| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.19109 |
| TLE4 | transducin-like enhancer of split 4 | 0.10591 |
| FMN1 | formin 1 | 0.0892469 |
| MEIS2 | Meis homeobox 2 | 0.0862397 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0849281 |
| VMP1 | vacuole membrane protein 1 | 0.0723852 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0702589 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0654286 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0619528 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0501908 |
| DPH6 | diphthamine biosynthesis 6 | 0.0488928 |
| STK38L | serine/threonine kinase 38 like | 0.045489 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0448045 |
| INTS6 | integrator complex subunit 6 | 0.0440531 |
| RNF213 | ring finger protein 213 | 0.0438637 |
| RIGI | RNA sensor RIG-I | 0.04238 |
| KLHL13 | kelch-like family member 13 | 0.0418886 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0394448 |
| FERMT2 | fermitin family member 2 | 0.0383022 |
| FAM107B | family with sequence similarity 107, member B | 0.0370679 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0369614 |
| MYO1E | myosin IE | 0.0365065 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0364016 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347056 |
| MAPK10 | mitogen-activated protein kinase 10 | 0.0345883 |
| PLPP1 | phospholipid phosphatase 1 | 0.0345297 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0344712 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.033367 |
| GLCCI1 | glucocorticoid induced 1 | 0.033342 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.033224 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0326684 |
| ATXN1 | ataxin 1 | 0.0322991 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0319329 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0318685 |
| SMYD3 | SET and MYND domain containing 3 | 0.0314075 |
| AUTS2 | autism susceptibility candidate 2 | 0.0307372 |
| LIMA1 | LIM domain and actin binding 1 | 0.0299049 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0289273 |
| FHIT | fragile histidine triad | 0.0288526 |
| MX2 | MX dynamin-like GTPase 2 | 0.028738 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0286896 |
| TPM1 | tropomyosin 1 (alpha) | 0.0283448 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0278708 |
| HOMER1 | homer scaffolding protein 1 | 0.0275841 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0272618 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0271924 |
| NPAS2 | neuronal PAS domain protein 2 | 0.027048 |
| RAD51B | RAD51 paralog B | 0.0269302 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0268197 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0266433 |
| KCNT2 | potassium channel, sodium activated subfamily T, member 2 | 0.0266228 |
| SIK2 | salt-inducible kinase 2 | 0.0266169 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0260034 |
| NRG1 | neuregulin 1 | 0.025845 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0253394 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0252559 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0249572 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0248308 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0246466 |
| PLAT | plasminogen activator, tissue | 0.0246109 |
| SETBP1 | SET binding protein 1 | 0.0237846 |
| PCDH17 | protocadherin 17 | 0.0234523 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0231791 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0231693 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0228222 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0225948 |
| RET | ret proto-oncogene | 0.0225486 |
| TENM1 | teneurin transmembrane protein 1 | 0.0220557 |
| AEBP2 | AE binding protein 2 | 0.0220056 |
| BPTF | bromodomain PHD finger transcription factor | 0.0215756 |
| SDC2 | syndecan 2 | 0.0213268 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.02124 |
| EXOC4 | exocyst complex component 4 | 0.0211196 |
| DST | dystonin | 0.0208544 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.020842 |
| CCNY | cyclin Y | 0.0204573 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0203368 |
| TENM4 | teneurin transmembrane protein 4 | 0.0203214 |
| CCDC57 | coiled-coil domain containing 57 | 0.0202346 |
| PLSCR1 | phospholipid scramblase 1 | 0.0200768 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.019964 |
| ANO6 | anoctamin 6 | 0.0199109 |
| FHL2 | four and a half LIM domains 2 | 0.0199095 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0198238 |
| FNBP1 | formin binding protein 1 | 0.0197898 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0197858 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0197193 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0196068 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.019382 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.019318 |
| HMGA2 | high mobility group AT-hook 2 | 0.0192882 |
| STXBP4 | syntaxin binding protein 4 | 0.0192494 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0192345 |
| VEGFA | vascular endothelial growth factor A | 0.0192155 |
| SP100 | SP100 nuclear antigen | 0.0191796 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0191485 |
| DNM3 | dynamin 3 | 0.0191428 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0191007 |
