| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.212026 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.117626 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.11236 |
| SVIL | supervillin | 0.102495 |
| ASPH | aspartate beta-hydroxylase | 0.0908404 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0880845 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0825156 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0811059 |
| ATXN1 | ataxin 1 | 0.0798893 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0791087 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0790411 |
| DSPP | dentin sialophosphoprotein | 0.0633563 |
| EHBP1 | EH domain binding protein 1 | 0.0626682 |
| GPC6 | glypican 6 | 0.0616784 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0596778 |
| FAM107B | family with sequence similarity 107, member B | 0.0585312 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0579442 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0569773 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.05438 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0470902 |
| DST | dystonin | 0.0462878 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0415219 |
| FRMD5 | FERM domain containing 5 | 0.0406897 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0400222 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0387522 |
| KYNU | kynureninase | 0.0381225 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0365336 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0365033 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0353776 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0342438 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0331059 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0319889 |
| VCL | vinculin | 0.031679 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0315721 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0291603 |
| FAT1 | FAT atypical cadherin 1 | 0.0291427 |
| RAD51B | RAD51 paralog B | 0.028263 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0282255 |
| FOXP1 | forkhead box P1 | 0.0280796 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0279653 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0276806 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0275317 |
| PLXDC2 | plexin domain containing 2 | 0.027481 |
| NDRG1 | N-myc downstream regulated 1 | 0.0273803 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0255392 |
| RAI14 | retinoic acid induced 14 | 0.0251517 |
| KIAA1217 | KIAA1217 | 0.023757 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0237488 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0236854 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0233926 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0233772 |
| FN1 | fibronectin 1 | 0.0230292 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0228499 |
| RASA2 | RAS p21 protein activator 2 | 0.0225913 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0223807 |
| DTNA | dystrobrevin, alpha | 0.022353 |
| AHNAK | AHNAK nucleoprotein | 0.022091 |
| ANO6 | anoctamin 6 | 0.0215147 |
| MYO1E | myosin IE | 0.0214611 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.0214384 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0212673 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0208083 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0207723 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.020754 |
| LMO7 | LIM domain 7 | 0.0195559 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0195369 |
| CRY1 | cryptochrome circadian clock 1 | 0.0194742 |
| FLNB | filamin B, beta | 0.0194049 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0189997 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.018827 |
| ITGA6 | integrin, alpha 6 | 0.0187569 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0186753 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.018316 |
| ITGAV | integrin, alpha V | 0.0182357 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0182349 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0181275 |
| SMAD3 | SMAD family member 3 | 0.017778 |
| ARFGEF3 | ARFGEF family member 3 | 0.0177318 |
| RUNX1 | runt-related transcription factor 1 | 0.0175307 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0174894 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.017437 |
| HPCAL1 | hippocalcin-like 1 | 0.0171989 |
| SMYD3 | SET and MYND domain containing 3 | 0.0170437 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0169776 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0167384 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0166677 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0163866 |
| KALRN | kalirin, RhoGEF kinase | 0.0163376 |
| GOLGB1 | golgin B1 | 0.0163359 |
| DUSP16 | dual specificity phosphatase 16 | 0.0162534 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0162229 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0162193 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0159242 |
| TXNRD1 | thioredoxin reductase 1 | 0.0156301 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0154204 |
| PALLD | palladin, cytoskeletal associated protein | 0.015297 |
| FAM13A | family with sequence similarity 13, member A | 0.0152447 |
| KRT23 | keratin 23, type I | 0.0150709 |
