| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.129827 |
| KYNU | kynureninase | 0.0838853 |
| EZR | ezrin | 0.0736211 |
| INTS6 | integrator complex subunit 6 | 0.0703256 |
| KRT17 | keratin 17, type I | 0.0692113 |
| PTMA | prothymosin, alpha | 0.0522824 |
| STEAP4 | STEAP family member 4 | 0.0515162 |
| GOLGB1 | golgin B1 | 0.0506008 |
| RPL31 | ribosomal protein L31 | 0.0504293 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0503225 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0495133 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0485149 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0474987 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0465974 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0464492 |
| RPS3 | ribosomal protein S3 | 0.0436619 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0429565 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0429135 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0420236 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0417254 |
| EFNA5 | ephrin-A5 | 0.0415883 |
| RAD51B | RAD51 paralog B | 0.0414817 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0401182 |
| ANXA2 | annexin A2 | 0.0394105 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0391201 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0386503 |
| B2M | beta-2-microglobulin | 0.0371863 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0365772 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0358076 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0357076 |
| ATP11A | ATPase, class VI, type 11A | 0.0350211 |
| RPL36A | ribosomal protein L36a | 0.0349786 |
| RBM39 | RNA binding motif protein 39 | 0.0347033 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0345251 |
| RPS12 | ribosomal protein S12 | 0.0342422 |
| GLG1 | golgi glycoprotein 1 | 0.0341275 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0332224 |
| MYO1E | myosin IE | 0.0332219 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0331265 |
| PRRC2C | proline-rich coiled-coil 2C | 0.032528 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0324292 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0324168 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0322108 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.031981 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.031868 |
| PRKCA | protein kinase C, alpha | 0.0317359 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0317351 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0316869 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0316516 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0311929 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0311376 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0309782 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0308554 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0308207 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0306902 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0305738 |
| ASPH | aspartate beta-hydroxylase | 0.0302983 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.030169 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.029682 |
| ZNF148 | zinc finger protein 148 | 0.029585 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0292805 |
| RPS4X | ribosomal protein S4, X-linked | 0.0292247 |
| TAOK1 | TAO kinase 1 | 0.0291865 |
| BRD4 | bromodomain containing 4 | 0.0291539 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0291096 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0290532 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0290057 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0289575 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0285846 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0285258 |
| AREG | amphiregulin | 0.0283776 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0283227 |
| H3-3B | H3.3 histone B | 0.0282199 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0281037 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.027899 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0276662 |
| CDK6 | cyclin-dependent kinase 6 | 0.0276439 |
| KMT5B | lysine methyltransferase 5B | 0.0275966 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0274064 |
| TUFT1 | tuftelin 1 | 0.0271412 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0268104 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0267883 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0266703 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0264712 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0263534 |
| SLFN5 | schlafen family member 5 | 0.0263251 |
| RPS17 | ribosomal protein S17 | 0.0262493 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0261156 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0260292 |
| RPLP2 | ribosomal protein, large, P2 | 0.0259867 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0257066 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0255244 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0254212 |
| RPS6 | ribosomal protein S6 | 0.0252766 |
| KLHDC10 | kelch domain containing 10 | 0.0252111 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0251832 |
| SRP54 | signal recognition particle 54kDa | 0.0250627 |
| VGLL3 | vestigial-like family member 3 | 0.0250164 |
| RPL11 | ribosomal protein L11 | 0.0249538 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0247466 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.291123 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.197572 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118449 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0987195 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0974742 |
| EGFR | epidermal growth factor receptor | -0.080407 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0702077 |
| ABHD17C | abhydrolase domain containing 17C | -0.068388 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0680731 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0627127 |
| FAM13A | family with sequence similarity 13, member A | -0.0612294 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0606997 |
| ATOSA | atos homolog A | -0.056758 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0555661 |
| TXNRD1 | thioredoxin reductase 1 | -0.0554269 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0550463 |
| LMO7 | LIM domain 7 | -0.0549084 |
| DSCAM | Down syndrome cell adhesion molecule | -0.053361 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0525336 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0519072 |
| FLNB | filamin B, beta | -0.0514984 |
| FBXO11 | F-box protein 11 | -0.0512995 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0506988 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0497322 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0490146 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.048421 |
| ERBIN | erbb2 interacting protein | -0.0478063 |
| FMNL2 | formin-like 2 | -0.0477966 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0468027 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0462069 |
| RPL35A | ribosomal protein L35a | -0.0457256 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0455916 |
| ZNF292 | zinc finger protein 292 | -0.0451432 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0436813 |
| LAMC2 | laminin, gamma 2 | -0.0426452 |
| NPTN | neuroplastin | -0.042456 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0418822 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0404918 |
| ADM | adrenomedullin | -0.040061 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0399503 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0394532 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0388257 |
| MMP12 | matrix metallopeptidase 12 | -0.038632 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0381987 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0381475 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0368858 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0366326 |
| HDLBP | high density lipoprotein binding protein | -0.0363207 |
| CCNI | cyclin I | -0.036196 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0358962 |
| NDRG1 | N-myc downstream regulated 1 | -0.035849 |
| TMEM165 | transmembrane protein 165 | -0.0355681 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0354948 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0352043 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.034979 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0347577 |
| ABI1 | abl-interactor 1 | -0.0347522 |
| MXD1 | MAX dimerization protein 1 | -0.0346463 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0346105 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0341511 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0336736 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0336334 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0333175 |
| ACTG1 | actin gamma 1 | -0.0330139 |
| PTK2 | protein tyrosine kinase 2 | -0.0325329 |
| SDCBP | syndecan binding protein (syntenin) | -0.0322433 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0320964 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0316416 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0316333 |
| PDE8A | phosphodiesterase 8A | -0.0311997 |
| KLF6 | Kruppel-like factor 6 | -0.0308716 |
| XPO1 | exportin 1 | -0.0305506 |
| SFTPA2 | surfactant protein A2 | -0.0304153 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0304072 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0303745 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0302251 |
| ZNF706 | zinc finger protein 706 | -0.0301932 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0301073 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.030054 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0297968 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0297402 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0297238 |
| CSNK1E | casein kinase 1, epsilon | -0.0282265 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0281503 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0281234 |
| RAI14 | retinoic acid induced 14 | -0.0281224 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0280056 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0278363 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0276361 |
| ATF6 | activating transcription factor 6 | -0.0276359 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0274353 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.027399 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.027108 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0270776 |
| MEF2A | myocyte enhancer factor 2A | -0.0269752 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0266351 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -0.0265927 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0265896 |
| CDK17 | cyclin-dependent kinase 17 | -0.0265126 |
| THRB | thyroid hormone receptor, beta | -0.026434 |
