| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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119 genes differentially expressed following the Irinotecan_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.156297 |
| DST | dystonin | 0.140016 |
| SLC38A2 | solute carrier family 38, member 2 | 0.131726 |
| FLNB | filamin B, beta | 0.126789 |
| TMSB10 | thymosin beta 10 | 0.120929 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.120754 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.118517 |
| SYT1 | synaptotagmin I | 0.114468 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.107524 |
| MYO1E | myosin IE | 0.105561 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.102819 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0933959 |
| ASPH | aspartate beta-hydroxylase | 0.0926775 |
| OXSR1 | oxidative stress responsive 1 | 0.0908643 |
| FMN1 | formin 1 | 0.0794744 |
| COPA | coatomer protein complex, subunit alpha | 0.0788068 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0786792 |
| PARD3 | par-3 family cell polarity regulator | 0.0751639 |
| MED13 | mediator complex subunit 13 | 0.0734224 |
| TOP1 | topoisomerase (DNA) I | 0.0707052 |
| EZR | ezrin | 0.0705208 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0698019 |
| RPS6 | ribosomal protein S6 | 0.0696402 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0645126 |
| FTL | ferritin, light polypeptide | 0.0639947 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0632299 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0598148 |
| NDRG1 | N-myc downstream regulated 1 | 0.0580751 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0497985 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.049677 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0489285 |
| RPL37A | ribosomal protein L37a | 0.0468969 |
| EFNA5 | ephrin-A5 | 0.0465877 |
| BPTF | bromodomain PHD finger transcription factor | 0.0463237 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0435359 |
| ERBIN | erbb2 interacting protein | 0.0435027 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0413768 |
| ITGA6 | integrin, alpha 6 | 0.0405065 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0394714 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0393964 |
| WWOX | WW domain containing oxidoreductase | 0.0385784 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0328773 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0327571 |
| LMO7 | LIM domain 7 | 0.0319479 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0312565 |
| RPS12 | ribosomal protein S12 | 0.0302763 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0273814 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0272784 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.023612 |
| COL5A2 | collagen, type V, alpha 2 | 0.022843 |
| CD44 | CD44 molecule (Indian blood group) | 0.0226401 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0185337 |
| RPL35A | ribosomal protein L35a | 0.0165949 |
| RNF213 | ring finger protein 213 | 0.0154235 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0132155 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0123359 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0121855 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0112342 |
| LDHA | lactate dehydrogenase A | 0.00834695 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.00609623 |
| RPS27A | ribosomal protein S27a | 0.00558857 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00495085 |
| GPC6 | glypican 6 | 0.00152886 |
| PTMA | prothymosin, alpha | 2.12034E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMA4 | laminin, alpha 4 | -0.214935 |
| FN1 | fibronectin 1 | -0.180749 |
| EGFR | epidermal growth factor receptor | -0.162792 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.145062 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.14464 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.128758 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.120749 |
| VIM | vimentin | -0.114042 |
| SPAG9 | sperm associated antigen 9 | -0.113726 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.108111 |
| DSCAM | Down syndrome cell adhesion molecule | -0.106335 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.103926 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.10029 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0855058 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0811491 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0750448 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0743376 |
| YBX3 | Y box binding protein 3 | -0.0725838 |
| RPS3 | ribosomal protein S3 | -0.0714276 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0701018 |
| SBF2 | SET binding factor 2 | -0.0688859 |
| SLTM | SAFB-like, transcription modulator | -0.0676615 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0674799 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0647735 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0631131 |
| USP34 | ubiquitin specific peptidase 34 | -0.0601753 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0536973 |
| JMJD1C | jumonji domain containing 1C | -0.0534273 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0532725 |
| PKM | pyruvate kinase, muscle | -0.0529958 |
| MT2A | metallothionein 2A | -0.0506374 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0447073 |
| RIGI | RNA sensor RIG-I | -0.0438707 |
| PRKCA | protein kinase C, alpha | -0.0438113 |
| PTK2 | protein tyrosine kinase 2 | -0.0414498 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0385363 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0356339 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0307806 |
| RUNX1 | runt-related transcription factor 1 | -0.0273706 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0229771 |
| MYO6 | myosin VI | -0.0215761 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0206611 |
| CNKSR3 | CNKSR family member 3 | -0.0205298 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0203767 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0192943 |
| RPLP1 | ribosomal protein, large, P1 | -0.017043 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0144161 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0129603 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0119188 |
| TPM4 | tropomyosin 4 | -0.00935887 |
| ANO6 | anoctamin 6 | -0.00887381 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.00771871 |
| FMNL2 | formin-like 2 | -0.00132592 |
| RPS8 | ribosomal protein S8 | -0.0010825 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -9.78108E-4 |
