| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.207491 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.145235 |
| NLGN1 | neuroligin 1 | 0.128168 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.124509 |
| YAP1 | Yes-associated protein 1 | 0.121122 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.112705 |
| HMGA2 | high mobility group AT-hook 2 | 0.102168 |
| RRM2 | ribonucleotide reductase M2 | 0.101904 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0835006 |
| WWOX | WW domain containing oxidoreductase | 0.0761623 |
| PCDH7 | protocadherin 7 | 0.0756888 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0725534 |
| VMP1 | vacuole membrane protein 1 | 0.0717009 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.070847 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0705341 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0668668 |
| RPS6 | ribosomal protein S6 | 0.0654027 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0652581 |
| TPM3 | tropomyosin 3 | 0.0640206 |
| RPS12 | ribosomal protein S12 | 0.0638527 |
| TMSB10 | thymosin beta 10 | 0.0607546 |
| ASPH | aspartate beta-hydroxylase | 0.0597573 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0586165 |
| JMJD1C | jumonji domain containing 1C | 0.0567957 |
| TENM3 | teneurin transmembrane protein 3 | 0.0558128 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0557141 |
| ADIPOR2 | adiponectin receptor 2 | 0.0546467 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0544225 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0529859 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0528408 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0523154 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0520393 |
| ZNF638 | zinc finger protein 638 | 0.0513093 |
| NEGR1 | neuronal growth regulator 1 | 0.0512026 |
| PRELID2 | PRELI domain containing 2 | 0.0507065 |
| IPO7 | importin 7 | 0.0499016 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.049634 |
| FTL | ferritin, light polypeptide | 0.0490215 |
| TPI1 | triosephosphate isomerase 1 | 0.0488181 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0476016 |
| HELLS | helicase, lymphoid-specific | 0.0463415 |
| PCDH9 | protocadherin 9 | 0.0445801 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.044344 |
| HSPA8 | heat shock 70kDa protein 8 | 0.04414 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0440601 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0437445 |
| EPHA6 | EPH receptor A6 | 0.0436222 |
| RAD51B | RAD51 paralog B | 0.0432764 |
| BRD2 | bromodomain containing 2 | 0.0430232 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.042981 |
| GOLGB1 | golgin B1 | 0.042928 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.042876 |
| PCBP2 | poly(rC) binding protein 2 | 0.0428645 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0426858 |
| NHSL1 | NHS-like 1 | 0.042319 |
| INTS6 | integrator complex subunit 6 | 0.0421015 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0417029 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0414068 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.040939 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0408981 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0408396 |
| RPS19 | ribosomal protein S19 | 0.0408305 |
| PDGFC | platelet derived growth factor C | 0.0402045 |
| MED13L | mediator complex subunit 13-like | 0.0398952 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0398677 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0397064 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0392205 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0388453 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0384787 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0384739 |
| PTMA | prothymosin, alpha | 0.0383498 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0377873 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0372605 |
| HDAC9 | histone deacetylase 9 | 0.0370218 |
| DIAPH3 | diaphanous-related formin 3 | 0.0368575 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0368526 |
| RPS8 | ribosomal protein S8 | 0.036634 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0365955 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0362336 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0358682 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0356096 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0351759 |
| MSH2 | mutS homolog 2 | 0.0351292 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0349652 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.034922 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0345099 |
| FUS | FUS RNA binding protein | 0.0343148 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.034054 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0338591 |
| NEBL | nebulette | 0.0331931 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0330614 |
| FHIT | fragile histidine triad | 0.0330093 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0329635 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0328083 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0326161 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0320793 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0320043 |
| SMYD3 | SET and MYND domain containing 3 | 0.0317297 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0315596 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0315281 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0458499 |
| LMO7 | LIM domain 7 | -0.042917 |
| VIM | vimentin | -0.0416909 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0408361 |
| CLDN1 | claudin 1 | -0.040523 |
| MMP12 | matrix metallopeptidase 12 | -0.039451 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0393365 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0382946 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0375257 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0341059 |
| KIF5B | kinesin family member 5B | -0.0323687 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0319778 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0305527 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0300027 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0293577 |
| H1-0 | H1.0 linker histone | -0.0291712 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.028187 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0269497 |
| KLF6 | Kruppel-like factor 6 | -0.026651 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0265676 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0260828 |
| TMEM123 | transmembrane protein 123 | -0.0254184 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.02409 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0229422 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0226612 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0226489 |
| WDR43 | WD repeat domain 43 | -0.0221578 |
| ANXA1 | annexin A1 | -0.0214562 |
| ZNF217 | zinc finger protein 217 | -0.0213374 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0213166 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0208151 |
| PGK1 | phosphoglycerate kinase 1 | -0.0208027 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0204394 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0202025 |
| KLHL24 | kelch-like family member 24 | -0.0201439 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0198011 |
| CDK17 | cyclin-dependent kinase 17 | -0.0197257 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0191256 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0187857 |
| WDR45B | WD repeat domain 45B | -0.0187414 |
| CENPE | centromere protein E, 312kDa | -0.0181341 |
| BCHE | butyrylcholinesterase | -0.0176684 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0176484 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0176042 |
| CCNG1 | cyclin G1 | -0.0174876 |
| CENPF | centromere protein F, 350/400kDa | -0.0172944 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0172155 |
| THOC2 | THO complex 2 | -0.0170697 |
| GASK1B | golgi associated kinase 1B | -0.0169688 |
| PRR11 | proline rich 11 | -0.0167934 |
| AHNAK | AHNAK nucleoprotein | -0.0166731 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0165543 |
| NABP1 | nucleic acid binding protein 1 | -0.0163567 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0161641 |
| HMGA1 | high mobility group AT-hook 1 | -0.0160684 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0159201 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0158803 |
| ACTG1 | actin gamma 1 | -0.015824 |
| S100A6 | S100 calcium binding protein A6 | -0.0158047 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0156539 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0156305 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0155238 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0153047 |
| TMEM131 | transmembrane protein 131 | -0.0151734 |
| WASF2 | WAS protein family, member 2 | -0.0151271 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.014894 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0147213 |
| SLC38A1 | solute carrier family 38, member 1 | -0.014687 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0146277 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0143449 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0143093 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0142425 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0142307 |
| RPS24 | ribosomal protein S24 | -0.0142233 |
| RPL6 | ribosomal protein L6 | -0.0141517 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.0140809 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0139325 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0139125 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0137334 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0134944 |
| GM2A | GM2 ganglioside activator | -0.0133542 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.013296 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0132334 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0130769 |
| FOXK2 | forkhead box K2 | -0.0130394 |
| TXNRD1 | thioredoxin reductase 1 | -0.0128478 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0127354 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0127342 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.012718 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0125225 |
| URI1 | URI1, prefoldin-like chaperone | -0.0124346 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0122484 |
| IPMK | inositol polyphosphate multikinase | -0.0122258 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0122031 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0121564 |
| NEK7 | NIMA-related kinase 7 | -0.0120139 |
| ZFP64 | ZFP64 zinc finger protein | -0.0119679 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.0119398 |
| EDN1 | endothelin 1 | -0.0119063 |
| TUBB | tubulin, beta class I | -0.0117769 |
