| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.111899 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0881211 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0862723 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0843556 |
| SNX9 | sorting nexin 9 | 0.0835766 |
| MED13L | mediator complex subunit 13-like | 0.0822757 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0810218 |
| RPS6 | ribosomal protein S6 | 0.0794977 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0787782 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0786176 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0767909 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0735738 |
| ATXN1 | ataxin 1 | 0.0730118 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0697919 |
| COG5 | component of oligomeric golgi complex 5 | 0.0691643 |
| RPS12 | ribosomal protein S12 | 0.06658 |
| MYO5B | myosin VB | 0.0665606 |
| USP3 | ubiquitin specific peptidase 3 | 0.0651128 |
| PTMA | prothymosin, alpha | 0.0641002 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0640416 |
| ZNF292 | zinc finger protein 292 | 0.0639692 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0637527 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0628959 |
| LAMB3 | laminin, beta 3 | 0.0625065 |
| NDRG1 | N-myc downstream regulated 1 | 0.061141 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0609221 |
| BBX | bobby sox homolog (Drosophila) | 0.0605695 |
| PARD3 | par-3 family cell polarity regulator | 0.0605389 |
| RUNX2 | runt-related transcription factor 2 | 0.0598361 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0594443 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.05919 |
| FLOT1 | flotillin 1 | 0.058329 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0580405 |
| FAT1 | FAT atypical cadherin 1 | 0.0575916 |
| SBF2 | SET binding factor 2 | 0.0568123 |
| NAV2 | neuron navigator 2 | 0.0553583 |
| RCOR1 | REST corepressor 1 | 0.0549646 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0544549 |
| RNF43 | ring finger protein 43 | 0.0525732 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0525481 |
| RPS3 | ribosomal protein S3 | 0.0525067 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0519776 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0518658 |
| NUP58 | nucleoporin 58 | 0.0512627 |
| FERMT1 | fermitin family member 1 | 0.0500743 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.049959 |
| TOP1 | topoisomerase (DNA) I | 0.0499516 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0493249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0479014 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0478736 |
| RPL26 | ribosomal protein L26 | 0.0477454 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0477117 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0474261 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0470054 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0469408 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0463288 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0458543 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0433268 |
| CCNY | cyclin Y | 0.0426412 |
| ACTN4 | actinin, alpha 4 | 0.0425439 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0420032 |
| HMGA1 | high mobility group AT-hook 1 | 0.0418116 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0416438 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0415497 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0407708 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0407197 |
| RPS17 | ribosomal protein S17 | 0.0405531 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0405004 |
| NCKAP1 | NCK-associated protein 1 | 0.0403571 |
| ZNRF3 | zinc and ring finger 3 | 0.040352 |
| RPL23 | ribosomal protein L23 | 0.0403407 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0402994 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.039626 |
| ENO1 | enolase 1, (alpha) | 0.039367 |
| CDC73 | cell division cycle 73 | 0.0392872 |
| RPL7A | ribosomal protein L7a | 0.0388042 |
| RPS8 | ribosomal protein S8 | 0.0387139 |
| RPL3 | ribosomal protein L3 | 0.0383857 |
| YAP1 | Yes-associated protein 1 | 0.0380484 |
| SIK3 | SIK family kinase 3 | 0.0379908 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.037243 |
| PGK1 | phosphoglycerate kinase 1 | 0.0370084 |
| RPL37A | ribosomal protein L37a | 0.0369482 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0369121 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0367382 |
| FLNA | filamin A, alpha | 0.0365835 |
| CDCP1 | CUB domain containing protein 1 | 0.0364702 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0363219 |
| ARFGEF3 | ARFGEF family member 3 | 0.0362935 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0359957 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0359666 |
| ANXA11 | annexin A11 | 0.0359516 |
| RPL11 | ribosomal protein L11 | 0.0358944 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0356636 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0352255 |
| RTN4 | reticulon 4 | 0.0350693 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.03447 |
| TES | testin LIM domain protein | 0.0342077 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0340309 |
| AHNAK | AHNAK nucleoprotein | 0.0338107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.193186 |
| LMO7 | LIM domain 7 | -0.170793 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.100476 |
