| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | 0.0683777 |
| RPL31 | ribosomal protein L31 | 0.0528198 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.051389 |
| RPL37A | ribosomal protein L37a | 0.0500603 |
| MT2A | metallothionein 2A | 0.048737 |
| RPL35A | ribosomal protein L35a | 0.045383 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0451194 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0422173 |
| HLA-A | major histocompatibility complex, class I, A | 0.0418276 |
| RPS12 | ribosomal protein S12 | 0.0400105 |
| RPL28 | ribosomal protein L28 | 0.0384866 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0376834 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0374854 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0368121 |
| RPS23 | ribosomal protein S23 | 0.0349788 |
| RPS17 | ribosomal protein S17 | 0.0344481 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.032991 |
| RPS29 | ribosomal protein S29 | 0.0328466 |
| RPS13 | ribosomal protein S13 | 0.0319941 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0310694 |
| RPS10 | ribosomal protein S10 | 0.0308545 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0289607 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0286877 |
| HDAC9 | histone deacetylase 9 | 0.0282088 |
| RPL9 | ribosomal protein L9 | 0.0267723 |
| CMIP | c-Maf inducing protein | 0.0258118 |
| RPLP2 | ribosomal protein, large, P2 | 0.0257777 |
| BRD2 | bromodomain containing 2 | 0.0254441 |
| PCBP2 | poly(rC) binding protein 2 | 0.0251638 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0249482 |
| PDE8A | phosphodiesterase 8A | 0.0244077 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0243009 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0240844 |
| PRKCE | protein kinase C, epsilon | 0.0240842 |
| B2M | beta-2-microglobulin | 0.0240452 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0239512 |
| RPS19 | ribosomal protein S19 | 0.0238215 |
| HELLS | helicase, lymphoid-specific | 0.0237506 |
| RPS6 | ribosomal protein S6 | 0.0237356 |
| FTO | fat mass and obesity associated | 0.0235915 |
| SIK3 | SIK family kinase 3 | 0.0231756 |
| INTS6 | integrator complex subunit 6 | 0.0225726 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0222794 |
| AEBP2 | AE binding protein 2 | 0.0220243 |
| HSPA8 | heat shock 70kDa protein 8 | 0.021698 |
| RCOR1 | REST corepressor 1 | 0.0210672 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0210009 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0208696 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0207335 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0207123 |
| PTK2 | protein tyrosine kinase 2 | 0.0205192 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.020488 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0204846 |
| CTBP2 | C-terminal binding protein 2 | 0.0203688 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0202414 |
| CEP128 | centrosomal protein 128kDa | 0.0201563 |
| SDC4 | syndecan 4 | 0.0200977 |
| RPL23 | ribosomal protein L23 | 0.0196676 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.019504 |
| CAPRIN2 | caprin family member 2 | 0.0193955 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0193818 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0193811 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0191565 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0191527 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0190585 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0190085 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0189432 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0189124 |
| RPL7A | ribosomal protein L7a | 0.0188053 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.018768 |
| UBE4B | ubiquitination factor E4B | 0.0187128 |
| EXOC6B | exocyst complex component 6B | 0.0185762 |
| ZNF638 | zinc finger protein 638 | 0.0184208 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0183746 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0183721 |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | 0.0183062 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0182574 |
| CEP192 | centrosomal protein 192kDa | 0.018193 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0180841 |
| RPS25 | ribosomal protein S25 | 0.0180462 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0179976 |
| FANCL | Fanconi anemia, complementation group L | 0.0179654 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0179291 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0176662 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0176529 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0174263 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0174051 |
| RPL11 | ribosomal protein L11 | 0.0171558 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0171348 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0170095 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0169659 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0169162 |
| TPM3 | tropomyosin 3 | 0.0168304 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0168077 |
| SRPK2 | SRSF protein kinase 2 | 0.016635 |
| SMYD3 | SET and MYND domain containing 3 | 0.0165904 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0164293 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0163984 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0162811 |
| MED13L | mediator complex subunit 13-like | 0.0162691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.281762 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.155027 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.143444 |
| SLC38A2 | solute carrier family 38, member 2 | -0.125347 |
| TMSB4X | thymosin beta 4, X-linked | -0.124779 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119832 |
| CANX | calnexin | -0.113561 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.108857 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.106177 |
| RAI1 | retinoic acid induced 1 | -0.0958663 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0957779 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0953681 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0934749 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0879305 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0877746 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0854508 |
| TXNRD1 | thioredoxin reductase 1 | -0.0841128 |
| CD44 | CD44 molecule (Indian blood group) | -0.079744 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0748658 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0746801 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0726232 |
| ACTG1 | actin gamma 1 | -0.071217 |
| LOC112694756 | uncharaterized LOC112694756 | -0.06605 |
| TMEM123 | transmembrane protein 123 | -0.064549 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0612631 |
| AHNAK | AHNAK nucleoprotein | -0.0612285 |
| HDLBP | high density lipoprotein binding protein | -0.0559998 |
| SRGN | serglycin | -0.0553563 |
| EHBP1 | EH domain binding protein 1 | -0.0546245 |
| PGK1 | phosphoglycerate kinase 1 | -0.054185 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0538231 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0528526 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0519762 |
| LDHA | lactate dehydrogenase A | -0.0516702 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.048471 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0478817 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0457087 |
| ANXA1 | annexin A1 | -0.0454859 |
| ENO1 | enolase 1, (alpha) | -0.0453002 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0435341 |
| FBXO11 | F-box protein 11 | -0.043454 |
| ZNF217 | zinc finger protein 217 | -0.04285 |
| VCL | vinculin | -0.0415584 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0415382 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0413143 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0410745 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0401279 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0400196 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0399908 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0399317 |
| EREG | epiregulin | -0.0395465 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0388694 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0388516 |
| CAVIN1 | caveolae associated protein 1 | -0.0384609 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0381 |
| TPM4 | tropomyosin 4 | -0.0380925 |
| EFNA5 | ephrin-A5 | -0.0379589 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0377091 |
| EPHA4 | EPH receptor A4 | -0.0373787 |
| EGR1 | early growth response 1 | -0.0366822 |
| PDE10A | phosphodiesterase 10A | -0.0366753 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0365219 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0363005 |
| EZR | ezrin | -0.0362591 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0360037 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0360001 |
| RIGI | RNA sensor RIG-I | -0.0359639 |
| COL5A2 | collagen, type V, alpha 2 | -0.0359156 |
| TMEM41B | transmembrane protein 41B | -0.035808 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0351855 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0350195 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.034953 |
| CADM2 | cell adhesion molecule 2 | -0.034691 |
| TUBB | tubulin, beta class I | -0.0346527 |
| RGS4 | regulator of G-protein signaling 4 | -0.0344151 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0339744 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0338027 |
| PRRC2B | proline-rich coiled-coil 2B | -0.033716 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0335829 |
| FLNB | filamin B, beta | -0.0331592 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0326805 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0325234 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0324211 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0320904 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0320352 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0317775 |
| KLF6 | Kruppel-like factor 6 | -0.0314801 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0310831 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0309019 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0306187 |
| RASAL2 | RAS protein activator like 2 | -0.0303585 |
| PHF3 | PHD finger protein 3 | -0.0300289 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0298795 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.029656 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0294042 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0293411 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0293396 |
| CCDC47 | coiled-coil domain containing 47 | -0.0291189 |
| PLK2 | polo-like kinase 2 | -0.0289877 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0287649 |