| CLIC4 | chloride intracellular channel 4 | 0.0150046 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0148746 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.300451 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.159184 |
| C3 | complement component 3 | -0.148277 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.128334 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.110237 |
| APOA2 | apolipoprotein A-II | -0.0810749 |
| APOB | apolipoprotein B | -0.0748698 |
| RPS6 | ribosomal protein S6 | -0.0563466 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0540481 |
| FTL | ferritin, light polypeptide | -0.0536716 |
| RPL11 | ribosomal protein L11 | -0.0506533 |
| GPC3 | glypican 3 | -0.0474913 |
| RPS12 | ribosomal protein S12 | -0.0469836 |
| RPL37A | ribosomal protein L37a | -0.0467786 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0467091 |
| AHSG | alpha-2-HS-glycoprotein | -0.0455153 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0449652 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0444648 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0429957 |
| TF | transferrin | -0.0407998 |
| LYZ | lysozyme | -0.0398175 |
| RPS8 | ribosomal protein S8 | -0.0370528 |
| RPL35A | ribosomal protein L35a | -0.0366343 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0363679 |
| RPS3 | ribosomal protein S3 | -0.0362516 |
| APOE | apolipoprotein E | -0.0360993 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0360756 |
| CPE | carboxypeptidase E | -0.035235 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0348791 |
| RPS24 | ribosomal protein S24 | -0.0335221 |
| RPL31 | ribosomal protein L31 | -0.0332722 |
| A2M | alpha-2-macroglobulin | -0.0324038 |
| TRIM26 | tripartite motif containing 26 | -0.0322265 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321409 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.031935 |
| TMEM123 | transmembrane protein 123 | -0.0313534 |
| PCBP2 | poly(rC) binding protein 2 | -0.0299295 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0294442 |
| EGR1 | early growth response 1 | -0.029323 |
| PTCHD4 | patched domain containing 4 | -0.0291 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0289801 |
| GDF15 | growth differentiation factor 15 | -0.0285441 |
| RPS19 | ribosomal protein S19 | -0.0284803 |
| RPS29 | ribosomal protein S29 | -0.0280786 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0278748 |
| APOA1 | apolipoprotein A-I | -0.0277374 |
| PERP | PERP, TP53 apoptosis effector | -0.0276466 |
| RPS27A | ribosomal protein S27a | -0.0271305 |
| HMGA1 | high mobility group AT-hook 1 | -0.0263728 |
| RBM25 | RNA binding motif protein 25 | -0.0261871 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0260075 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0256289 |
| RPL9 | ribosomal protein L9 | -0.0253203 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0251879 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0247962 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0240647 |
| PTMA | prothymosin, alpha | -0.0238795 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0236679 |
| RPS13 | ribosomal protein S13 | -0.023517 |
| RPS25 | ribosomal protein S25 | -0.0227757 |
| RPLP0 | ribosomal protein, large, P0 | -0.0226809 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0226734 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0225567 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0225154 |
| RPS23 | ribosomal protein S23 | -0.022174 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0220167 |
| RPL26 | ribosomal protein L26 | -0.0219956 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0217191 |
| GNAS | GNAS complex locus | -0.0217185 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0216171 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0214739 |
| PEG10 | paternally expressed 10 | -0.0213071 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0211632 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0211097 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0210715 |
| KIF5B | kinesin family member 5B | -0.02078 |
| RBM39 | RNA binding motif protein 39 | -0.020675 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0203696 |
| CST3 | cystatin C | -0.0203056 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0202928 |
| SELENOP | selenoprotein P | -0.0201805 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0201439 |
| RPS21 | ribosomal protein S21 | -0.0199112 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0198249 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0197554 |
| RPL28 | ribosomal protein L28 | -0.019524 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0194917 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0193291 |
| RPLP2 | ribosomal protein, large, P2 | -0.0192805 |
| RPL12 | ribosomal protein L12 | -0.0192488 |
| CFB | complement factor B | -0.0192199 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.019209 |
| RPL23 | ribosomal protein L23 | -0.0189698 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0187492 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0186533 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0182586 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0180907 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0178315 |
| RPL37 | ribosomal protein L37 | -0.0175265 |
| CP | ceruloplasmin (ferroxidase) | -0.0173348 |
