Irinotecan_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.193098
CDH13 cadherin 13 0.152997
RUNX1 runt-related transcription factor 1 0.101322
HDAC9 histone deacetylase 9 0.100464
PBX3 pre-B-cell leukemia homeobox 3 0.100457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100308
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0975032
SLC39A11 solute carrier family 39, member 11 0.0906617
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0903584
EGFR epidermal growth factor receptor 0.0870444
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0867089
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0841906
EFNA5 ephrin-A5 0.0776934
ASPH aspartate beta-hydroxylase 0.0776741
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0760083
CENPF centromere protein F, 350/400kDa 0.0741684
MACF1 microtubule-actin crosslinking factor 1 0.0711935
DST dystonin 0.0691871
ANKRD11 ankyrin repeat domain 11 0.0679483
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0638262
TPM3 tropomyosin 3 0.0627692
MSN moesin 0.0524708
PODXL podocalyxin-like 0.052327
FNDC3B fibronectin type III domain containing 3B 0.0523009
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0516644
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0514503
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0508758
MAP1B microtubule-associated protein 1B 0.0487297
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0466313
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0466244
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0465462
FLNB filamin B, beta 0.0460929
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0432656
EXT1 exostosin glycosyltransferase 1 0.042289
NAV2 neuron navigator 2 0.0422587
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.041158
PTK2 protein tyrosine kinase 2 0.0411387
NAV1 neuron navigator 1 0.0408883
ANO6 anoctamin 6 0.0402428
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0400619
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0399265
PRELID2 PRELI domain containing 2 0.0398349
DSPP dentin sialophosphoprotein 0.039823
MYH9 myosin, heavy chain 9, non-muscle 0.039769
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0394408
ZSWIM6 zinc finger, SWIM-type containing 6 0.0393025
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0386297
SMAD3 SMAD family member 3 0.0381248
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0374081
MYOF myoferlin 0.0368447
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0367824
ADAM9 ADAM metallopeptidase domain 9 0.0367212
PRKCE protein kinase C, epsilon 0.0356714
DCLK2 doublecortin-like kinase 2 0.0355395
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0354329
DGKG diacylglycerol kinase, gamma 90kDa 0.0351975
LNPEP leucyl/cystinyl aminopeptidase 0.0351621
CEP170 centrosomal protein 170kDa 0.0351308
FNIP1 folliculin interacting protein 1 0.035111
GOLGB1 golgin B1 0.0350546
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0347467
SP100 SP100 nuclear antigen 0.0347278
JMJD1C jumonji domain containing 1C 0.0344213
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0344056
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0337283
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033603
MCL1 myeloid cell leukemia 1 0.0334367
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0333016
BACE2 beta-site APP-cleaving enzyme 2 0.0326591
PKM pyruvate kinase, muscle 0.032654
MBNL1 muscleblind-like splicing regulator 1 0.0314872
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0313942
ZNF292 zinc finger protein 292 0.0312808
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0312435
FAM219A family with sequence similarity 219, member A 0.0309612
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0309461
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0309006
CDK6 cyclin-dependent kinase 6 0.0308849
LIMCH1 LIM and calponin homology domains 1 0.0307788
DIAPH3 diaphanous-related formin 3 0.0306586
TIMP2 TIMP metallopeptidase inhibitor 2 0.0305421
RRM2 ribonucleotide reductase M2 0.0305087
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0304949
MPRIP myosin phosphatase Rho interacting protein 0.0304577
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0301925
IL6ST interleukin 6 signal transducer 0.0301404
ZNF638 zinc finger protein 638 0.0297542
SEPTIN9 septin 9 0.0296765
PICALM phosphatidylinositol binding clathrin assembly protein 0.0296622
TENM3 teneurin transmembrane protein 3 0.0296619
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0296267
SMC4 structural maintenance of chromosomes 4 0.0294175
RHOBTB3 Rho-related BTB domain containing 3 0.0293116
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.029094
HELZ helicase with zinc finger 0.0287516
ZEB1 zinc finger E-box binding homeobox 1 0.0287078
SDCCAG8 serologically defined colon cancer antigen 8 0.0284018
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0282357
