| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.360945 |
| INTS6 | integrator complex subunit 6 | 0.156793 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.146453 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.132001 |
| SMAD3 | SMAD family member 3 | 0.105146 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0945517 |
| ANXA2 | annexin A2 | 0.0943646 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.086481 |
| EFNB2 | ephrin-B2 | 0.0824347 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0823455 |
| PLSCR2 | phospholipid scramblase 2 | 0.0788944 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0764134 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0741549 |
| MYO1E | myosin IE | 0.0714982 |
| AREG | amphiregulin | 0.0666922 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0655453 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0654358 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0652511 |
| KYNU | kynureninase | 0.0605116 |
| MCU | mitochondrial calcium uniporter | 0.0604016 |
| LCN2 | lipocalin 2 | 0.0584111 |
| DST | dystonin | 0.0567777 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0552782 |
| TOX3 | TOX high mobility group box family member 3 | 0.0544601 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0541931 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0536643 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0515992 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0509415 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0490201 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0459678 |
| ERBIN | erbb2 interacting protein | 0.0434617 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0431305 |
| TJP1 | tight junction protein 1 | 0.0421525 |
| DIAPH1 | diaphanous-related formin 1 | 0.0396056 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0391044 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.038618 |
| FNIP2 | folliculin interacting protein 2 | 0.0381555 |
| MYO5B | myosin VB | 0.0371289 |
| SP100 | SP100 nuclear antigen | 0.0361548 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0357476 |
| PDZD8 | PDZ domain containing 8 | 0.035468 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0349 |
| CTBP2 | C-terminal binding protein 2 | 0.0346565 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0344785 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0338977 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0329746 |
| SIK3 | SIK family kinase 3 | 0.032551 |
| RBM47 | RNA binding motif protein 47 | 0.0325463 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0324148 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0320187 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0318333 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0315599 |
| TMEM65 | transmembrane protein 65 | 0.0314751 |
| MCL1 | myeloid cell leukemia 1 | 0.0313589 |
| VCL | vinculin | 0.0312951 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0311172 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0308009 |
| ETV6 | ets variant 6 | 0.0307987 |
| NABP1 | nucleic acid binding protein 1 | 0.0306042 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0303575 |
| YAP1 | Yes-associated protein 1 | 0.0302645 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0301118 |
| BCL2L1 | BCL2-like 1 | 0.0301058 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0299039 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0292593 |
| ASPH | aspartate beta-hydroxylase | 0.0288557 |
| VMP1 | vacuole membrane protein 1 | 0.0287494 |
| RPS6 | ribosomal protein S6 | 0.0282629 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0282438 |
| UBAP2 | ubiquitin associated protein 2 | 0.0281398 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0275753 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.027197 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0271201 |
| PERP | PERP, TP53 apoptosis effector | 0.0264308 |
| ATP11A | ATPase, class VI, type 11A | 0.0256623 |
| MSI2 | musashi RNA-binding protein 2 | 0.0255999 |
| HKDC1 | hexokinase domain containing 1 | 0.025257 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0252357 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0248921 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0248436 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0246283 |
| POF1B | premature ovarian failure, 1B | 0.0242121 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0241109 |
| RPS12 | ribosomal protein S12 | 0.0240693 |
| SDCBP | syndecan binding protein (syntenin) | 0.0240289 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0239452 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0239141 |
| SLK | STE20-like kinase | 0.0235323 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0233386 |
| MAP7 | microtubule-associated protein 7 | 0.0230813 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0225424 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.022327 |
| PRSS22 | protease, serine, 22 | 0.0220822 |
| TSC22D1 | TSC22 domain family, member 1 | 0.022043 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0219069 |
| LAMB3 | laminin, beta 3 | 0.0218927 |
| DUSP16 | dual specificity phosphatase 16 | 0.0217816 |
| SDC4 | syndecan 4 | 0.0216695 |
| ACTG1 | actin gamma 1 | 0.0215298 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0215172 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.157077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143986 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.136369 |
| H1-0 | H1.0 linker histone | -0.0945097 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0936519 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0721983 |
| TXNIP | thioredoxin interacting protein | -0.0666232 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0653229 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0632699 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0614964 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0606465 |
| RNF149 | ring finger protein 149 | -0.055943 |
| CANX | calnexin | -0.0534647 |
| NDRG1 | N-myc downstream regulated 1 | -0.0528173 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0521623 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0520216 |
| SPATA13 | spermatogenesis associated 13 | -0.048857 |
| HLA-B | major histocompatibility complex, class I, B | -0.0488187 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0470701 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0467774 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0467171 |
| PGK1 | phosphoglycerate kinase 1 | -0.0442159 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0414201 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0406293 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0404347 |
| PTMA | prothymosin, alpha | -0.0404159 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0400329 |
| PTEN | phosphatase and tensin homolog | -0.0398833 |
| LYZ | lysozyme | -0.0389468 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.038439 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0377622 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0374045 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0373265 |
| RNF43 | ring finger protein 43 | -0.037154 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0365511 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0364248 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0364113 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0363105 |
| NCKAP5 | NCK-associated protein 5 | -0.036106 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0359715 |
| ABHD2 | abhydrolase domain containing 2 | -0.0359609 |
| WDR45B | WD repeat domain 45B | -0.0356768 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0348739 |
| PTGR1 | prostaglandin reductase 1 | -0.0347508 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0346838 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0345752 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341818 |
| HDLBP | high density lipoprotein binding protein | -0.0339643 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0338841 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0337288 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0334301 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0332416 |
| RBM39 | RNA binding motif protein 39 | -0.0331032 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0325595 |
| SBF2 | SET binding factor 2 | -0.0324133 |
| AHNAK | AHNAK nucleoprotein | -0.0322703 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0322452 |
| TMEM62 | transmembrane protein 62 | -0.0314258 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0313729 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0312654 |
| DENND4C | DENN/MADD domain containing 4C | -0.0312233 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0311875 |
| MKI67 | marker of proliferation Ki-67 | -0.030965 |
| ABLIM1 | actin binding LIM protein 1 | -0.0303177 |
| CALR | calreticulin | -0.0303089 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0302486 |
| PRELID2 | PRELI domain containing 2 | -0.0302267 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.030087 |
| HLA-E | major histocompatibility complex, class I, E | -0.0293182 |
| EPHB2 | EPH receptor B2 | -0.0292114 |
| RRBP1 | ribosome binding protein 1 | -0.0291413 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0288247 |
| CMIP | c-Maf inducing protein | -0.0285673 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0285451 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0285073 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0283827 |
| TPM4 | tropomyosin 4 | -0.0283596 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0283339 |
| MUC20 | mucin 20, cell surface associated | -0.0283228 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.028218 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0280824 |
| KLF6 | Kruppel-like factor 6 | -0.0280275 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0280114 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -0.0278269 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0276499 |
| SEC24D | SEC24 family member D | -0.0276348 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0274989 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0273357 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0273219 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.0270352 |
| WASF2 | WAS protein family, member 2 | -0.0269684 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0265898 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.026549 |
| XAF1 | XIAP associated factor 1 | -0.02654 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0263462 |
| BRCA2 | breast cancer 2, early onset | -0.0263333 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0262171 |
| SSH2 | slingshot protein phosphatase 2 | -0.0261081 |
| USP3 | ubiquitin specific peptidase 3 | -0.0257885 |
| COG6 | component of oligomeric golgi complex 6 | -0.0255325 |
