| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.148779 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0606293 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0510257 |
| MYO1E | myosin IE | 0.0508797 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0486681 |
| RPS12 | ribosomal protein S12 | 0.0462371 |
| RPS6 | ribosomal protein S6 | 0.0415045 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.038646 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0376303 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0365913 |
| LMO7 | LIM domain 7 | 0.034369 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0333558 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0319611 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313707 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0311236 |
| RPS2 | ribosomal protein S2 | 0.0289343 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0281766 |
| RPS8 | ribosomal protein S8 | 0.0277259 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0268938 |
| AFF1 | AF4/FMR2 family, member 1 | 0.026701 |
| EGFR | epidermal growth factor receptor | 0.0254111 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0247353 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0239459 |
| POF1B | premature ovarian failure, 1B | 0.0239214 |
| PDZD8 | PDZ domain containing 8 | 0.0238465 |
| MUC13 | mucin 13, cell surface associated | 0.0238436 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0231097 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0223489 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0217872 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0214567 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0213435 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0206365 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0205844 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0205573 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0204608 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0199829 |
| AEBP2 | AE binding protein 2 | 0.0196767 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.019593 |
| SIK3 | SIK family kinase 3 | 0.0193606 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0187902 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.018409 |
| SMAD2 | SMAD family member 2 | 0.0183694 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0180071 |
| DUSP16 | dual specificity phosphatase 16 | 0.017794 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0177143 |
| INTS6 | integrator complex subunit 6 | 0.0170929 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0167529 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.016716 |
| RPL37A | ribosomal protein L37a | 0.0164055 |
| FOXP1 | forkhead box P1 | 0.0161496 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0159622 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0158041 |
| RPS17 | ribosomal protein S17 | 0.0154666 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.014823 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0147785 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0146845 |
| WWOX | WW domain containing oxidoreductase | 0.0142957 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0141275 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0139156 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0138073 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0138005 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0137695 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0136564 |
| ASPH | aspartate beta-hydroxylase | 0.0136561 |
| GDA | guanine deaminase | 0.0136335 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0135011 |
| NEBL | nebulette | 0.0134747 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.013438 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0133746 |
| PDE10A | phosphodiesterase 10A | 0.0132827 |
| RPL3 | ribosomal protein L3 | 0.0131804 |
| MT2A | metallothionein 2A | 0.0131356 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0131325 |
| HNF4G | hepatocyte nuclear factor 4, gamma | 0.0129824 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0129048 |
| PCNX2 | pecanex 2 | 0.0128475 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0128306 |
| DST | dystonin | 0.0127539 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0123123 |
| CEP128 | centrosomal protein 128kDa | 0.0121086 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0120895 |
| EPHA4 | EPH receptor A4 | 0.0119528 |
| B2M | beta-2-microglobulin | 0.0118907 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0118337 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0118242 |
| CENPP | centromere protein P | 0.0117987 |
| NABP1 | nucleic acid binding protein 1 | 0.0117094 |
| RPL9 | ribosomal protein L9 | 0.0116839 |
| RND3 | Rho family GTPase 3 | 0.0116287 |
| SVIL | supervillin | 0.0116048 |
| CFAP44 | cilia and flagella associated protein 44 | 0.0115823 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.0115209 |
| SGMS2 | sphingomyelin synthase 2 | 0.0114625 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0114314 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0113833 |
| SEPTIN9 | septin 9 | 0.0112258 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0111643 |
| CRY1 | cryptochrome circadian clock 1 | 0.0111415 |
| LAMA4 | laminin, alpha 4 | 0.0110822 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0109414 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.191076 |
| PTMA | prothymosin, alpha | -0.189097 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.161434 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.149463 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.142218 |
| TMSB10 | thymosin beta 10 | -0.130394 |
| ANXA2 | annexin A2 | -0.116063 |
| NPSR1 | neuropeptide S receptor 1 | -0.1129 |
| NDRG1 | N-myc downstream regulated 1 | -0.100483 |
| FLNB | filamin B, beta | -0.0903811 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0865407 |
| GOLGA4 | golgin A4 | -0.0766844 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0763966 |
| TNS4 | tensin 4 | -0.0721135 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0711437 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0707529 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0707083 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0657933 |
| TXNIP | thioredoxin interacting protein | -0.0651193 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.063535 |
| FAM13A | family with sequence similarity 13, member A | -0.0628915 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0620743 |
| LDHA | lactate dehydrogenase A | -0.0619301 |
| PGK1 | phosphoglycerate kinase 1 | -0.0618582 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0606382 |
| PIGR | polymeric immunoglobulin receptor | -0.0601306 |
| ITGA6 | integrin, alpha 6 | -0.0589547 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0587331 |
| EZR | ezrin | -0.0575528 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0545653 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0542195 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0529902 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0528833 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0518588 |
| KRT18 | keratin 18, type I | -0.0518507 |
| HMGA1 | high mobility group AT-hook 1 | -0.0517919 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0516601 |
| ACTN4 | actinin, alpha 4 | -0.0507042 |
| CALB1 | calbindin 1, 28kDa | -0.0499386 |
| S100A6 | S100 calcium binding protein A6 | -0.0486244 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0485907 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0482336 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0482188 |
| ITGB4 | integrin, beta 4 | -0.0477425 |
| SETD5 | SET domain containing 5 | -0.0475054 |
| WDR45B | WD repeat domain 45B | -0.04745 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0469402 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.046878 |
| TPM4 | tropomyosin 4 | -0.0467188 |
| RNF145 | ring finger protein 145 | -0.0456861 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0455832 |
| GPHN | gephyrin | -0.0455611 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0440424 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0439498 |
| CANX | calnexin | -0.0435343 |
| FERMT1 | fermitin family member 1 | -0.0433866 |
| MUC17 | mucin 17, cell surface associated | -0.042521 |
| H1-0 | H1.0 linker histone | -0.0424017 |
| ENO1 | enolase 1, (alpha) | -0.0422652 |
| EPCAM | epithelial cell adhesion molecule | -0.0422128 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.042083 |
| MED13L | mediator complex subunit 13-like | -0.0419639 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0409945 |
| MLEC | malectin | -0.0408332 |
| EREG | epiregulin | -0.0405321 |
| FNBP1L | formin binding protein 1-like | -0.0403835 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0401154 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0381404 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0378839 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0378786 |
| ZNF292 | zinc finger protein 292 | -0.0378362 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0375909 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0372913 |
| PKM | pyruvate kinase, muscle | -0.0370928 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0367655 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0367118 |
| CD46 | CD46 molecule, complement regulatory protein | -0.036457 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0356119 |
| CCNY | cyclin Y | -0.0354985 |
| EXOC1 | exocyst complex component 1 | -0.0352374 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0351059 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0350665 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.034908 |
| USP3 | ubiquitin specific peptidase 3 | -0.0348332 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0342095 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0336094 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0335022 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0334526 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0332954 |
| FOSL1 | FOS-like antigen 1 | -0.0332766 |
| WASF2 | WAS protein family, member 2 | -0.0332736 |
| KIF5B | kinesin family member 5B | -0.033069 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0330688 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0330478 |
| RBM39 | RNA binding motif protein 39 | -0.0329633 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0329263 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0328819 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0327475 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0324743 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0323572 |