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282001
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0280692

decreased expression

Symbol Name Standardized Value
LOX lysyl oxidase -0.168216
FBN1 fibrillin 1 -0.160852
IGFBP3 insulin-like growth factor binding protein 3 -0.135566
VIM vimentin -0.129815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123925
COL1A2 collagen, type I, alpha 2 -0.103156
THBS2 thrombospondin 2 -0.0922309
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0831711
COL3A1 collagen, type III, alpha 1 -0.0732927
COL5A2 collagen, type V, alpha 2 -0.071371
TMSB10 thymosin beta 10 -0.0701362
LOXL2 lysyl oxidase-like 2 -0.0578236
HLA-B major histocompatibility complex, class I, B -0.0564446
COL8A1 collagen, type VIII, alpha 1 -0.0545703
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0542079
SOD2 superoxide dismutase 2, mitochondrial -0.0497602
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0448673
FTH1 ferritin, heavy polypeptide 1 -0.0404477
MT2A metallothionein 2A -0.0393346
HLA-E major histocompatibility complex, class I, E -0.0372826
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0356211
IFITM1 interferon induced transmembrane protein 1 -0.0341606
S100A6 S100 calcium binding protein A6 -0.0327381
DPYSL3 dihydropyrimidinase-like 3 -0.0312062
UBC ubiquitin C -0.0312026
STC1 stanniocalcin 1 -0.0302498
ABI3BP ABI family, member 3 (NESH) binding protein -0.0299646
GPC6 glypican 6 -0.0296531
CAVIN1 caveolae associated protein 1 -0.0296116
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0290153
FN1 fibronectin 1 -0.0284282
MARCKS myristoylated alanine-rich protein kinase C substrate -0.028308
SUCNR1 succinate receptor 1 -0.0279561
NPR2 natriuretic peptide receptor 2 -0.0275519
LOC112694756 uncharaterized LOC112694756 -0.0271687
HLA-C major histocompatibility complex, class I, C -0.0266558
PSD3 pleckstrin and Sec7 domain containing 3 -0.0260115
MEIS2 Meis homeobox 2 -0.0258333
BSG basigin (Ok blood group) -0.0249377
TUBB tubulin, beta class I -0.0247122
GOLGA2 golgin A2 -0.0246394
MYADM myeloid-associated differentiation marker -0.0242457
S100A4 S100 calcium binding protein A4 -0.0236085
TMOD1 tropomodulin 1 -0.0235419
ARL15 ADP-ribosylation factor-like 15 -0.023531
LMNA lamin A/C -0.0227927
ARL4C ADP-ribosylation factor-like 4C -0.020407
PXDN peroxidasin -0.0200939
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0199128
IFITM3 interferon induced transmembrane protein 3 -0.019766
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.019653
KIFAP3 kinesin-associated protein 3 -0.0189769
WDFY1 WD repeat and FYVE domain containing 1 -0.018637
WARS1 tryptophanyl-tRNA synthetase 1 -0.0185944
COL6A1 collagen, type VI, alpha 1 -0.0178713
RRBP1 ribosome binding protein 1 -0.0178105
CTSB cathepsin B -0.0177815
CCL5 chemokine (C-C motif) ligand 5 -0.0177603
PRRX1 paired related homeobox 1 -0.0172802
HDLBP high density lipoprotein binding protein -0.017229
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0171734
COL6A2 collagen, type VI, alpha 2 -0.0169118
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0166372
LY6E lymphocyte antigen 6 complex, locus E -0.0165878
ZBTB20 zinc finger and BTB domain containing 20 -0.0164011
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0162238
LMAN1 lectin, mannose-binding, 1 -0.0161208
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0149531
ANKRD10 ankyrin repeat domain 10 -0.0146494
CLU clusterin -0.0144617
ANXA2 annexin A2 -0.014447
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0143173
EIF1 eukaryotic translation initiation factor 1 -0.0143149
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0142599
ARF1 ADP-ribosylation factor 1 -0.0142216
TM4SF1 transmembrane 4 L six family member 1 -0.0139423
HSPB1 heat shock 27kDa protein 1 -0.0134642
NDFIP1 Nedd4 family interacting protein 1 -0.013432
FTL ferritin, light polypeptide -0.0133601
ACTG1 actin gamma 1 -0.0131658
SCAMP1 secretory carrier membrane protein 1 -0.0129358
LAMP1 lysosomal-associated membrane protein 1 -0.0129012
S100A11 S100 calcium binding protein A11 -0.012859
FRMD5 FERM domain containing 5 -0.0128349
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0128233
NAP1L1 nucleosome assembly protein 1-like 1 -0.0126473
SH3BP2 SH3-domain binding protein 2 -0.0125376
MXRA5 matrix-remodelling associated 5 -0.0123837
MT1X metallothionein 1X -0.0122793
CKAP4 cytoskeleton-associated protein 4 -0.0122285
NEFL neurofilament, light polypeptide -0.0120841
GARS1 glycyl-tRNA synthetase 1 -0.0120621
HLA-A major histocompatibility complex, class I, A -0.0120452
IGFBP6 insulin-like growth factor binding protein 6 -0.011982
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0119395
SLC38A1 solute carrier family 38, member 1 -0.0118888
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0118809
PFKL phosphofructokinase, liver -0.011766
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0117614
MTSS1 metastasis suppressor 1 -0.0117142