| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT18 | keratin 18, type I | 0.128106 |
| KRT8 | keratin 8, type II | 0.102119 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0932158 |
| PLEC | plectin | 0.0895609 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0895416 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0888628 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0801113 |
| RPS6 | ribosomal protein S6 | 0.0736596 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0691933 |
| NDRG1 | N-myc downstream regulated 1 | 0.068919 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0677475 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0665652 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0644579 |
| HLA-A | major histocompatibility complex, class I, A | 0.0637453 |
| PRELID2 | PRELI domain containing 2 | 0.0625952 |
| TMSB4X | thymosin beta 4, X-linked | 0.0625265 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0598549 |
| RPS21 | ribosomal protein S21 | 0.0558571 |
| RPS3 | ribosomal protein S3 | 0.0531396 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0529291 |
| PGK1 | phosphoglycerate kinase 1 | 0.0528786 |
| ZNRF3 | zinc and ring finger 3 | 0.0526926 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0520059 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0518931 |
| PTMA | prothymosin, alpha | 0.0513776 |
| SETD5 | SET domain containing 5 | 0.0495566 |
| USP3 | ubiquitin specific peptidase 3 | 0.0475763 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0475475 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0469437 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0465263 |
| MSI2 | musashi RNA-binding protein 2 | 0.0447426 |
| RPL35A | ribosomal protein L35a | 0.0444877 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0436841 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0429704 |
| ANXA11 | annexin A11 | 0.0421933 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0419523 |
| THOC2 | THO complex 2 | 0.0402168 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0398605 |
| AFDN | afadin, adherens junction formation factor | 0.038986 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0385017 |
| RNF43 | ring finger protein 43 | 0.038147 |
| DEK | DEK proto-oncogene | 0.037937 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0369555 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0365729 |
| RNF149 | ring finger protein 149 | 0.0364134 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.036194 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0357908 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0357045 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0351261 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0349694 |
| RPL7A | ribosomal protein L7a | 0.0349443 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0347211 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0344964 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0344224 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0343833 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0343768 |
| CXXC5 | CXXC finger protein 5 | 0.0341477 |
| HOXB6 | homeobox B6 | 0.0340687 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0339157 |
| DNM2 | dynamin 2 | 0.033858 |
| RPL11 | ribosomal protein L11 | 0.0338535 |
| HOXA3 | homeobox A3 | 0.033329 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0332094 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0331753 |
| RPL37 | ribosomal protein L37 | 0.0330547 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0327929 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0327885 |
| ADM | adrenomedullin | 0.0327604 |
| RREB1 | ras responsive element binding protein 1 | 0.0326897 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0326544 |
| STC2 | stanniocalcin 2 | 0.032648 |
| RPS12 | ribosomal protein S12 | 0.0321873 |
| RPL37A | ribosomal protein L37a | 0.0320283 |
| HOXB3 | homeobox B3 | 0.0319759 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0314785 |
| VEGFA | vascular endothelial growth factor A | 0.0310597 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | 0.0309968 |
| PRELID3B | PRELI domain containing 3B | 0.0307902 |
| OXR1 | oxidation resistance 1 | 0.0305926 |
| FRMD5 | FERM domain containing 5 | 0.0301956 |
| NFIA | nuclear factor I/A | 0.0300972 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0297928 |
| YEATS2 | YEATS domain containing 2 | 0.0297523 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0296819 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0294982 |
| KIAA1671 | KIAA1671 | 0.02937 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0292923 |
| TCERG1 | transcription elongation regulator 1 | 0.0292362 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0291309 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0288353 |
| RPLP2 | ribosomal protein, large, P2 | 0.0286989 |
| DIDO1 | death inducer-obliterator 1 | 0.0285059 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0283152 |
| HLA-B | major histocompatibility complex, class I, B | 0.0282467 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0282315 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0281926 |
| RPL13A | ribosomal protein L13a | 0.0281195 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0281135 |
| FLNA | filamin A, alpha | 0.0274676 |
| ATP9A | ATPase, class II, type 9A | 0.027399 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.167978 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.166958 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156642 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119823 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.103111 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.091451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0885897 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0874053 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0821448 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0794787 |
| ANXA2 | annexin A2 | -0.0744019 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0737788 |
| CANX | calnexin | -0.0736818 |
| VCL | vinculin | -0.0731077 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0689756 |
| MYO1E | myosin IE | -0.0687328 |
| EGR1 | early growth response 1 | -0.0683333 |
| GOLGB1 | golgin B1 | -0.0617196 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0589865 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0564941 |
| RPS27A | ribosomal protein S27a | -0.0562801 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0544477 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0533383 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0526758 |
| LDHA | lactate dehydrogenase A | -0.0504472 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0494527 |
| RYBP | RING1 and YY1 binding protein | -0.049034 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0489361 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0488794 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0484936 |
| GNAS | GNAS complex locus | -0.0481949 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0459828 |
| TMSB10 | thymosin beta 10 | -0.0444794 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0444313 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0440906 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0437896 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0429808 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0428061 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0425167 |
| IER3 | immediate early response 3 | -0.0419471 |
| TMEM123 | transmembrane protein 123 | -0.0398689 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0397011 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0391617 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0389644 |
| TGFA | transforming growth factor, alpha | -0.0387314 |
| FTL | ferritin, light polypeptide | -0.0380009 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0376775 |
| IPO7 | importin 7 | -0.0376042 |
| RHEB | Ras homolog enriched in brain | -0.0371352 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0364053 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0359042 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0354767 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.035474 |
| UBAP2 | ubiquitin associated protein 2 | -0.0352732 |
| MALT1 | MALT1 paracaspase | -0.0350132 |
| ECT2 | epithelial cell transforming 2 | -0.0345455 |
| ZNF207 | zinc finger protein 207 | -0.0343942 |
| RIGI | RNA sensor RIG-I | -0.0342057 |
| JUN | jun proto-oncogene | -0.0337831 |
| INTS6 | integrator complex subunit 6 | -0.0337497 |
| FBXO11 | F-box protein 11 | -0.0332704 |
| CALU | calumenin | -0.0330692 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0328376 |
| SETX | senataxin | -0.0327311 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0325805 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0325721 |
| POTEF | POTE ankyrin domain family, member F | -0.0325054 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0322148 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0320189 |
| PCBP2 | poly(rC) binding protein 2 | -0.0319884 |
| PERP | PERP, TP53 apoptosis effector | -0.0319074 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0317865 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317735 |
| OXSR1 | oxidative stress responsive 1 | -0.0312748 |
| WWC1 | WW and C2 domain containing 1 | -0.0311498 |
| PLSCR1 | phospholipid scramblase 1 | -0.0304875 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0301713 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0298698 |
| AHNAK | AHNAK nucleoprotein | -0.0297288 |
| TJP1 | tight junction protein 1 | -0.0297248 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0297178 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0294874 |
| HMGB2 | high mobility group box 2 | -0.0291192 |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 | -0.0288498 |
| HDAC9 | histone deacetylase 9 | -0.0284522 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0283759 |
| SP100 | SP100 nuclear antigen | -0.028274 |
| RCOR1 | REST corepressor 1 | -0.028163 |
| VMP1 | vacuole membrane protein 1 | -0.0281142 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0277923 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0277292 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.02735 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0272833 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0272104 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0269628 |
| ZNF217 | zinc finger protein 217 | -0.026931 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0269294 |
| ENO1 | enolase 1, (alpha) | -0.0267637 |
| CCND1 | cyclin D1 | -0.0266041 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0264539 |
