Irinotecan_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMOC1 SPARC related modular calcium binding 1 0.0840548
PM20D1 peptidase M20 domain containing 1 0.0837281
KYNU kynureninase 0.0778674
PDE4D phosphodiesterase 4D, cAMP-specific 0.0707775
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.069302
EFNA5 ephrin-A5 0.0659212
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.059785
RPL37A ribosomal protein L37a 0.0530394
SAMD4A sterile alpha motif domain containing 4A 0.0514792
ZSWIM6 zinc finger, SWIM-type containing 6 0.0512707
BASP1 brain abundant, membrane attached signal protein 1 0.0512136
ARHGAP26 Rho GTPase activating protein 26 0.0506856
DOCK4 dedicator of cytokinesis 4 0.0502387
RPS8 ribosomal protein S8 0.04612
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0448383
GLIS3 GLIS family zinc finger 3 0.0446297
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0445468
HLA-B major histocompatibility complex, class I, B 0.0440041
ALCAM activated leukocyte cell adhesion molecule 0.0420576
EXT1 exostosin glycosyltransferase 1 0.0395989
INTS6 integrator complex subunit 6 0.0386563
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0374179
SOD2 superoxide dismutase 2, mitochondrial 0.0370095
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0360132
NEBL nebulette 0.0357497
CMIP c-Maf inducing protein 0.0352157
RPL31 ribosomal protein L31 0.0352065
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0350439
ATXN1 ataxin 1 0.034159
RPS12 ribosomal protein S12 0.0341464
RPS6 ribosomal protein S6 0.0338284
RPS17 ribosomal protein S17 0.0332169
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0328162
PTPRJ protein tyrosine phosphatase, receptor type, J 0.032098
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0310393
PRKD1 protein kinase D1 0.0306918
FGA fibrinogen alpha chain 0.0301599
FAM107B family with sequence similarity 107, member B 0.0284305
EHBP1 EH domain binding protein 1 0.0282686
HLA-A major histocompatibility complex, class I, A 0.0282436
GOLGB1 golgin B1 0.0278763
PDE10A phosphodiesterase 10A 0.0278485
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0276715
MAP7 microtubule-associated protein 7 0.027428
SPIDR scaffolding protein involved in DNA repair 0.0272484
UBASH3B ubiquitin associated and SH3 domain containing B 0.0271351
ANKRD12 ankyrin repeat domain 12 0.0268835
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0265218
RPS27A ribosomal protein S27a 0.0262876
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0257056
MIPOL1 mirror-image polydactyly 1 0.0256777
TRIP11 thyroid hormone receptor interactor 11 0.0252833
DST dystonin 0.0251995
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0250433
FMNL2 formin-like 2 0.0247911
NPAS2 neuronal PAS domain protein 2 0.0245082
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0244759
PRR16 proline rich 16 0.0244187
RPL13A ribosomal protein L13a 0.024234
RPS27 ribosomal protein S27 0.0240023
CUX1 cut-like homeobox 1 0.0238745
MBD5 methyl-CpG binding domain protein 5 0.0238512
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0237682
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0237588
RPS29 ribosomal protein S29 0.0232378
RPS3 ribosomal protein S3 0.0232364
RPS13 ribosomal protein S13 0.0232323
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0231732
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.023172
SIK3 SIK family kinase 3 0.0228571
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0227057
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0222741
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0220293
MAML3 mastermind-like 3 (Drosophila) 0.0220268
MYO1E myosin IE 0.021966
PCNX4 pecanex 4 0.021521
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0212353
BICD1 bicaudal D homolog 1 (Drosophila) 0.0212271
NCOA2 nuclear receptor coactivator 2 0.0212204
TTC28 tetratricopeptide repeat domain 28 0.0209255
NF1 neurofibromin 1 0.0209136
TPI1 triosephosphate isomerase 1 0.0206763
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0206464
SMAD2 SMAD family member 2 0.0206062
NBEAL1 neurobeachin-like 1 0.0204488
ZNF638 zinc finger protein 638 0.020311
PRELID2 PRELI domain containing 2 0.0201863
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0200624
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0199724
GCLC glutamate-cysteine ligase, catalytic subunit 0.0198805
RPS23 ribosomal protein S23 0.0196528
COL4A5 collagen, type IV, alpha 5 0.019612
NUMB numb homolog (Drosophila) 0.0195962
NLK nemo-like kinase 0.0195062
DOCK5 dedicator of cytokinesis 5 0.0194293
BRD2 bromodomain containing 2 0.0193582
MSRB3 methionine sulfoxide reductase B3 0.0193576
CAMKMT calmodulin-lysine N-methyltransferase 0.0193354
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0192442
CHD9 chromodomain helicase DNA binding protein 9 0.0191875

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.3169
