Irinotecan_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.197424
TPM3 tropomyosin 3 0.118658
YBX3 Y box binding protein 3 0.105035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0966059
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0904643
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0904253
RPS12 ribosomal protein S12 0.0881423
TPI1 triosephosphate isomerase 1 0.0872081
RPS3 ribosomal protein S3 0.0843719
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0819751
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0789649
ZSWIM6 zinc finger, SWIM-type containing 6 0.0699995
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0687752
RPS6 ribosomal protein S6 0.0658807
RPL37A ribosomal protein L37a 0.0644561
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0619426
ZCCHC7 zinc finger, CCHC domain containing 7 0.060732
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0606637
BRD2 bromodomain containing 2 0.060302
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0599374
HSPA8 heat shock 70kDa protein 8 0.05756
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0557036
INTS6 integrator complex subunit 6 0.0539512
RRM2 ribonucleotide reductase M2 0.0535278
RPS8 ribosomal protein S8 0.0524953
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.046085
MCL1 myeloid cell leukemia 1 0.0454241
YBX1 Y box binding protein 1 0.0436562
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.043584
FMNL2 formin-like 2 0.0433102
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0425015
RPS27 ribosomal protein S27 0.0417403
RPS10 ribosomal protein S10 0.0409033
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0391002
EEF1G eukaryotic translation elongation factor 1 gamma 0.0385186
RPS2 ribosomal protein S2 0.0384619
HOMER1 homer scaffolding protein 1 0.0382685
JMJD1C jumonji domain containing 1C 0.0376072
RPL37 ribosomal protein L37 0.0367682
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0365047
SFPQ splicing factor proline/glutamine-rich 0.0364982
PRKCE protein kinase C, epsilon 0.0357266
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0353036
SIK3 SIK family kinase 3 0.0352245
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0350742
VMP1 vacuole membrane protein 1 0.0350646
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0342596
SET SET nuclear proto-oncogene 0.0341672
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0340382
PA2G4 proliferation-associated 2G4, 38kDa 0.0334603
IFI6 interferon, alpha-inducible protein 6 0.03312
GOLGB1 golgin B1 0.0329715
KTN1 kinectin 1 (kinesin receptor) 0.0322775
EIF5B eukaryotic translation initiation factor 5B 0.0321835
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0317148
AEBP2 AE binding protein 2 0.0315619
RPS17 ribosomal protein S17 0.0313883
TPM2 tropomyosin 2 (beta) 0.0313744
PDLIM5 PDZ and LIM domain 5 0.030572
C6ORF62 chromosome 6 open reading frame 62 0.0302491
YAP1 Yes-associated protein 1 0.030245
VCP valosin containing protein 0.0300933
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.030072
RCOR1 REST corepressor 1 0.0298738
PDE4D phosphodiesterase 4D, cAMP-specific 0.029667
RPL27 ribosomal protein L27 0.0294263
RPS19 ribosomal protein S19 0.0285243
RPL3 ribosomal protein L3 0.0283175
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0282698
SERBP1 SERPINE1 mRNA binding protein 1 0.027861
RPL11 ribosomal protein L11 0.0276734
GRAMD1B GRAM domain containing 1B 0.0276694
SNAP25 synaptosomal-associated protein, 25kDa 0.0271367
CEP128 centrosomal protein 128kDa 0.0269977
IPO7 importin 7 0.0266985
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0266296
PNN pinin, desmosome associated protein 0.0262329
MKI67 marker of proliferation Ki-67 0.0262301
BCLAF1 BCL2-associated transcription factor 1 0.0261388
PCBP2 poly(rC) binding protein 2 0.0260284
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.025367
ZBTB1 zinc finger and BTB domain containing 1 0.0253471
DSPP dentin sialophosphoprotein 0.0252774
CREM cAMP responsive element modulator 0.0250684
AFF3 AF4/FMR2 family, member 3 0.0249844
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0249628
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0247818
ANO6 anoctamin 6 0.0247818
B2M beta-2-microglobulin 0.0247126
RPL26 ribosomal protein L26 0.0246125
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0246056
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.024523
FUS FUS RNA binding protein 0.024428
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0244216
RPS29 ribosomal protein S29 0.024172
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0237967
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.023745
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0237445
RPL7A ribosomal protein L7a 0.0236082
SDK1 sidekick cell adhesion molecule 1 0.0235479

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.169558
TXNRD1 thioredoxin reductase 1 -0.142461
