| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0664916 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0638114 |
| SMAD3 | SMAD family member 3 | 0.0633725 |
| HMGA2 | high mobility group AT-hook 2 | 0.0633351 |
| EFNA5 | ephrin-A5 | 0.0576718 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0573149 |
| PRELID2 | PRELI domain containing 2 | 0.0446822 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0436861 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0431734 |
| IFI44L | interferon-induced protein 44-like | 0.0395314 |
| INTS6 | integrator complex subunit 6 | 0.0387295 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0353588 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0347757 |
| AADAC | arylacetamide deacetylase | 0.034465 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0344059 |
| KYNU | kynureninase | 0.0310609 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0284846 |
| RAD51B | RAD51 paralog B | 0.0281786 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0280716 |
| FAM20C | family with sequence similarity 20, member C | 0.0279949 |
| EHBP1 | EH domain binding protein 1 | 0.0279171 |
| PRKCA | protein kinase C, alpha | 0.027466 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0270916 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0266068 |
| SUMF1 | sulfatase modifying factor 1 | 0.0260058 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0258766 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0257739 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0257622 |
| DST | dystonin | 0.0246774 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0245818 |
| ZNF804A | zinc finger protein 804A | 0.0240436 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0238928 |
| RAI14 | retinoic acid induced 14 | 0.0232298 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0223576 |
| ZNF638 | zinc finger protein 638 | 0.0217274 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0214964 |
| ASPH | aspartate beta-hydroxylase | 0.0212023 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0211895 |
| SP100 | SP100 nuclear antigen | 0.0210146 |
| GLIS3 | GLIS family zinc finger 3 | 0.0208687 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0205578 |
| RIGI | RNA sensor RIG-I | 0.0197484 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0196172 |
| ATXN1 | ataxin 1 | 0.0196047 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0192927 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0190724 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0186462 |
| SYT1 | synaptotagmin I | 0.0185822 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0184142 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0183063 |
| HDAC9 | histone deacetylase 9 | 0.0176241 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0173308 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0173057 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.017229 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0170308 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0166688 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0165445 |
| FER | fer (fps/fes related) tyrosine kinase | 0.016529 |
| IGSF1 | immunoglobulin superfamily, member 1 | 0.0160327 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0158669 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0156203 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0156105 |
| ANO6 | anoctamin 6 | 0.0155434 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0153779 |
| MIPOL1 | mirror-image polydactyly 1 | 0.0153494 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.015274 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.015247 |
| RARB | retinoic acid receptor, beta | 0.0152237 |
| SVIL | supervillin | 0.015094 |
| NABP1 | nucleic acid binding protein 1 | 0.0150543 |
| MX1 | MX dynamin-like GTPase 1 | 0.0150398 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0150044 |
| TGFB1 | transforming growth factor, beta 1 | 0.0149367 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0148442 |
| RUNX1 | runt-related transcription factor 1 | 0.0148233 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0148051 |
| R3HDM2 | R3H domain containing 2 | 0.0147368 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.014722 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0146982 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0146978 |
| PCDH7 | protocadherin 7 | 0.0145901 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0140589 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0139449 |
| PTK2 | protein tyrosine kinase 2 | 0.0138642 |
| AOPEP | aminopeptidase O (putative) | 0.0138361 |
| TBC1D5 | TBC1 domain family, member 5 | 0.013832 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0137744 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0136752 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0136734 |
| HDAC4 | histone deacetylase 4 | 0.0135904 |
| EXOC4 | exocyst complex component 4 | 0.0135723 |
| GALK2 | galactokinase 2 | 0.0135707 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0135258 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0134431 |
| PHF14 | PHD finger protein 14 | 0.0128625 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0127783 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0127303 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.0126721 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0125672 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.012469 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.207801 |
| TMSB10 | thymosin beta 10 | -0.167431 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.158595 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.140274 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.138195 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.136228 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.121256 |
| FN1 | fibronectin 1 | -0.0988064 |
| STC1 | stanniocalcin 1 | -0.0978868 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0913108 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0881931 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0857478 |
| PCBP2 | poly(rC) binding protein 2 | -0.0810022 |
| GOLGA4 | golgin A4 | -0.075371 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0731414 |
| FTL | ferritin, light polypeptide | -0.0693203 |
| LOX | lysyl oxidase | -0.0673284 |
| PTMA | prothymosin, alpha | -0.0660626 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0638752 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0621999 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0618602 |
| UBC | ubiquitin C | -0.0595344 |
| S100A6 | S100 calcium binding protein A6 | -0.0577066 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0564005 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0547573 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0519296 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0511781 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0494333 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0493579 |
| POTEF | POTE ankyrin domain family, member F | -0.0472916 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0461634 |
| CALR | calreticulin | -0.0459005 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0453481 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.044142 |
| MT2A | metallothionein 2A | -0.0429496 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.042839 |
| RPLP1 | ribosomal protein, large, P1 | -0.04239 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0423388 |
| CD44 | CD44 molecule (Indian blood group) | -0.0417913 |
| CANX | calnexin | -0.0410357 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0410018 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0400445 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0398263 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0395335 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0394636 |
| USP34 | ubiquitin specific peptidase 34 | -0.0394 |
| ENO1 | enolase 1, (alpha) | -0.0392929 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0391573 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0388682 |
| HMGA1 | high mobility group AT-hook 1 | -0.0382925 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0379553 |
| CALU | calumenin | -0.0376493 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0372835 |
| NRP1 | neuropilin 1 | -0.0364697 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0363559 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0363369 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0362901 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0360084 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0349265 |
| CDH13 | cadherin 13 | -0.0344784 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0341486 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.033803 |
| HDLBP | high density lipoprotein binding protein | -0.0330178 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0329464 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0326177 |
| RIOK3 | RIO kinase 3 | -0.0324839 |
| SETD5 | SET domain containing 5 | -0.0324206 |
| RPL23 | ribosomal protein L23 | -0.032201 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0321811 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0317853 |
| LDHA | lactate dehydrogenase A | -0.0316796 |
| TPM4 | tropomyosin 4 | -0.03163 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.031461 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.031403 |
| NDRG1 | N-myc downstream regulated 1 | -0.0313095 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0312609 |
| OSMR | oncostatin M receptor | -0.0311896 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0309636 |
| RPS19 | ribosomal protein S19 | -0.030835 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0302645 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0302568 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0301663 |
| SNX9 | sorting nexin 9 | -0.0292153 |
| COPA | coatomer protein complex, subunit alpha | -0.0291094 |
| MAP1B | microtubule-associated protein 1B | -0.0290255 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0287379 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.028309 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0281996 |
| MYADM | myeloid-associated differentiation marker | -0.0280226 |
| VEGFA | vascular endothelial growth factor A | -0.0279733 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0279403 |
| IER3 | immediate early response 3 | -0.0276575 |
| CLMP | CXADR-like membrane protein | -0.0271822 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0271332 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0270147 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -0.0269582 |
| B2M | beta-2-microglobulin | -0.0262748 |
| SPAG9 | sperm associated antigen 9 | -0.0257303 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0256068 |
| PGK1 | phosphoglycerate kinase 1 | -0.0253948 |
