| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.205258 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.165533 |
| PDE10A | phosphodiesterase 10A | 0.083537 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0773343 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0705012 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0678073 |
| RPS6 | ribosomal protein S6 | 0.0607055 |
| KYNU | kynureninase | 0.0590988 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0581211 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0577262 |
| DST | dystonin | 0.056237 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0548096 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0494917 |
| SMAD2 | SMAD family member 2 | 0.0455553 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.044509 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0403361 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0385549 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0378154 |
| MAP7 | microtubule-associated protein 7 | 0.0362278 |
| RPS12 | ribosomal protein S12 | 0.0358838 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0337531 |
| RPL37A | ribosomal protein L37a | 0.0337502 |
| RPS8 | ribosomal protein S8 | 0.0335397 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0323811 |
| PDE7B | phosphodiesterase 7B | 0.0315476 |
| PDLIM5 | PDZ and LIM domain 5 | 0.030273 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0295212 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0273522 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0270305 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0269555 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0258503 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0258298 |
| FMNL2 | formin-like 2 | 0.0257936 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0257726 |
| PRELID2 | PRELI domain containing 2 | 0.0255566 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0252378 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.025184 |
| XYLT1 | xylosyltransferase I | 0.0251715 |
| CHL1 | cell adhesion molecule L1-like | 0.0243551 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0239608 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0238663 |
| INTS6 | integrator complex subunit 6 | 0.0232024 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0227986 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0227305 |
| RAD51B | RAD51 paralog B | 0.0226659 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0218863 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0217729 |
| RPL31 | ribosomal protein L31 | 0.0208479 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0197204 |
| RPS17 | ribosomal protein S17 | 0.0190525 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0190311 |
| RPS2 | ribosomal protein S2 | 0.0189794 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0188929 |
| NRXN3 | neurexin 3 | 0.0188878 |
| CADM2 | cell adhesion molecule 2 | 0.0188526 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0188507 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0187473 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0185935 |
| RPL9 | ribosomal protein L9 | 0.0183255 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0180885 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0180537 |
| FAM107B | family with sequence similarity 107, member B | 0.018027 |
| DENND1A | DENN/MADD domain containing 1A | 0.0171534 |
| RPS23 | ribosomal protein S23 | 0.0171505 |
| AUTS2 | autism susceptibility candidate 2 | 0.0170775 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0168852 |
| RPL26 | ribosomal protein L26 | 0.0166581 |
| FNIP1 | folliculin interacting protein 1 | 0.0166236 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0165363 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0164766 |
| AEBP2 | AE binding protein 2 | 0.0163937 |
| CUX1 | cut-like homeobox 1 | 0.0163451 |
| RPS19 | ribosomal protein S19 | 0.0158986 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0158415 |
| SVIL | supervillin | 0.0156382 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0155976 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0154974 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.015495 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0153402 |
| KIAA0825 | KIAA0825 | 0.015129 |
| SQSTM1 | sequestosome 1 | 0.0146518 |
| RGS2 | regulator of G-protein signaling 2 | 0.0145917 |
| CDH13 | cadherin 13 | 0.0145817 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0145704 |
| RPS3 | ribosomal protein S3 | 0.0144668 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0142391 |
| RPL37 | ribosomal protein L37 | 0.0137384 |
| PCDH15 | protocadherin-related 15 | 0.0135795 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0133523 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0133054 |
| EPHA4 | EPH receptor A4 | 0.0131452 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0130732 |
| GPHN | gephyrin | 0.0128369 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0127986 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0126536 |
| RPL7A | ribosomal protein L7a | 0.0126028 |
| ATXN1 | ataxin 1 | 0.0125692 |
| RPL27 | ribosomal protein L27 | 0.0125457 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0125153 |
| RPS27 | ribosomal protein S27 | 0.0125042 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.12866 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.125867 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.122152 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0865224 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0807742 |
| TXNRD1 | thioredoxin reductase 1 | -0.0741689 |
| TMSB10 | thymosin beta 10 | -0.059348 |
| ASPH | aspartate beta-hydroxylase | -0.0578705 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0542337 |
| RTN4 | reticulon 4 | -0.0541893 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0509574 |
| GDA | guanine deaminase | -0.0456358 |
| CANX | calnexin | -0.0424468 |
| NEK7 | NIMA-related kinase 7 | -0.0411409 |
| PGK1 | phosphoglycerate kinase 1 | -0.0393665 |
| EFNA5 | ephrin-A5 | -0.0371145 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0370675 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0365637 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0365445 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0356271 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0341676 |
| UBC | ubiquitin C | -0.0336816 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0332715 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.033019 |
| PTMA | prothymosin, alpha | -0.0328517 |
| OGA | O-GlcNAcase | -0.0323318 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0310403 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0309884 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0307723 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0307689 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0307507 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.029605 |
| SPAG9 | sperm associated antigen 9 | -0.0293326 |
| TNPO1 | transportin 1 | -0.0288449 |
| VIM | vimentin | -0.0275032 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0273589 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0270274 |
| FLNB | filamin B, beta | -0.0264711 |
| RAI1 | retinoic acid induced 1 | -0.0245761 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0244934 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0242815 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0241913 |
| MYOF | myoferlin | -0.0237704 |
| ENO1 | enolase 1, (alpha) | -0.0235934 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0235899 |
| ENAH | enabled homolog (Drosophila) | -0.0235211 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0234284 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0233251 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0233014 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0228327 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0228241 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0226146 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0225865 |
| SRGN | serglycin | -0.0225084 |
| CD109 | CD109 molecule | -0.0222783 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0220661 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0215419 |
| NRCAM | neuronal cell adhesion molecule | -0.021537 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0215347 |
| LDHA | lactate dehydrogenase A | -0.0214552 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.021366 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0213604 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.020748 |
| PTGR1 | prostaglandin reductase 1 | -0.0206833 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0206311 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0204622 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0201102 |
| PCBP2 | poly(rC) binding protein 2 | -0.0198916 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0195689 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0195197 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0195194 |
| ATP13A3 | ATPase type 13A3 | -0.0193661 |
| BMERB1 | bMERB domain containing 1 | -0.0192985 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0192488 |
| USP3 | ubiquitin specific peptidase 3 | -0.0191109 |
| S100A6 | S100 calcium binding protein A6 | -0.0190519 |
| GOLGA4 | golgin A4 | -0.0189925 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0188356 |
| MFF | mitochondrial fission factor | -0.0187889 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0186981 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0185243 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.018452 |
| CTSC | cathepsin C | -0.0184459 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0182362 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0182341 |
| RBM39 | RNA binding motif protein 39 | -0.0177843 |
| WDR45B | WD repeat domain 45B | -0.0175957 |
| KPNB1 | karyopherin (importin) beta 1 | -0.017486 |
| MAP1B | microtubule-associated protein 1B | -0.0171984 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0171425 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0168964 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0168066 |
| CALU | calumenin | -0.0167863 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0166746 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0162012 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0161538 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0160822 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0159062 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0158098 |
| NUP58 | nucleoporin 58 | -0.0157849 |
