM13A | family with sequence similarity 13, member A | 0.0761568 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0741335 |
| SFTPA2 | surfactant protein A2 | 0.0719253 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0713136 |
| RNF145 | ring finger protein 145 | 0.0706885 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0671149 |
| OGA | O-GlcNAcase | 0.0572798 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0562815 |
| TPM3 | tropomyosin 3 | 0.0549849 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0539344 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0523929 |
| ZNF292 | zinc finger protein 292 | 0.052287 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0522696 |
| HLA-A | major histocompatibility complex, class I, A | 0.0518041 |
| PTK2 | protein tyrosine kinase 2 | 0.0515927 |
| ANKRD11 | ankyrin repeat domain 11 | 0.051495 |
| HDGF | hepatoma-derived growth factor | 0.0505802 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0504526 |
| TXNIP | thioredoxin interacting protein | 0.0500259 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0484362 |
| HELZ | helicase with zinc finger | 0.0473625 |
| PKM | pyruvate kinase, muscle | 0.0470571 |
| GOLGA4 | golgin A4 | 0.0465207 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0445299 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0444918 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0443312 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0437285 |
| TMSB4X | thymosin beta 4, X-linked | 0.0433385 |
| YME1L1 | YME1-like 1 ATPase | 0.0430051 |
| VEGFA | vascular endothelial growth factor A | 0.0429744 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.042277 |
| RPS6 | ribosomal protein S6 | 0.0421295 |
| DENND5B | DENN/MADD domain containing 5B | 0.0408165 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0408057 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0407647 |
| INSIG2 | insulin induced gene 2 | 0.04075 |
| TPI1 | triosephosphate isomerase 1 | 0.0403303 |
| PTMA | prothymosin, alpha | 0.0399982 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.03976 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0397297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0395968 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0394099 |
| PGK1 | phosphoglycerate kinase 1 | 0.0392397 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0392319 |
| XPO1 | exportin 1 | 0.03903 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0385731 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0384551 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0381668 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0378285 |
| APP | amyloid beta (A4) precursor protein | 0.0377638 |
| COPA | coatomer protein complex, subunit alpha | 0.0374229 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0372903 |
| RPS12 | ribosomal protein S12 | 0.0370929 |
| CTBP2 | C-terminal binding protein 2 | 0.0370869 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0365415 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0360926 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0360691 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0354867 |
| RBM39 | RNA binding motif protein 39 | 0.0354474 |
| SUCO | SUN domain containing ossification factor | 0.0354291 |
| WDR45B | WD repeat domain 45B | 0.0351663 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0348636 |
| SMYD3 | SET and MYND domain containing 3 | 0.0347814 |
| RBM33 | RNA binding motif protein 33 | 0.0344612 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0343037 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0342555 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0341429 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0338177 |
| SETD5 | SET domain containing 5 | 0.0335597 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0335339 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0334591 |
| SRPK2 | SRSF protein kinase 2 | 0.0332653 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.033226 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0328854 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0326899 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0323197 |
| DSTN | destrin (actin depolymerizing factor) | 0.0322846 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0320581 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0319199 |
| NOP58 | NOP58 ribonucleoprotein | 0.0318872 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0315663 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0312471 |
| TPD52 | tumor protein D52 | 0.0310292 |
| WDR43 | WD repeat domain 43 | 0.0308218 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0308202 |
| FOXJ3 | forkhead box J3 | 0.0305563 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0302709 |
| RPS3 | ribosomal protein S3 | 0.0300596 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0297915 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0294423 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.305997 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.161616 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.152783 |
| EXT1 | exostosin glycosyltransferase 1 | -0.147603 |
| VCL | vinculin | -0.110174 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0926234 |
| HMGA2 | high mobility group AT-hook 2 | -0.0829314 |
| OSMR | oncostatin M receptor | -0.0708143 |
| ITGA1 | integrin, alpha 1 | -0.0638388 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.061255 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0555365 |
| MT2A | metallothionein 2A | -0.0543608 |
| ASPH | aspartate beta-hydroxylase | -0.0531263 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0527446 |
| NTN4 | netrin 4 | -0.0448648 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0448163 |
| IER3 | immediate early response 3 | -0.0443078 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0430161 |
| RAB31 | RAB31, member RAS oncogene family | -0.0411624 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0399095 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0395794 |
| FTL | ferritin, light polypeptide | -0.0385036 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.037432 |
| NRP1 | neuropilin 1 | -0.0372347 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0370468 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0362834 |
| KSR1 | kinase suppressor of ras 1 | -0.0359093 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0354537 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0354073 |
| PALLD | palladin, cytoskeletal associated protein | -0.0349359 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0344683 |
| FHL2 | four and a half LIM domains 2 | -0.0342713 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0333161 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0324269 |
| INTS6 | integrator complex subunit 6 | -0.0304021 |
| EGR1 | early growth response 1 | -0.0286099 |
| PELO | pelota homolog (Drosophila) | -0.0283983 |
| IL6ST | interleukin 6 signal transducer | -0.0282093 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.02702 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0267369 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0264904 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0260442 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0258306 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.025545 |
| NDRG1 | N-myc downstream regulated 1 | -0.0253756 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0251727 |
| SVIL | supervillin | -0.0245233 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0243304 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0242437 |
| ZNF644 | zinc finger protein 644 | -0.0235984 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0233718 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0232699 |
| MYO1E | myosin IE | -0.0225015 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0222322 |
| LRRC23 | leucine rich repeat containing 23 | -0.0221349 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0220905 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0218007 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0217553 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0215506 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0215281 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0209668 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0203208 |
| TNNC1 | troponin C type 1 (slow) | -0.0202806 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0202429 |
| GLIS3 | GLIS family zinc finger 3 | -0.020179 |
| THBS1 | thrombospondin 1 | -0.0199482 |
| GOLGB1 | golgin B1 | -0.0198174 |
| CD44 | CD44 molecule (Indian blood group) | -0.0195407 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0193307 |
| TGFA | transforming growth factor, alpha | -0.0188883 |
| SP100 | SP100 nuclear antigen | -0.0187685 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0185391 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0183676 |
| RPS24 | ribosomal protein S24 | -0.0182844 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0180587 |
| TOP1 | topoisomerase (DNA) I | -0.0180329 |
| HMGA1 | high mobility group AT-hook 1 | -0.0178454 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.017812 |
| LOXL2 | lysyl oxidase-like 2 | -0.017793 |
| VIM | vimentin | -0.0176358 |
| TMEM263 | transmembrane protein 263 | -0.0170359 |
| VCAN | versican | -0.017006 |
| GLCCI1 | glucocorticoid induced 1 | -0.0169131 |
| RPLP1 | ribosomal protein, large, P1 | -0.0167036 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0166671 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0164983 |
| FAM20C | family with sequence similarity 20, member C | -0.0163931 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0161127 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.015785 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0156085 |
| ARF1 | ADP-ribosylation factor 1 | -0.0155966 |
| LOX | lysyl oxidase | -0.0155311 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0155198 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0153794 |
| ACTN1 | actinin, alpha 1 | -0.0152003 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0151142 |
| NXN | nucleoredoxin | -0.0150457 |
| RBPMS | RNA binding protein with multiple splicing | -0.0149572 |
| NABP1 | nucleic acid binding protein 1 | -0.0149509 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0149412 |
