Irinotecan_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.160622
NDRG1 N-myc downstream regulated 1 0.122684
CD44 CD44 molecule (Indian blood group) 0.0976408
FNDC3B fibronectin type III domain containing 3B 0.0939736
ASPH aspartate beta-hydroxylase 0.0871549
VEGFA vascular endothelial growth factor A 0.085531
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.07597
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0737741
EXT1 exostosin glycosyltransferase 1 0.0727993
CDH13 cadherin 13 0.0699119
TRIO trio Rho guanine nucleotide exchange factor 0.0681256
COL6A3 collagen, type VI, alpha 3 0.0678754
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0647095
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0644894
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0599001
GOLGB1 golgin B1 0.0552167
RUNX1 runt-related transcription factor 1 0.0508609
CXCL8 chemokine (C-X-C motif) ligand 8 0.0503527
MYH9 myosin, heavy chain 9, non-muscle 0.046435
MYO10 myosin X 0.0462809
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0449901
ZSWIM6 zinc finger, SWIM-type containing 6 0.0431887
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0418427
ATXN1 ataxin 1 0.0410184
HDAC9 histone deacetylase 9 0.0405299
SOD2 superoxide dismutase 2, mitochondrial 0.0404693
ZBTB38 zinc finger and BTB domain containing 38 0.0404264
GLIS3 GLIS family zinc finger 3 0.0400109
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0390186
PTK2 protein tyrosine kinase 2 0.0381146
ANO6 anoctamin 6 0.0380836
IL6ST interleukin 6 signal transducer 0.0375695
NAV1 neuron navigator 1 0.0372187
ALCAM activated leukocyte cell adhesion molecule 0.036534
EGFR epidermal growth factor receptor 0.0350584
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0336883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0326826
MACF1 microtubule-actin crosslinking factor 1 0.0320701
WWTR1 WW domain containing transcription regulator 1 0.0320278
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0319887
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0319699
ARRDC3 arrestin domain containing 3 0.0314387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0312686
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311675
HSPA8 heat shock 70kDa protein 8 0.0308203
AHNAK AHNAK nucleoprotein 0.0303421
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0293207
NAV2 neuron navigator 2 0.0290467
LPP LIM domain containing preferred translocation partner in lipoma 0.0287153
PSD3 pleckstrin and Sec7 domain containing 3 0.0285534
FER fer (fps/fes related) tyrosine kinase 0.0282425
SMAD3 SMAD family member 3 0.0273306
PTPRM protein tyrosine phosphatase, receptor type, M 0.0273154
DST dystonin 0.0271074
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0269074
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0267884
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.026554
SDC2 syndecan 2 0.0264589
FBXL7 F-box and leucine-rich repeat protein 7 0.0262723
PICALM phosphatidylinositol binding clathrin assembly protein 0.02607
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0259021
APP amyloid beta (A4) precursor protein 0.0257253
MTSS1 metastasis suppressor 1 0.024838
MLF1 myeloid leukemia factor 1 0.0248206
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0244747
PRELID2 PRELI domain containing 2 0.0243778
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0242161
ADAM12 ADAM metallopeptidase domain 12 0.0234895
NALF1 NALCN channel auxiliary factor 1 0.0234684
SQSTM1 sequestosome 1 0.0233029
FNIP1 folliculin interacting protein 1 0.023257
LDHA lactate dehydrogenase A 0.0232339
SHB Src homology 2 domain containing adaptor protein B 0.0232093
ZBTB20 zinc finger and BTB domain containing 20 0.0230573
FAT1 FAT atypical cadherin 1 0.0228684
SLC22A23 solute carrier family 22, member 23 0.022852
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0228167
ERRFI1 ERBB receptor feedback inhibitor 1 0.022769
FAM107B family with sequence similarity 107, member B 0.0227643
EFNA5 ephrin-A5 0.022095
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0219472
VMP1 vacuole membrane protein 1 0.0218509
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0215644
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0214906
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0213236
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0211786
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0211603
EXOC4 exocyst complex component 4 0.0210607
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0207503
MSN moesin 0.020718
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0207107
CNTN5 contactin 5 0.0200365
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0199529
SETBP1 SET binding protein 1 0.0198957
SFTPA2 surfactant protein A2 0.0193821
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0193162
BRD2 bromodomain containing 2 0.0192561
RND3 Rho family GTPase 3 0.0186839
