| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.120886 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.106388 |
| CD44 | CD44 molecule (Indian blood group) | 0.105736 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0927368 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0878232 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.08661 |
| ASPH | aspartate beta-hydroxylase | 0.0653633 |
| NDRG1 | N-myc downstream regulated 1 | 0.0651657 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0618676 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0616358 |
| DIAPH3 | diaphanous-related formin 3 | 0.0573329 |
| MYOF | myoferlin | 0.0571473 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0570431 |
| DST | dystonin | 0.056138 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0546083 |
| EZR | ezrin | 0.0544761 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0536576 |
| MEF2A | myocyte enhancer factor 2A | 0.0525994 |
| ITGA6 | integrin, alpha 6 | 0.0480414 |
| PTK2 | protein tyrosine kinase 2 | 0.0465865 |
| DOK5 | docking protein 5 | 0.0461304 |
| MSN | moesin | 0.0440871 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0431917 |
| POTEF | POTE ankyrin domain family, member F | 0.041549 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0410561 |
| MKI67 | marker of proliferation Ki-67 | 0.0407923 |
| ANXA1 | annexin A1 | 0.0405397 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0404808 |
| NRG1 | neuregulin 1 | 0.040349 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0403063 |
| JMJD1C | jumonji domain containing 1C | 0.039672 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0395829 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0395483 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0381841 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0376133 |
| TGM2 | transglutaminase 2 | 0.037578 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0374377 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0365514 |
| BARX2 | BARX homeobox 2 | 0.0355447 |
| TXNIP | thioredoxin interacting protein | 0.0342884 |
| FNIP1 | folliculin interacting protein 1 | 0.0320038 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0314502 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0313233 |
| AOPEP | aminopeptidase O (putative) | 0.0311947 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0306298 |
| SMYD3 | SET and MYND domain containing 3 | 0.0303881 |
| ARRDC3 | arrestin domain containing 3 | 0.030094 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0298913 |
| TPX2 | TPX2, microtubule-associated | 0.029858 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0298169 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0298056 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0295405 |
| PDS5B | PDS5 cohesin associated factor B | 0.0287877 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0287409 |
| HELLS | helicase, lymphoid-specific | 0.0286584 |
| SIK3 | SIK family kinase 3 | 0.0281465 |
| ANO6 | anoctamin 6 | 0.0280889 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0278125 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0277058 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0273487 |
| FAM107B | family with sequence similarity 107, member B | 0.0272206 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0269269 |
| CMIP | c-Maf inducing protein | 0.0268406 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.026746 |
| ZNF292 | zinc finger protein 292 | 0.0265712 |
| EXOC4 | exocyst complex component 4 | 0.0265209 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0264808 |
| KIF16B | kinesin family member 16B | 0.0264775 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0264549 |
| FRMD6 | FERM domain containing 6 | 0.0263616 |
| SMAD3 | SMAD family member 3 | 0.0263277 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0258848 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0256827 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0253761 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0252921 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0250102 |
| CEP170 | centrosomal protein 170kDa | 0.0249438 |
| PTEN | phosphatase and tensin homolog | 0.0249374 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0248746 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0242272 |
| SETD5 | SET domain containing 5 | 0.0240855 |
| CENPF | centromere protein F, 350/400kDa | 0.0237325 |
| XPO1 | exportin 1 | 0.0236317 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0235506 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0231897 |
| PRELID2 | PRELI domain containing 2 | 0.023097 |
| TXNRD1 | thioredoxin reductase 1 | 0.0230053 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.022949 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0229377 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0226887 |
| SLTM | SAFB-like, transcription modulator | 0.02258 |
| ATXN1 | ataxin 1 | 0.0225461 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0225319 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0224714 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0223842 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0223175 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0222224 |
| CENPP | centromere protein P | 0.0220788 |