TFPI2 tissue factor pathway inhibitor 2 -0.136973
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0942556
KDM3A lysine (K)-specific demethylase 3A -0.0796742
THSD4 thrombospondin, type I, domain containing 4 -0.0773526
ZBTB20 zinc finger and BTB domain containing 20 -0.0694181
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0668976
TRIO trio Rho guanine nucleotide exchange factor -0.0652023
RAD51B RAD51 paralog B -0.0630964
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0578335
ACTG1 actin gamma 1 -0.054622
NCOA7 nuclear receptor coactivator 7 -0.0542713
MYL12B myosin, light chain 12B, regulatory -0.0473019
TMSB10 thymosin beta 10 -0.0454637
PGK1 phosphoglycerate kinase 1 -0.0443482
PTMA prothymosin, alpha -0.0433028
SBF2 SET binding factor 2 -0.0428054
CAVIN1 caveolae associated protein 1 -0.04225
ZFR zinc finger RNA binding protein -0.0422251
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0414604
KPNB1 karyopherin (importin) beta 1 -0.0413213
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0411227
XPO1 exportin 1 -0.0406997
TMEM165 transmembrane protein 165 -0.0401103
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0400289
BCAS3 breast carcinoma amplified sequence 3 -0.039479
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0392878
RUSC2 RUN and SH3 domain containing 2 -0.0386586
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.03817
LMAN1 lectin, mannose-binding, 1 -0.0379558
WASF2 WAS protein family, member 2 -0.0373803
RTN4 reticulon 4 -0.037363
CCND2 cyclin D2 -0.0371248
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0368507
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0368341
VIM vimentin -0.0366938
RPL35A ribosomal protein L35a -0.0366852
SRP72 signal recognition particle 72kDa -0.0365683
KDM4B lysine (K)-specific demethylase 4B -0.0362753
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.035512
ZNF292 zinc finger protein 292 -0.0352204
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0352012
ICAM1 intercellular adhesion molecule 1 -0.0351785
ZMYND8 zinc finger, MYND-type containing 8 -0.0349521
RAB1A RAB1A, member RAS oncogene family -0.0346454
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0346419
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0344476
NF1 neurofibromin 1 -0.0340585
S100A6 S100 calcium binding protein A6 -0.033024
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0330059
AHNAK AHNAK nucleoprotein -0.0329695
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0327925
BBX bobby sox homolog (Drosophila) -0.0326557
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0322902
BRWD3 bromodomain and WD repeat domain containing 3 -0.0319711
ANKRD12 ankyrin repeat domain 12 -0.0317745
CANX calnexin -0.0317239
IGF1R insulin-like growth factor 1 receptor -0.0317104
WSB1 WD repeat and SOCS box containing 1 -0.0316283
H1-0 H1.0 linker histone -0.0315719
RPS24 ribosomal protein S24 -0.0314865
TAS2R14 taste receptor, type 2, member 14 -0.0313834
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0312594
BSG basigin (Ok blood group) -0.0310137
KLF6 Kruppel-like factor 6 -0.0309179
IGF2 insulin-like growth factor 2 -0.0306339
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.03012
CTTNBP2NL CTTNBP2 N-terminal like -0.0296146
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.029249
LOC112694756 uncharaterized LOC112694756 -0.0290698
MAP4 microtubule-associated protein 4 -0.0289687
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0285667
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0282957
BLTP2 bridge-like lipid transfer protein family member 2 -0.0282573
TLK1 tousled-like kinase 1 -0.0282241
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0277664
NCOR1 nuclear receptor corepressor 1 -0.0274713
FBXO11 F-box protein 11 -0.027157
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0270115
BIRC6 baculoviral IAP repeat containing 6 -0.0269034
BASP1 brain abundant, membrane attached signal protein 1 -0.0265901
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0265197
EPN2 epsin 2 -0.0264766
EGFR epidermal growth factor receptor -0.0263817
HDLBP high density lipoprotein binding protein -0.0263401
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0260813
PTPRF protein tyrosine phosphatase, receptor type, F -0.025942
RNF169 ring finger protein 169 -0.0258202
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0254572
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0254165
ZNF217 zinc finger protein 217 -0.025244
SINHCAF SIN3-HDAC complex associated factor -0.0250768
KMT2C lysine (K)-specific methyltransferase 2C -0.025022
ACTN1 actinin, alpha 1 -0.0246239
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0245536
KCMF1 potassium channel modulatory factor 1 -0.0243351
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0243156
OSMR oncostatin M receptor -0.0242283
WDR45B WD repeat domain 45B -0.0241232