| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.114038 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0961395 |
| EGFR | epidermal growth factor receptor | 0.0879067 |
| SLTM | SAFB-like, transcription modulator | 0.083298 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0725902 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0708842 |
| ASPH | aspartate beta-hydroxylase | 0.0690313 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0668687 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0639304 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0632661 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0563903 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0555143 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0552427 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0547662 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0511012 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.049722 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0479697 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0472375 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0429489 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0421671 |
| INTS6 | integrator complex subunit 6 | 0.0419838 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0419805 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0418432 |
| SMAD3 | SMAD family member 3 | 0.0407595 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0388092 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0383665 |
| SMYD3 | SET and MYND domain containing 3 | 0.0383664 |
| DOCK5 | dedicator of cytokinesis 5 | 0.037774 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0374455 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0361456 |
| EXT1 | exostosin glycosyltransferase 1 | 0.035853 |
| RAD51B | RAD51 paralog B | 0.0356503 |
| MCL1 | myeloid cell leukemia 1 | 0.035299 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0336743 |
| EFNA5 | ephrin-A5 | 0.0336731 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0331842 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0326817 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0325697 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0314279 |
| MYOF | myoferlin | 0.0313878 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0304154 |
| GPHN | gephyrin | 0.0303998 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0299549 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.029759 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0297054 |
| MAP7 | microtubule-associated protein 7 | 0.0284639 |
| SIK3 | SIK family kinase 3 | 0.0280679 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0279802 |
| VMP1 | vacuole membrane protein 1 | 0.0279538 |
| HOMER1 | homer scaffolding protein 1 | 0.0277635 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0273922 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0267021 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0266411 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0265931 |
| ZNF638 | zinc finger protein 638 | 0.0259728 |
| JMJD1C | jumonji domain containing 1C | 0.0257954 |
| MYO1E | myosin IE | 0.0255093 |
| PTK2 | protein tyrosine kinase 2 | 0.0254731 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0254359 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0252511 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0249213 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0242422 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0241434 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0230596 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0230534 |
| ATP11A | ATPase, class VI, type 11A | 0.0229498 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0222854 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222802 |
| FOXP1 | forkhead box P1 | 0.0219592 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0217284 |
| TES | testin LIM domain protein | 0.0215659 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0214953 |
| SUMF1 | sulfatase modifying factor 1 | 0.0214724 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0212869 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0212645 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0212287 |
| RNF213 | ring finger protein 213 | 0.0212141 |
| NPAS2 | neuronal PAS domain protein 2 | 0.021035 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0207086 |
| VCL | vinculin | 0.0205565 |
| VEGFC | vascular endothelial growth factor C | 0.020378 |
| BMP6 | bone morphogenetic protein 6 | 0.0202663 |
| KYNU | kynureninase | 0.0199592 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0199547 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.019828 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0198043 |
| WWOX | WW domain containing oxidoreductase | 0.0197549 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0196324 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0195274 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0193446 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0192042 |
| SP100 | SP100 nuclear antigen | 0.0191782 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0190916 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.018988 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0189497 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0188138 |
| GPC6 | glypican 6 | 0.0188042 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0187976 |
| DST | dystonin | 0.0187965 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0185659 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.218146 |
| TMSB10 | thymosin beta 10 | -0.0726783 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0707129 |
| ACTG1 | actin gamma 1 | -0.0435015 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0433808 |
| NDRG1 | N-myc downstream regulated 1 | -0.0430255 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0411634 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0397185 |
| FTL | ferritin, light polypeptide | -0.0348888 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0313505 |
| WASF2 | WAS protein family, member 2 | -0.0303003 |
| TMEM165 | transmembrane protein 165 | -0.0297434 |
| CST3 | cystatin C | -0.0295601 |
| EGR1 | early growth response 1 | -0.0282906 |
| H1-0 | H1.0 linker histone | -0.0270698 |
| TXNRD1 | thioredoxin reductase 1 | -0.0253069 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0247668 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0242251 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0231655 |
| HMGA1 | high mobility group AT-hook 1 | -0.0226238 |
| PTMA | prothymosin, alpha | -0.0224939 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0223247 |
| HDLBP | high density lipoprotein binding protein | -0.0218681 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0217361 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0216889 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0215135 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0203786 |
| S100A11 | S100 calcium binding protein A11 | -0.0202221 |
| SEC61G | Sec61 gamma subunit | -0.0200467 |
| WDR45B | WD repeat domain 45B | -0.0198042 |
| S100A10 | S100 calcium binding protein A10 | -0.0197058 |
| PKM | pyruvate kinase, muscle | -0.0192546 |
| PERP | PERP, TP53 apoptosis effector | -0.0191045 |
| LDHA | lactate dehydrogenase A | -0.018504 |
| RPL35A | ribosomal protein L35a | -0.0184063 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0181184 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0180967 |
| S100A6 | S100 calcium binding protein A6 | -0.017568 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0174289 |
| LAMC2 | laminin, gamma 2 | -0.0170509 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0170332 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0169324 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0168931 |
| PGK1 | phosphoglycerate kinase 1 | -0.0168527 |
| KRT7 | keratin 7, type II | -0.0164867 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0164755 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0162587 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0161879 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0159651 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.015599 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.015388 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0152125 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0151793 |
| AGR2 | anterior gradient 2 | -0.0150171 |
| RPL34 | ribosomal protein L34 | -0.0148387 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0146211 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0135362 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0135141 |
| KRT18 | keratin 18, type I | -0.0133627 |
| KRT19 | keratin 19, type I | -0.013215 |
| CCNI | cyclin I | -0.0131133 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0130858 |
| RPS24 | ribosomal protein S24 | -0.0130708 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0130558 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0130075 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0126682 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0126358 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0124873 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0124566 |
| RPLP1 | ribosomal protein, large, P1 | -0.0124439 |
| CANX | calnexin | -0.0124056 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0123452 |
| S100A9 | S100 calcium binding protein A9 | -0.0122978 |
| KRT8 | keratin 8, type II | -0.0122722 |
| GM2A | GM2 ganglioside activator | -0.0122594 |
| SEPTIN2 | septin 2 | -0.0122134 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0121661 |
| HLA-B | major histocompatibility complex, class I, B | -0.0121411 |
| RIN2 | Ras and Rab interactor 2 | -0.012101 |
| ARF1 | ADP-ribosylation factor 1 | -0.0120688 |
| CSTB | cystatin B (stefin B) | -0.0119827 |
| MGAT4C | MGAT4 family, member C | -0.0118323 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | -0.0117935 |
| JUP | junction plakoglobin | -0.011768 |
| MT2A | metallothionein 2A | -0.0113896 |
| TRIM56 | tripartite motif containing 56 | -0.0111461 |
| TKT | transketolase | -0.0111425 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0111342 |
| RIOK3 | RIO kinase 3 | -0.0111129 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0110949 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0110887 |
| ABLIM1 | actin binding LIM protein 1 | -0.0108027 |
| RPS25 | ribosomal protein S25 | -0.0107297 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0106282 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0106046 |
| PRRC2C | proline-rich coiled-coil 2C | -0.010492 |
| B2M | beta-2-microglobulin | -0.0103911 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0102816 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.010212 |
| SRP54 | signal recognition particle 54kDa | -0.0100594 |