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0185094
INTS6 integrator complex subunit 6 0.0184509

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.133094
COL1A1 collagen, type I, alpha 1 -0.130261
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.128597
TIMP3 TIMP metallopeptidase inhibitor 3 -0.127575
VIM vimentin -0.124593
IGFBP3 insulin-like growth factor binding protein 3 -0.106778
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0779458
COL1A2 collagen, type I, alpha 2 -0.0726535
TMSB10 thymosin beta 10 -0.0590791
TPM4 tropomyosin 4 -0.0565926
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0521836
LOX lysyl oxidase -0.0509171
ATP13A3 ATPase type 13A3 -0.0460953
LMAN1 lectin, mannose-binding, 1 -0.0394201
FTL ferritin, light polypeptide -0.0359507
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0358035
CAVIN1 caveolae associated protein 1 -0.0316015
PTMA prothymosin, alpha -0.0303726
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0287869
RPL35A ribosomal protein L35a -0.0269704
GARS1 glycyl-tRNA synthetase 1 -0.0260744
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0249895
RRBP1 ribosome binding protein 1 -0.0246449
WSB1 WD repeat and SOCS box containing 1 -0.0234602
EGR1 early growth response 1 -0.0229014
ICAM1 intercellular adhesion molecule 1 -0.0228098
DPYD dihydropyrimidine dehydrogenase -0.0221425
TM4SF1 transmembrane 4 L six family member 1 -0.0219281
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0218792
CANX calnexin -0.0215056
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0214311
NPEPPS aminopeptidase puromycin sensitive -0.0214101
ACTG1 actin gamma 1 -0.0213851
STC1 stanniocalcin 1 -0.0213765
RAB6A RAB6A, member RAS oncogene family -0.0212377
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.020827
F3 coagulation factor III (thromboplastin, tissue factor) -0.0204864
WASF2 WAS protein family, member 2 -0.02012
SULF1 sulfatase 1 -0.0190346
SEPTIN7 septin 7 -0.0189643
HLA-B major histocompatibility complex, class I, B -0.0188699
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0188349
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.018691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0185356
S100A6 S100 calcium binding protein A6 -0.0184539
USP3 ubiquitin specific peptidase 3 -0.0182502
KCTD9 potassium channel tetramerization domain containing 9 -0.0181044
EHD2 EH-domain containing 2 -0.0180955
RTN4 reticulon 4 -0.0178764
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0177509
PFN1 profilin 1 -0.0176636
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0174786
VDAC1 voltage-dependent anion channel 1 -0.0171743
CALD1 caldesmon 1 -0.0171211
KPNB1 karyopherin (importin) beta 1 -0.0171001
PRRC1 proline-rich coiled-coil 1 -0.0170963
TFG TRK-fused gene -0.0169673
HMGA1 high mobility group AT-hook 1 -0.0169236
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0164419
SRSF11 serine/arginine-rich splicing factor 11 -0.0163015
POSTN periostin, osteoblast specific factor -0.0162629
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0161242
FKBP10 FK506 binding protein 10, 65 kDa -0.0160468
COL7A1 collagen, type VII, alpha 1 -0.0158837
EIF1 eukaryotic translation initiation factor 1 -0.0152844
TSC22D2 TSC22 domain family, member 2 -0.0152026
TMEM41B transmembrane protein 41B -0.0151874
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0147631
TMEM263 transmembrane protein 263 -0.014756
CYB5R3 cytochrome b5 reductase 3 -0.0145888
MRPS6 mitochondrial ribosomal protein S6 -0.0142667
QKI QKI, KH domain containing, RNA binding -0.014253
IFITM3 interferon induced transmembrane protein 3 -0.0141647
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0141248
GNAS GNAS complex locus -0.0140462
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.014033
PGK1 phosphoglycerate kinase 1 -0.0140215
FNBP4 formin binding protein 4 -0.0137744
FBN1 fibrillin 1 -0.0137733
DSTN destrin (actin depolymerizing factor) -0.0137619
SQLE squalene epoxidase -0.0135879
LAMB3 laminin, beta 3 -0.013402
BSG basigin (Ok blood group) -0.0132868
ACTN4 actinin, alpha 4 -0.013251
PXDN peroxidasin -0.0130947
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0130926
TRAM1 translocation associated membrane protein 1 -0.0129329
CCDC80 coiled-coil domain containing 80 -0.0129018
BIRC6 baculoviral IAP repeat containing 6 -0.0127913
LIMA1 LIM domain and actin binding 1 -0.0127717
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0127464
SPAG9 sperm associated antigen 9 -0.0127012
VCAN versican -0.0126351
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0124661
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0124289
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0124175
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0124141
FLNA filamin A, alpha -0.0124122
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0124086
CLINT1 clathrin interactor 1 -0.0123583