| USP34 | ubiquitin specific peptidase 34 | 0.0190249 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0189806 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.443134 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.226029 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.146749 |
| VIM | vimentin | -0.132549 |
| PTMA | prothymosin, alpha | -0.100546 |
| COL1A1 | collagen, type I, alpha 1 | -0.0910576 |
| COL3A1 | collagen, type III, alpha 1 | -0.0859024 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0625247 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0608914 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0563174 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0513624 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0495997 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0491866 |
| PKM | pyruvate kinase, muscle | -0.0422345 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0411198 |
| MAP1B | microtubule-associated protein 1B | -0.040294 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0388689 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0379793 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.037297 |
| ACTG1 | actin gamma 1 | -0.0368041 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0363114 |
| SPAG9 | sperm associated antigen 9 | -0.0362716 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0362422 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0356794 |
| RPS24 | ribosomal protein S24 | -0.0355546 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0343569 |
| WDR45B | WD repeat domain 45B | -0.033848 |
| RPL23 | ribosomal protein L23 | -0.0334194 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0327755 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.032398 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0323967 |
| RPS3 | ribosomal protein S3 | -0.0322017 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0318406 |
| CADM1 | cell adhesion molecule 1 | -0.0315636 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0315166 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0314482 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0306166 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0305142 |
| LSAMP | limbic system-associated membrane protein | -0.0302571 |
| CCND1 | cyclin D1 | -0.0301159 |
| OGA | O-GlcNAcase | -0.0300006 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0299215 |
| S100A6 | S100 calcium binding protein A6 | -0.0294094 |
| CANX | calnexin | -0.0290471 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0288037 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0286976 |
| RPL38 | ribosomal protein L38 | -0.0285917 |
| RPL19 | ribosomal protein L19 | -0.0282782 |
| GNAS | GNAS complex locus | -0.0281902 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0279921 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0278567 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0278236 |
| LMNA | lamin A/C | -0.0277509 |
| TMSB10 | thymosin beta 10 | -0.027025 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0270049 |
| HMGB2 | high mobility group box 2 | -0.0269194 |
| FOXK2 | forkhead box K2 | -0.0266369 |
| H3-3B | H3.3 histone B | -0.0266339 |
| USP36 | ubiquitin specific peptidase 36 | -0.0266264 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0264011 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.026371 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0261133 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0261042 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0260794 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0259441 |
| H1-0 | H1.0 linker histone | -0.0251162 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0248006 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0247622 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0247522 |
| NPR2 | natriuretic peptide receptor 2 | -0.0242991 |
| CLINT1 | clathrin interactor 1 | -0.024128 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0241249 |
| CLTC | clathrin, heavy chain (Hc) | -0.0241031 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0239998 |
| SEC24D | SEC24 family member D | -0.0238048 |
| CEP350 | centrosomal protein 350kDa | -0.0237663 |
| KLF6 | Kruppel-like factor 6 | -0.0237476 |
| SSH2 | slingshot protein phosphatase 2 | -0.0234725 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0233767 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0233231 |
| ANXA2 | annexin A2 | -0.0231861 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0229078 |
| PCDH9 | protocadherin 9 | -0.0229032 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0227478 |
| SRP72 | signal recognition particle 72kDa | -0.0226416 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0226338 |
| ATP13A3 | ATPase type 13A3 | -0.022505 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0225016 |
| NDRG1 | N-myc downstream regulated 1 | -0.022471 |
| PTK2 | protein tyrosine kinase 2 | -0.0223406 |
| AOPEP | aminopeptidase O (putative) | -0.0220866 |
| IER3 | immediate early response 3 | -0.0220164 |
| NEK7 | NIMA-related kinase 7 | -0.0216776 |
| CDC27 | cell division cycle 27 | -0.0216705 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0215802 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0215255 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0215248 |
| TMEM123 | transmembrane protein 123 | -0.0214897 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0214181 |
| CCDC47 | coiled-coil domain containing 47 | -0.0212443 |