| EGFR | epidermal growth factor receptor | -0.0901054 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0771982 |
| SERINC5 | serine incorporator 5 | -0.0676467 |
| ANXA1 | annexin A1 | -0.0661551 |
| HDAC2 | histone deacetylase 2 | -0.0639278 |
| VCL | vinculin | -0.0544117 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0506283 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0461523 |
| PHF14 | PHD finger protein 14 | -0.045235 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0438021 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0414957 |
| KITLG | KIT ligand | -0.040011 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0396733 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0396094 |
| EMP1 | epithelial membrane protein 1 | -0.0383041 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0377245 |
| MTAP | methylthioadenosine phosphorylase | -0.0375053 |
| LDHA | lactate dehydrogenase A | -0.0374376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0373948 |
| CANX | calnexin | -0.0372776 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0372127 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0370526 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0345676 |
| VMP1 | vacuole membrane protein 1 | -0.0344208 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0333145 |
| GDF15 | growth differentiation factor 15 | -0.0322488 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0319155 |
| OXR1 | oxidation resistance 1 | -0.0319027 |
| OXSR1 | oxidative stress responsive 1 | -0.0315693 |
| BPTF | bromodomain PHD finger transcription factor | -0.0307531 |
| S100A10 | S100 calcium binding protein A10 | -0.0299821 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0299639 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0293968 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0285912 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0283269 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0275016 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0270942 |
| R3HDM1 | R3H domain containing 1 | -0.0267547 |
| NABP1 | nucleic acid binding protein 1 | -0.0263957 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.026279 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0261588 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0256995 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0252719 |
| ARF1 | ADP-ribosylation factor 1 | -0.024895 |
| ATG7 | autophagy related 7 | -0.0247877 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0241506 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0241453 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0237747 |
| RBM25 | RNA binding motif protein 25 | -0.0236514 |
| AOPEP | aminopeptidase O (putative) | -0.0234673 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0232698 |
| ANXA3 | annexin A3 | -0.0227349 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0226138 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0224704 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0220637 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.021974 |
| FMN1 | formin 1 | -0.0219227 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0215671 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | -0.0215565 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0214092 |
| PLK2 | polo-like kinase 2 | -0.0213966 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0211153 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0210276 |
| UBE3C | ubiquitin protein ligase E3C | -0.0205495 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0202123 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0199579 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0199444 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.019651 |
| FTL | ferritin, light polypeptide | -0.019292 |
| TRAP1 | TNF receptor-associated protein 1 | -0.019195 |
| USP34 | ubiquitin specific peptidase 34 | -0.0191775 |
| MT1X | metallothionein 1X | -0.0190839 |
| TNS3 | tensin 3 | -0.0188432 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0185575 |
| DSPP | dentin sialophosphoprotein | -0.0185256 |
| CEP350 | centrosomal protein 350kDa | -0.0182781 |
| SH3D19 | SH3 domain containing 19 | -0.0181916 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0181642 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0180936 |
| TUT4 | terminal uridylyl transferase 4 | -0.0180724 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.018004 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0178451 |
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 | -0.0177856 |
| CCND1 | cyclin D1 | -0.0177381 |
| RPS19 | ribosomal protein S19 | -0.017524 |
| UBAP2 | ubiquitin associated protein 2 | -0.0174499 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0173606 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.0172996 |
| ERI2 | ERI1 exoribonuclease family member 2 | -0.0172771 |
| TUT7 | terminal uridylyl transferase 7 | -0.0170528 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0169834 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0169225 |
| CARNMT1 | carnosine N-methyltransferase 1 | -0.0168967 |
| INTS6 | integrator complex subunit 6 | -0.016893 |
| USO1 | USO1 vesicle transport factor | -0.0168803 |
| PUM3 | pumilio RNA binding family member 3 | -0.0167935 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0167555 |
