Irinotecan (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.123752
EIF1 eukaryotic translation initiation factor 1 0.0952901
KIZ kizuna centrosomal protein 0.0830847
RPS3 ribosomal protein S3 0.0825287
RPL26 ribosomal protein L26 0.0796397
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0791698
KRT8 keratin 8, type II 0.078813
PLEC plectin 0.0769736
CMIP c-Maf inducing protein 0.0760109
LMO7 LIM domain 7 0.0740011
RPS12 ribosomal protein S12 0.0703116
SRRM2 serine/arginine repetitive matrix 2 0.0681881
TNS3 tensin 3 0.067788
NAV2 neuron navigator 2 0.0619181
ZNF638 zinc finger protein 638 0.0612632
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0592783
HSPA8 heat shock 70kDa protein 8 0.057521
GARS1 glycyl-tRNA synthetase 1 0.0568357
BPTF bromodomain PHD finger transcription factor 0.0567301
TTC17 tetratricopeptide repeat domain 17 0.0551478
PRRC2C proline-rich coiled-coil 2C 0.0548023
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0546156
RPL37A ribosomal protein L37a 0.0522723
SMAD3 SMAD family member 3 0.0518403
AKAP9 A kinase (PRKA) anchor protein 9 0.0507342
TTC3 tetratricopeptide repeat domain 3 0.0503836
OGA O-GlcNAcase 0.0501124
EEF2 eukaryotic translation elongation factor 2 0.0496702
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0492882
MYH9 myosin, heavy chain 9, non-muscle 0.0489442
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0479431
RAD51B RAD51 paralog B 0.0477175
LMNA lamin A/C 0.0472636
MBNL2 muscleblind-like splicing regulator 2 0.0469701
RPL11 ribosomal protein L11 0.0466341
KRT18 keratin 18, type I 0.0465486
AARS1 alanyl-tRNA synthetase 1 0.0460829
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0460618
ANKRD11 ankyrin repeat domain 11 0.0456184
MPRIP myosin phosphatase Rho interacting protein 0.0455641
RPL9 ribosomal protein L9 0.0453942
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0443246
BCAS3 breast carcinoma amplified sequence 3 0.0437117
SETD5 SET domain containing 5 0.0431516
NEBL nebulette 0.043001
NACA nascent polypeptide-associated complex alpha subunit 0.0427331
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0421425
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0420453
MBNL1 muscleblind-like splicing regulator 1 0.0419076
ETNK1 ethanolamine kinase 1 0.0410009
THOC2 THO complex 2 0.0403859
AKAP13 A kinase (PRKA) anchor protein 13 0.0402136
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0398213
PCLO piccolo presynaptic cytomatrix protein 0.039809
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0397033
TRIO trio Rho guanine nucleotide exchange factor 0.0394311
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0388545
TBC1D22A TBC1 domain family, member 22A 0.0384359
MBD5 methyl-CpG binding domain protein 5 0.0383984
ZFAND3 zinc finger, AN1-type domain 3 0.0383268
NUMA1 nuclear mitotic apparatus protein 1 0.0380812
HELZ helicase with zinc finger 0.0377451
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0376711
SSH2 slingshot protein phosphatase 2 0.0376116
EIF4B eukaryotic translation initiation factor 4B 0.0375457
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0374352
NONO non-POU domain containing, octamer-binding 0.0371058
BRD4 bromodomain containing 4 0.0370452
ZBTB20 zinc finger and BTB domain containing 20 0.0368328
EZR ezrin 0.0366968
PTEN phosphatase and tensin homolog 0.0366603
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0364962
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0363221
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0362376
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0362146
CBX5 chromobox homolog 5 0.0361718
HP1BP3 heterochromatin protein 1, binding protein 3 0.0355937
VGLL4 vestigial-like family member 4 0.0354765
NHSL1 NHS-like 1 0.0351761
GIGYF2 GRB10 interacting GYF protein 2 0.0349936
JMJD1C jumonji domain containing 1C 0.0347986
YEATS2 YEATS domain containing 2 0.0347837
PSAT1 phosphoserine aminotransferase 1 0.0347551
RPL37 ribosomal protein L37 0.0347204
CEP128 centrosomal protein 128kDa 0.0347028
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0342986
SRSF11 serine/arginine-rich splicing factor 11 0.0336542
RBM26 RNA binding motif protein 26 0.0336058
AFDN afadin, adherens junction formation factor 0.0335832
KLF5 Kruppel-like factor 5 (intestinal) 0.0334326
IARS1 isoleucyl-tRNA synthetase 1 0.0332238
RPL7A ribosomal protein L7a 0.0326799
ARHGAP18 Rho GTPase activating protein 18 0.032566
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0325058
TARS1 threonyl-tRNA synthetase 1 0.0324997
PRELID2 PRELI domain containing 2 0.0324962
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0323509
MKI67 marker of proliferation Ki-67 0.0323354
RPL13A ribosomal protein L13a 0.0322875
GLG1 golgi glycoprotein 1 0.031918

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.147406
