| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.154194 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.135507 |
| GDA | guanine deaminase | 0.087352 |
| MCU | mitochondrial calcium uniporter | 0.0695571 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0671212 |
| MYO1E | myosin IE | 0.0621074 |
| RRM2 | ribonucleotide reductase M2 | 0.0595425 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0561666 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0522601 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0488904 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0454843 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0451844 |
| AHR | aryl hydrocarbon receptor | 0.0440987 |
| EFNA5 | ephrin-A5 | 0.0438399 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0431772 |
| MYOF | myoferlin | 0.0431315 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0404967 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0400824 |
| EMP1 | epithelial membrane protein 1 | 0.0391438 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0379419 |
| SMAD3 | SMAD family member 3 | 0.036828 |
| RASEF | RAS and EF-hand domain containing | 0.0367262 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0352675 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0351117 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0348664 |
| HDAC9 | histone deacetylase 9 | 0.0346022 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0344903 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0340808 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0338508 |
| INTS6 | integrator complex subunit 6 | 0.0335881 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0323044 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0320531 |
| ANXA1 | annexin A1 | 0.0319068 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.031814 |
| MECOM | MDS1 and EVI1 complex locus | 0.0314547 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0313263 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0308964 |
| RPS12 | ribosomal protein S12 | 0.0305837 |
| SIK3 | SIK family kinase 3 | 0.0300349 |
| DST | dystonin | 0.0298269 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0297968 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0296683 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.0294372 |
| EFNB2 | ephrin-B2 | 0.0289301 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.028847 |
| ASPH | aspartate beta-hydroxylase | 0.0282868 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0282141 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0280839 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0280186 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0278289 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0277786 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0275129 |
| RPL37A | ribosomal protein L37a | 0.0274246 |
| RBM47 | RNA binding motif protein 47 | 0.0271598 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0270757 |
| CTBP2 | C-terminal binding protein 2 | 0.0269662 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0266237 |
| MKI67 | marker of proliferation Ki-67 | 0.026468 |
| POF1B | premature ovarian failure, 1B | 0.025993 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0251067 |
| EXPH5 | exophilin 5 | 0.0249279 |
| MUC13 | mucin 13, cell surface associated | 0.0246418 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0236818 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0233947 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0233453 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.023058 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0226931 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0225806 |
| NFIB | nuclear factor I/B | 0.0224142 |
| SGMS2 | sphingomyelin synthase 2 | 0.0223392 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0223001 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0219733 |
| SH3D19 | SH3 domain containing 19 | 0.0219718 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0219441 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0218752 |
| TJP1 | tight junction protein 1 | 0.0217628 |
| SEPTIN9 | septin 9 | 0.0213911 |
| FRMD5 | FERM domain containing 5 | 0.0213086 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.020869 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0206245 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0205758 |
| RPS6 | ribosomal protein S6 | 0.0203931 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0203531 |
| RPS3 | ribosomal protein S3 | 0.0203134 |
| CAPN8 | calpain 8 | 0.0198994 |
| TPM3 | tropomyosin 3 | 0.0197994 |
| PRSS3 | protease, serine, 3 | 0.0195721 |
| ECT2 | epithelial cell transforming 2 | 0.0195519 |
| SERINC5 | serine incorporator 5 | 0.0194369 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0193773 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0193749 |
| TLE4 | transducin-like enhancer of split 4 | 0.0189563 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0189473 |
| NOP56 | NOP56 ribonucleoprotein | 0.0188337 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0183848 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.0182627 |
| TOX3 | TOX high mobility group box family member 3 | 0.0182566 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0181017 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0180553 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0180477 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.200502 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.193066 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0894812 |
| H1-0 | H1.0 linker histone | -0.0850209 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0805569 |
| NPSR1 | neuropeptide S receptor 1 | -0.0770083 |
| GOLGA4 | golgin A4 | -0.0765713 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0740504 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0731331 |
| PGK1 | phosphoglycerate kinase 1 | -0.069785 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0648972 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0611766 |
| NDRG1 | N-myc downstream regulated 1 | -0.0605539 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0585217 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0555837 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0544568 |
| WDR45B | WD repeat domain 45B | -0.0530705 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.052222 |
| TMEM123 | transmembrane protein 123 | -0.0506298 |
| ATF5 | activating transcription factor 5 | -0.0503099 |
| ITGB4 | integrin, beta 4 | -0.0502147 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0495274 |
| KRT18 | keratin 18, type I | -0.0490498 |
| AGR2 | anterior gradient 2 | -0.0478935 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.046376 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0460274 |
| RRBP1 | ribosome binding protein 1 | -0.0454806 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0438581 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0421393 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0398047 |
| CANX | calnexin | -0.0397764 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0388907 |
| ZNF292 | zinc finger protein 292 | -0.0385444 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0382862 |
| FAT1 | FAT atypical cadherin 1 | -0.0378602 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0376867 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0376598 |
| S100A6 | S100 calcium binding protein A6 | -0.0376583 |
| HYOU1 | hypoxia up-regulated 1 | -0.0374846 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0367473 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0362922 |
| HM13 | histocompatibility (minor) 13 | -0.0361677 |
| RSF1 | remodeling and spacing factor 1 | -0.0352557 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0350328 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0340987 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0336264 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.033586 |
| CLTC | clathrin, heavy chain (Hc) | -0.0331714 |
| FTL | ferritin, light polypeptide | -0.0329817 |
| ANXA2 | annexin A2 | -0.0329436 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0324945 |
| CD2AP | CD2-associated protein | -0.0322711 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0322037 |
| TPM4 | tropomyosin 4 | -0.0315094 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0309288 |
| TMSB10 | thymosin beta 10 | -0.0300452 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0296528 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0291875 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.029146 |
| SPAG9 | sperm associated antigen 9 | -0.029089 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0290873 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0290134 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0289553 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0286971 |
| COG5 | component of oligomeric golgi complex 5 | -0.0285534 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0284924 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0278179 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0277817 |
| CLINT1 | clathrin interactor 1 | -0.0275809 |
| MUC17 | mucin 17, cell surface associated | -0.0273098 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0272879 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.027286 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0272732 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0272677 |
| VEGFA | vascular endothelial growth factor A | -0.0267679 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0267458 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0266663 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0266273 |
| RBM39 | RNA binding motif protein 39 | -0.0265976 |
| HMGA1 | high mobility group AT-hook 1 | -0.0264455 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0263112 |
| CALR | calreticulin | -0.0262561 |
| WASF2 | WAS protein family, member 2 | -0.0262234 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0261619 |
| ARCN1 | archain 1 | -0.0260692 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0258949 |
| POTEF | POTE ankyrin domain family, member F | -0.0258188 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0258158 |
| B2M | beta-2-microglobulin | -0.0257908 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0257496 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0255979 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0254353 |
| NF1 | neurofibromin 1 | -0.0253382 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0252834 |
| FAM13A | family with sequence similarity 13, member A | -0.0251314 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0251056 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0251007 |
| HDLBP | high density lipoprotein binding protein | -0.0246435 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0246263 |
| TPD52 | tumor protein D52 | -0.0245931 |
