| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.232882 |
| HLA-B | major histocompatibility complex, class I, B | 0.168503 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.155133 |
| B2M | beta-2-microglobulin | 0.122204 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.114412 |
| FN1 | fibronectin 1 | 0.100819 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0860049 |
| FAM13A | family with sequence similarity 13, member A | 0.084595 |
| HLA-A | major histocompatibility complex, class I, A | 0.0836451 |
| ACTG1 | actin gamma 1 | 0.0801941 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.078658 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0784783 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0760166 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0759753 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0744438 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0646067 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0605035 |
| ADM | adrenomedullin | 0.0581222 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0569718 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0566572 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0565562 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0563902 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0549742 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0540343 |
| RPS6 | ribosomal protein S6 | 0.0535219 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0529371 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0516433 |
| GOLGA4 | golgin A4 | 0.0513391 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0503258 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0494298 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0481373 |
| VEGFA | vascular endothelial growth factor A | 0.0475981 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0474909 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0470668 |
| RPS12 | ribosomal protein S12 | 0.0464134 |
| PCBP2 | poly(rC) binding protein 2 | 0.0458391 |
| FNIP1 | folliculin interacting protein 1 | 0.0454966 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0450582 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0445038 |
| STC2 | stanniocalcin 2 | 0.0443823 |
| TNS1 | tensin 1 | 0.0442967 |
| AXL | AXL receptor tyrosine kinase | 0.0440225 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0429635 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0428967 |
| SETD5 | SET domain containing 5 | 0.0420223 |
| POTEF | POTE ankyrin domain family, member F | 0.0413438 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0408197 |
| PRELID2 | PRELI domain containing 2 | 0.0406624 |
| MSN | moesin | 0.0401954 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0398605 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0390589 |
| HSPA8 | heat shock 70kDa protein 8 | 0.039045 |
| TMF1 | TATA element modulatory factor 1 | 0.0385421 |
| RPL37A | ribosomal protein L37a | 0.0379691 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0377045 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.037457 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0370146 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0364993 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0364818 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0363501 |
| FMNL2 | formin-like 2 | 0.0363113 |
| NPTX1 | neuronal pentraxin I | 0.0351018 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0348321 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0345275 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0343118 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0338848 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0329688 |
| SMYD3 | SET and MYND domain containing 3 | 0.0324282 |
| FLNA | filamin A, alpha | 0.0322657 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0322465 |
| WDR43 | WD repeat domain 43 | 0.0317906 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.031728 |
| RPL11 | ribosomal protein L11 | 0.031683 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0312744 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0309739 |
| RNF150 | ring finger protein 150 | 0.0306125 |
| PHF3 | PHD finger protein 3 | 0.0304217 |
| SEPTIN9 | septin 9 | 0.0303914 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0302035 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0301481 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0300892 |
| NBAS | neuroblastoma amplified sequence | 0.0298074 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0297663 |
| PGK1 | phosphoglycerate kinase 1 | 0.0294751 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0292047 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0291473 |
| ZNF292 | zinc finger protein 292 | 0.0291111 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0290033 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0289198 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0288549 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0287863 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0287305 |
| NOTCH2 | notch 2 | 0.0284748 |
| SON | SON DNA binding protein | 0.0281623 |
| SFTPA2 | surfactant protein A2 | 0.0281254 |
| RPL23 | ribosomal protein L23 | 0.0280602 |
| DST | dystonin | 0.0280421 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0277223 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0277049 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0276607 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.332316 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.167045 |
| INHBA | inhibin, beta A | -0.115928 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.112633 |
| HMGA2 | high mobility group AT-hook 2 | -0.0896133 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0821893 |
| IER3 | immediate early response 3 | -0.0788024 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0733227 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0717333 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0710566 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0706397 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0677408 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0611216 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0575451 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0541712 |
| CD44 | CD44 molecule (Indian blood group) | -0.0534635 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0523982 |
| OXR1 | oxidation resistance 1 | -0.0515863 |
| STC1 | stanniocalcin 1 | -0.0510035 |
| FTL | ferritin, light polypeptide | -0.0498722 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0476602 |
| EMP1 | epithelial membrane protein 1 | -0.0449479 |
| MT2A | metallothionein 2A | -0.0405161 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0357221 |
| COL1A1 | collagen, type I, alpha 1 | -0.0356214 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0348565 |
| PTMA | prothymosin, alpha | -0.0344308 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0342921 |
| RAI14 | retinoic acid induced 14 | -0.0340002 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0339159 |
| ASPH | aspartate beta-hydroxylase | -0.0338741 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0326028 |
| DIAPH2 | diaphanous-related formin 2 | -0.0306608 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0300983 |
| CANX | calnexin | -0.0298818 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0285709 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0282201 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0280701 |
| CCDC102B | coiled-coil domain containing 102B | -0.027825 |
| OSMR | oncostatin M receptor | -0.0260485 |
| ARF1 | ADP-ribosylation factor 1 | -0.0258612 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0252537 |
| RPS24 | ribosomal protein S24 | -0.02521 |
| RYBP | RING1 and YY1 binding protein | -0.0250048 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0249534 |
| WTAP | Wilms tumor 1 associated protein | -0.0247285 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0242606 |
| FRMD4A | FERM domain containing 4A | -0.0242126 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0239342 |
| CALR | calreticulin | -0.0233534 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0232263 |
| QKI | QKI, KH domain containing, RNA binding | -0.0230323 |
| COL5A2 | collagen, type V, alpha 2 | -0.0229312 |
| HMGB1 | high mobility group box 1 | -0.0228521 |
| PLPP3 | phospholipid phosphatase 3 | -0.022596 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0224553 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0219495 |
| RIGI | RNA sensor RIG-I | -0.0217205 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0215611 |
| IL6 | interleukin 6 | -0.0212328 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0201558 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0201454 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0201298 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0199331 |
| ITGA1 | integrin, alpha 1 | -0.019898 |
| H1-0 | H1.0 linker histone | -0.01965 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0194106 |
| CCND1 | cyclin D1 | -0.0192025 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.01915 |
| SRP72 | signal recognition particle 72kDa | -0.0190455 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0189507 |
| SNX9 | sorting nexin 9 | -0.0182234 |
| SMAD2 | SMAD family member 2 | -0.0179766 |
| INTS6 | integrator complex subunit 6 | -0.0179397 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0177871 |
| KLF6 | Kruppel-like factor 6 | -0.0176843 |
| SEPTIN11 | septin 11 | -0.0176131 |
| RRBP1 | ribosome binding protein 1 | -0.0174241 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0169153 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0168734 |
| MAGT1 | magnesium transporter 1 | -0.0168268 |
| CUL4B | cullin 4B | -0.0166709 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0166225 |
| CCDC47 | coiled-coil domain containing 47 | -0.0165208 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0164199 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0163272 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0162781 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0162655 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.0162484 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0161356 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0161256 |
| MYO10 | myosin X | -0.016003 |
| CD2AP | CD2-associated protein | -0.0160017 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0159717 |
| NDRG1 | N-myc downstream regulated 1 | -0.0158153 |
| PTX3 | pentraxin 3, long | -0.0157384 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0157288 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0157262 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0156798 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0155545 |