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.107042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104054
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0798998
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0781081
TMSB10 thymosin beta 10 -0.0611001
TMEM123 transmembrane protein 123 -0.0608041
NKD1 naked cuticle homolog 1 (Drosophila) -0.0596803
MT2A metallothionein 2A -0.0590729
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0574056
CD46 CD46 molecule, complement regulatory protein -0.055778
PTMA prothymosin, alpha -0.0549497
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0547926
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0538149
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0498013
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.049711
PDGFA platelet-derived growth factor alpha polypeptide -0.0493937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.047722
CCND1 cyclin D1 -0.0438983
AHNAK AHNAK nucleoprotein -0.0431992
FTH1 ferritin, heavy polypeptide 1 -0.0423542
NDRG1 N-myc downstream regulated 1 -0.0419819
ADGRL2 adhesion G protein-coupled receptor L2 -0.0404841
POTEF POTE ankyrin domain family, member F -0.0401962
H1-0 H1.0 linker histone -0.0400006
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0396346
VMP1 vacuole membrane protein 1 -0.0368891
PDIA3 protein disulfide isomerase family A, member 3 -0.0361146
CCNL1 cyclin L1 -0.0356909
ANKRD28 ankyrin repeat domain 28 -0.0352724
IER3 immediate early response 3 -0.0347609
CDK8 cyclin-dependent kinase 8 -0.034603
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0343856
IPO7 importin 7 -0.0335372
FHIT fragile histidine triad -0.0333952
HMGB1 high mobility group box 1 -0.0320476
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0317143
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0313197
YAP1 Yes-associated protein 1 -0.0308982
SDK1 sidekick cell adhesion molecule 1 -0.0305489
PROX1 prospero homeobox 1 -0.030314
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0298206
TPM4 tropomyosin 4 -0.0297177
FOSL1 FOS-like antigen 1 -0.0294714
ARF4 ADP-ribosylation factor 4 -0.0293623
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0291778
USP34 ubiquitin specific peptidase 34 -0.0291331
PERP PERP, TP53 apoptosis effector -0.0290791
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0286301
MT1X metallothionein 1X -0.0284769
CDCP1 CUB domain containing protein 1 -0.0280764
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0276635
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0271781
PFN1 profilin 1 -0.0266063
TUBA1B tubulin, alpha 1b -0.026413
KDM7A lysine (K)-specific demethylase 7A -0.0262698
VDAC1 voltage-dependent anion channel 1 -0.0259061
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0257103
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0256655
MRPS6 mitochondrial ribosomal protein S6 -0.0253887
MAML2 mastermind-like 2 (Drosophila) -0.0249121
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0248577
HMGA1 high mobility group AT-hook 1 -0.024835
UFM1 ubiquitin-fold modifier 1 -0.0245106
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0243019
ACTN4 actinin, alpha 4 -0.0241612
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0241043
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0239734
SDC4 syndecan 4 -0.0237119
AKAP12 A kinase (PRKA) anchor protein 12 -0.0237008
XPO7 exportin 7 -0.0233578
PPARG peroxisome proliferator-activated receptor gamma -0.0232191
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0229796
SNX9 sorting nexin 9 -0.0227731
RYBP RING1 and YY1 binding protein -0.0226998
RASA2 RAS p21 protein activator 2 -0.0226752
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0226087
FTL ferritin, light polypeptide -0.0225127
OXR1 oxidation resistance 1 -0.02249
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.021876
COG5 component of oligomeric golgi complex 5 -0.0218438
CANX calnexin -0.0217515
UGCG UDP-glucose ceramide glucosyltransferase -0.0217239
MYOF myoferlin -0.0215696
RBM39 RNA binding motif protein 39 -0.0215609
PTBP2 polypyrimidine tract binding protein 2 -0.0215586
SETX senataxin -0.0215155
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0215069
S100A10 S100 calcium binding protein A10 -0.0214583
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0213855
S100A11 S100 calcium binding protein A11 -0.0213415
TM9SF3 transmembrane 9 superfamily member 3 -0.0212691
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0212146
MARCHF7 membrane associated ring-CH-type finger 7 -0.021147
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.021126
CLTC clathrin, heavy chain (Hc) -0.0211096
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0208625
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0204276
IPO5 importin 5 -0.0201498
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0201151