| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.14803 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.121246 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0957845 |
| NDRG1 | N-myc downstream regulated 1 | 0.0948787 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0839362 |
| EFNA5 | ephrin-A5 | 0.0764245 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0752324 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0708411 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.066005 |
| GOLGB1 | golgin B1 | 0.0648248 |
| RAD51B | RAD51 paralog B | 0.0604396 |
| DSPP | dentin sialophosphoprotein | 0.0589962 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0565131 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0544108 |
| KIAA1217 | KIAA1217 | 0.0526957 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0524524 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0522141 |
| AHNAK | AHNAK nucleoprotein | 0.0504354 |
| MX1 | MX dynamin-like GTPase 1 | 0.0497097 |
| PTK2 | protein tyrosine kinase 2 | 0.0493633 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0488706 |
| RPS12 | ribosomal protein S12 | 0.0487278 |
| FHIT | fragile histidine triad | 0.0486817 |
| TPM3 | tropomyosin 3 | 0.0482777 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0458888 |
| MCL1 | myeloid cell leukemia 1 | 0.0451511 |
| ANO6 | anoctamin 6 | 0.0449196 |
| RPS6 | ribosomal protein S6 | 0.0448411 |
| INTS6 | integrator complex subunit 6 | 0.0422862 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0421885 |
| SMAD3 | SMAD family member 3 | 0.0421801 |
| BRD2 | bromodomain containing 2 | 0.0413947 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0412022 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0410507 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0409824 |
| HDAC9 | histone deacetylase 9 | 0.0402247 |
| PRKCA | protein kinase C, alpha | 0.0399849 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0398406 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0395461 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0394436 |
| FBXO32 | F-box protein 32 | 0.0388669 |
| DTNA | dystrobrevin, alpha | 0.0388242 |
| MSN | moesin | 0.0380445 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0377909 |
| IFI44L | interferon-induced protein 44-like | 0.0372281 |
| MX2 | MX dynamin-like GTPase 2 | 0.0361291 |
| ATXN1 | ataxin 1 | 0.0358996 |
| VEGFA | vascular endothelial growth factor A | 0.0358953 |
| RIGI | RNA sensor RIG-I | 0.0358473 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0358082 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0355795 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0350557 |
| G0S2 | G0/G1 switch 2 | 0.0347666 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.034079 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0336794 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0334621 |
| RNF213 | ring finger protein 213 | 0.0333873 |
| NAV2 | neuron navigator 2 | 0.0331383 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0330966 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0330011 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0323664 |
| MYO5B | myosin VB | 0.0322792 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0320689 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0320242 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0318501 |
| SEPTIN11 | septin 11 | 0.031818 |
| ENO1 | enolase 1, (alpha) | 0.0317443 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0315509 |
| RAI14 | retinoic acid induced 14 | 0.0311543 |
| SGMS2 | sphingomyelin synthase 2 | 0.0311096 |
| CD44 | CD44 molecule (Indian blood group) | 0.0310934 |
| SMYD3 | SET and MYND domain containing 3 | 0.0308972 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0301063 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0293996 |
| RUNX1 | runt-related transcription factor 1 | 0.0291607 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0288648 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0285887 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.028531 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0282985 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0281147 |
| ETV6 | ets variant 6 | 0.0279421 |
| ARRDC3 | arrestin domain containing 3 | 0.0279123 |
| MT2A | metallothionein 2A | 0.0277668 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0276926 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0275767 |
| USP53 | ubiquitin specific peptidase 53 | 0.0275589 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0274933 |
| VGLL3 | vestigial-like family member 3 | 0.0274709 |
| SDC4 | syndecan 4 | 0.0272767 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0271853 |
| RAB10 | RAB10, member RAS oncogene family | 0.0271726 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0270206 |
| SEPTIN9 | septin 9 | 0.0268763 |
| FTL | ferritin, light polypeptide | 0.0267853 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0266429 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0263657 |
| RPL37A | ribosomal protein L37a | 0.0263154 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0261596 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.026043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0258206 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.290796 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.259307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.111247 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.106296 |
| PTMA | prothymosin, alpha | -0.0977848 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0942109 |
| ACTG1 | actin gamma 1 | -0.0939556 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0833676 |
| RAD21 | RAD21 homolog (S. pombe) | -0.07816 |
| PGK1 | phosphoglycerate kinase 1 | -0.0717282 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0672138 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0654519 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0647602 |
| TOP1 | topoisomerase (DNA) I | -0.0638258 |
| LMO7 | LIM domain 7 | -0.0624495 |
| TFG | TRK-fused gene | -0.0617292 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0598206 |
| CD2AP | CD2-associated protein | -0.0587512 |
| ASPH | aspartate beta-hydroxylase | -0.0586343 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0584939 |
| TSC22D2 | TSC22 domain family, member 2 | -0.056483 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0555544 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0529947 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0512912 |
| TMSB4X | thymosin beta 4, X-linked | -0.0503961 |
| GOLGA4 | golgin A4 | -0.0503937 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0496836 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0488434 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0485723 |
| S100A6 | S100 calcium binding protein A6 | -0.0485014 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0482023 |
| ARF1 | ADP-ribosylation factor 1 | -0.0470582 |
| TMEM263 | transmembrane protein 263 | -0.0466324 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0459581 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0452075 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0451304 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0441411 |
| TMSB10 | thymosin beta 10 | -0.0438533 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0431575 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0430655 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.04247 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0421094 |
| HMGB2 | high mobility group box 2 | -0.0415525 |
| FAM3C | family with sequence similarity 3, member C | -0.0405581 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0405083 |
| CALU | calumenin | -0.0404337 |
| RBM39 | RNA binding motif protein 39 | -0.0401902 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.040138 |
| TPM4 | tropomyosin 4 | -0.0399909 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0398247 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0396848 |
| TMEM123 | transmembrane protein 123 | -0.0387748 |
| COPA | coatomer protein complex, subunit alpha | -0.038624 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0381007 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.037838 |
| RNF145 | ring finger protein 145 | -0.0375724 |
| CDC73 | cell division cycle 73 | -0.0371796 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0371085 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0370746 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0368258 |
| SLMAP | sarcolemma associated protein | -0.0368248 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0360535 |
| CANX | calnexin | -0.0357192 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0355531 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.034751 |
| GNAS | GNAS complex locus | -0.0342701 |
| USP3 | ubiquitin specific peptidase 3 | -0.032342 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0320136 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0315915 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0314443 |
| SPAG9 | sperm associated antigen 9 | -0.0313608 |
| RHEB | Ras homolog enriched in brain | -0.0307641 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0307527 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0306667 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0299503 |
| RBM25 | RNA binding motif protein 25 | -0.0292013 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0290233 |
| MATR3 | matrin 3 | -0.0289782 |
| CDK17 | cyclin-dependent kinase 17 | -0.0287315 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0286976 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0286674 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0286654 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0283132 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0283012 |
| WTAP | Wilms tumor 1 associated protein | -0.0281376 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0275296 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0273684 |
| ANXA2 | annexin A2 | -0.0273118 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0271659 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0268822 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0264999 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0263397 |
| CCND1 | cyclin D1 | -0.026264 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0260596 |
| CLINT1 | clathrin interactor 1 | -0.025766 |
| EREG | epiregulin | -0.0255024 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0251443 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0250384 |
| TMEM39A | transmembrane protein 39A | -0.024825 |
| MORF4L1 | mortality factor 4 like 1 | -0.0248191 |