GRAMD1B GRAM domain containing 1B -0.221204
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.182467
TXNRD1 thioredoxin reductase 1 -0.165614
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.153278
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.134592
TFPI2 tissue factor pathway inhibitor 2 -0.125305
TM4SF1 transmembrane 4 L six family member 1 -0.119376
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106348
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0988789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0950958
RTN4 reticulon 4 -0.0850481
AKAP12 A kinase (PRKA) anchor protein 12 -0.0836389
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0690612
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0690117
WDR43 WD repeat domain 43 -0.0641813
RBM39 RNA binding motif protein 39 -0.0619303
ACTG1 actin gamma 1 -0.0574329
NAMPT nicotinamide phosphoribosyltransferase -0.0564518
PFDN2 prefoldin subunit 2 -0.0563913
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0553962
USP3 ubiquitin specific peptidase 3 -0.0530356
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0513516
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0501295
RAD21 RAD21 homolog (S. pombe) -0.0492127
IER3 immediate early response 3 -0.0483134
IGF2 insulin-like growth factor 2 -0.0476002
YBX3 Y box binding protein 3 -0.0469357
ZFAND3 zinc finger, AN1-type domain 3 -0.0467192
TPM4 tropomyosin 4 -0.0464918
SLC38A1 solute carrier family 38, member 1 -0.0454064
FTL ferritin, light polypeptide -0.0452949
NOP58 NOP58 ribonucleoprotein -0.0445211
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.04426
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0435272
BIRC3 baculoviral IAP repeat containing 3 -0.042941
DGKD diacylglycerol kinase, delta 130kDa -0.0425053
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0423633
RBM25 RNA binding motif protein 25 -0.0415973
PTMA prothymosin, alpha -0.0415394
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0412201
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0396612
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0395819
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0388758
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0380085
SPAG9 sperm associated antigen 9 -0.0380029
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0377201
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0364611
ASPH aspartate beta-hydroxylase -0.0362798
ANXA2 annexin A2 -0.0362475
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0362346
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0361484
KLF6 Kruppel-like factor 6 -0.0355095
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0353791
ADAM17 ADAM metallopeptidase domain 17 -0.0353704
ERBIN erbb2 interacting protein -0.0353387
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0351618
UPP1 uridine phosphorylase 1 -0.0349329
ZNF292 zinc finger protein 292 -0.0347918
NCEH1 neutral cholesterol ester hydrolase 1 -0.0347562
MATR3 matrin 3 -0.0346014
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0344403
MIS18BP1 MIS18 binding protein 1 -0.033712
TMSB10 thymosin beta 10 -0.0336849
PDIA6 protein disulfide isomerase family A, member 6 -0.0336585
CYRIB CYFIP related Rac1 interactor B -0.0335092
NUP58 nucleoporin 58 -0.033236
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0331353
KPNB1 karyopherin (importin) beta 1 -0.0331168
ZNF207 zinc finger protein 207 -0.0330565
PAWR PRKC, apoptosis, WT1, regulator -0.0327664
TFG TRK-fused gene -0.0325135
KDM3A lysine (K)-specific demethylase 3A -0.0324505
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0322751
CANX calnexin -0.0319715
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0316443
ACTN1 actinin, alpha 1 -0.0315451
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0313932
S100A6 S100 calcium binding protein A6 -0.031088
RHEB Ras homolog enriched in brain -0.0308783
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0307831
TMEM123 transmembrane protein 123 -0.030335
ANLN anillin, actin binding protein -0.030323
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0302726
EGR1 early growth response 1 -0.0301475
PARD3 par-3 family cell polarity regulator -0.030051
TPD52 tumor protein D52 -0.029818
APP amyloid beta (A4) precursor protein -0.0294296
MORF4L1 mortality factor 4 like 1 -0.0288566
BCLAF1 BCL2-associated transcription factor 1 -0.0283607
CCNL1 cyclin L1 -0.028306
POTEF POTE ankyrin domain family, member F -0.0280794
PDIA3 protein disulfide isomerase family A, member 3 -0.0280362
YME1L1 YME1-like 1 ATPase -0.0278135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0278066
MYOF myoferlin -0.0277569
WWOX WW domain containing oxidoreductase -0.0271607
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0271463
VEZT vezatin, adherens junctions transmembrane protein -0.0271304
DENND4A DENN/MADD domain containing 4A -0.0269501