| ANLN | anillin, actin binding protein | 0.0220422 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0218897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.301164 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.272429 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0986063 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0864962 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0743814 |
| AHNAK | AHNAK nucleoprotein | -0.0718128 |
| STC1 | stanniocalcin 1 | -0.0691381 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0685778 |
| MTSS1 | metastasis suppressor 1 | -0.066981 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0665947 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0582482 |
| TMSB4X | thymosin beta 4, X-linked | -0.0578145 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0552152 |
| LAMC2 | laminin, gamma 2 | -0.0528697 |
| THBD | thrombomodulin | -0.0503798 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0492609 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0482411 |
| FLNB | filamin B, beta | -0.0478844 |
| VCL | vinculin | -0.0475495 |
| CAVIN1 | caveolae associated protein 1 | -0.0455717 |
| HLA-B | major histocompatibility complex, class I, B | -0.0454876 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0453903 |
| RCOR1 | REST corepressor 1 | -0.0443979 |
| RPS21 | ribosomal protein S21 | -0.0443504 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0430835 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0429602 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0428135 |
| HLA-E | major histocompatibility complex, class I, E | -0.0413692 |
| RPS24 | ribosomal protein S24 | -0.0410098 |
| CLIC4 | chloride intracellular channel 4 | -0.0409985 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0409141 |
| RPL26 | ribosomal protein L26 | -0.0399993 |
| PALLD | palladin, cytoskeletal associated protein | -0.0398209 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0390999 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0385412 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0380232 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0366164 |
| H1-0 | H1.0 linker histone | -0.0363887 |
| HM13 | histocompatibility (minor) 13 | -0.0362924 |
| ACTG1 | actin gamma 1 | -0.0360336 |
| RRBP1 | ribosome binding protein 1 | -0.0358771 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0358645 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.035856 |
| SQSTM1 | sequestosome 1 | -0.0352104 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0333094 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0328706 |
| EGR1 | early growth response 1 | -0.0324808 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0324693 |
| RPL12 | ribosomal protein L12 | -0.0324355 |
| GNAS | GNAS complex locus | -0.0322437 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0320526 |
| ARF1 | ADP-ribosylation factor 1 | -0.0316784 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0315042 |
| CD9 | CD9 molecule | -0.0315002 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0311499 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0305772 |
| TMSB10 | thymosin beta 10 | -0.0300317 |
| LDLR | low density lipoprotein receptor | -0.029982 |
| SQLE | squalene epoxidase | -0.0291312 |
| IGF2 | insulin-like growth factor 2 | -0.0290034 |
| PGK1 | phosphoglycerate kinase 1 | -0.0284458 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0283899 |
| PODXL | podocalyxin-like | -0.0279912 |
| INTS6 | integrator complex subunit 6 | -0.0277584 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0276922 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0273124 |
| RPL34 | ribosomal protein L34 | -0.0272491 |
| ANXA2 | annexin A2 | -0.0268378 |
| LAMA5 | laminin, alpha 5 | -0.0265648 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0264482 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0263455 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0255512 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0253709 |
| PRPF6 | pre-mRNA processing factor 6 | -0.0250414 |
| NAV2 | neuron navigator 2 | -0.0249565 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0248613 |
| LUZP1 | leucine zipper protein 1 | -0.0246557 |
| LDHA | lactate dehydrogenase A | -0.0246313 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0245932 |
| RPL36A | ribosomal protein L36a | -0.0245445 |
| TNS3 | tensin 3 | -0.0245166 |
| BCL2L1 | BCL2-like 1 | -0.0244994 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0244085 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0242003 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0241253 |
| RPL35A | ribosomal protein L35a | -0.0241252 |
| MIDN | midnolin | -0.0240679 |
| RPS8 | ribosomal protein S8 | -0.0239633 |
| S100A10 | S100 calcium binding protein A10 | -0.0238858 |
| PLEC | plectin | -0.0237964 |
| B2M | beta-2-microglobulin | -0.0235736 |
| HDLBP | high density lipoprotein binding protein | -0.0235228 |
| ACTN4 | actinin, alpha 4 | -0.0234759 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0232624 |
| CLDN1 | claudin 1 | -0.0232312 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0232064 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0231845 |
| KLF6 | Kruppel-like factor 6 | -0.0230724 |
| RPS6 | ribosomal protein S6 | -0.0229302 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0226959 |
