| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.116825 |
| COL11A1 | collagen, type XI, alpha 1 | 0.111208 |
| CADM2 | cell adhesion molecule 2 | 0.0959529 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0854101 |
| NTM | neurotrimin | 0.0837088 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0831526 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0772752 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0701802 |
| HDAC9 | histone deacetylase 9 | 0.0657393 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0600408 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0592706 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0570108 |
| DST | dystonin | 0.0505234 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0492056 |
| NCAM2 | neural cell adhesion molecule 2 | 0.048958 |
| PCDH9 | protocadherin 9 | 0.0485672 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.045705 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0427057 |
| PEG10 | paternally expressed 10 | 0.0422897 |
| SMYD3 | SET and MYND domain containing 3 | 0.0418848 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.041756 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0414533 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0407575 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0407364 |
| MEIS2 | Meis homeobox 2 | 0.0400925 |
| PCDH7 | protocadherin 7 | 0.0375336 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.037189 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0364191 |
| FOXP2 | forkhead box P2 | 0.0364068 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0347073 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0345904 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0327628 |
| CCDC102B | coiled-coil domain containing 102B | 0.0305193 |
| ITGAV | integrin, alpha V | 0.030127 |
| TENM3 | teneurin transmembrane protein 3 | 0.0296422 |
| SIK2 | salt-inducible kinase 2 | 0.028918 |
| LYST | lysosomal trafficking regulator | 0.0282025 |
| H1-0 | H1.0 linker histone | 0.0281962 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0276344 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0275566 |
| PRKD1 | protein kinase D1 | 0.0273067 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.027302 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0269576 |
| RASAL2 | RAS protein activator like 2 | 0.0265566 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0259542 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0248163 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0247495 |
| SYT1 | synaptotagmin I | 0.0246334 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0244594 |
| COL5A2 | collagen, type V, alpha 2 | 0.024396 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0234521 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0232948 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0231014 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0229679 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0228286 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0227044 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0223163 |
| TCF12 | transcription factor 12 | 0.0223054 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0221066 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0219437 |
| JMJD1C | jumonji domain containing 1C | 0.0210703 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0205542 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0200253 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0197976 |
| PLPP1 | phospholipid phosphatase 1 | 0.0197146 |
| DENND5B | DENN/MADD domain containing 5B | 0.0196994 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.019213 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0191031 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0189166 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0188131 |
| GPC3 | glypican 3 | 0.0187962 |
| NRG1 | neuregulin 1 | 0.0185841 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.018417 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0183372 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0182204 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0180073 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0179087 |
| FNIP1 | folliculin interacting protein 1 | 0.0177903 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0174987 |
| NEBL | nebulette | 0.0174433 |
| ZNF608 | zinc finger protein 608 | 0.0172817 |
| PROS1 | protein S (alpha) | 0.0169437 |
| NSD3 | nuclear receptor binding SET domain protein 3 | 0.016939 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0168987 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0166159 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0165028 |
| ZFHX4 | zinc finger homeobox 4 | 0.016447 |
| RIGI | RNA sensor RIG-I | 0.0162617 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0162361 |
| FRY | furry homolog (Drosophila) | 0.0162223 |
| AFAP1 | actin filament associated protein 1 | 0.0160799 |
| NBEAL1 | neurobeachin-like 1 | 0.0160668 |
| RPL3 | ribosomal protein L3 | 0.0160612 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0160367 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0158835 |
| CDH19 | cadherin 19, type 2 | 0.0157491 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 0.0155542 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0154207 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0154055 |
| ANXA1 | annexin A1 | 0.0153278 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.099213 |
| VIM | vimentin | -0.0848428 |
| PTMA | prothymosin, alpha | -0.0787329 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0742394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0532978 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0506262 |
| RPS16 | ribosomal protein S16 | -0.0502066 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0495883 |
| POTEF | POTE ankyrin domain family, member F | -0.0453855 |
| RPLP1 | ribosomal protein, large, P1 | -0.040758 |
| RPS8 | ribosomal protein S8 | -0.0400847 |
| RPL35A | ribosomal protein L35a | -0.0392079 |
| RPS27A | ribosomal protein S27a | -0.0374042 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0374036 |
| PHIP | pleckstrin homology domain interacting protein | -0.0362032 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0354283 |
| UPP1 | uridine phosphorylase 1 | -0.0353987 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0350668 |
| GNAS | GNAS complex locus | -0.0342799 |
| RPL31 | ribosomal protein L31 | -0.0340196 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0328282 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0325444 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0317418 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0306062 |
| RLF | rearranged L-myc fusion | -0.0300407 |
| FTL | ferritin, light polypeptide | -0.029492 |
| RPL37 | ribosomal protein L37 | -0.0287909 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0281558 |
| PFN1 | profilin 1 | -0.0262732 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0259241 |
| RPL5 | ribosomal protein L5 | -0.025801 |
| RPS12 | ribosomal protein S12 | -0.0248194 |
| RPL36A | ribosomal protein L36a | -0.0241601 |
| RPS13 | ribosomal protein S13 | -0.0240528 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0238807 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0237501 |
| TBC1D12 | TBC1 domain family, member 12 | -0.023465 |
| SRP54 | signal recognition particle 54kDa | -0.0233278 |
| RPLP2 | ribosomal protein, large, P2 | -0.0231989 |
| RPS3 | ribosomal protein S3 | -0.0227533 |
| ACTG1 | actin gamma 1 | -0.0226947 |
| RPS25 | ribosomal protein S25 | -0.0226246 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0224038 |
| ZNF292 | zinc finger protein 292 | -0.0222828 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0219886 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0216911 |
| RTN4 | reticulon 4 | -0.0216011 |
| QKI | QKI, KH domain containing, RNA binding | -0.0213323 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0210477 |
| ENAH | enabled homolog (Drosophila) | -0.0209233 |
| B2M | beta-2-microglobulin | -0.0209121 |
| MTF2 | metal response element binding transcription factor 2 | -0.0209066 |
| CCN2 | cellular communication network factor 2 | -0.0208433 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0207755 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0207576 |
| RPS24 | ribosomal protein S24 | -0.0207123 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0203931 |
| RPS6 | ribosomal protein S6 | -0.0202735 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0201859 |
| USP3 | ubiquitin specific peptidase 3 | -0.0201804 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0201363 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0200374 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0198151 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0197569 |
| RPL12 | ribosomal protein L12 | -0.0195879 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0194164 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0192874 |
| RPS27 | ribosomal protein S27 | -0.0191089 |
| RPL30 | ribosomal protein L30 | -0.019096 |
| RPS19 | ribosomal protein S19 | -0.0190721 |
| NOP58 | NOP58 ribonucleoprotein | -0.0189866 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0188704 |
| APOE | apolipoprotein E | -0.0187419 |
| RPL28 | ribosomal protein L28 | -0.0187227 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0185828 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0185633 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0182624 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0181943 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0181034 |
| MAP4 | microtubule-associated protein 4 | -0.0179706 |
| RPS29 | ribosomal protein S29 | -0.0178096 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.017805 |
| STAG2 | stromal antigen 2 | -0.0177632 |
| RPL9 | ribosomal protein L9 | -0.0175081 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0174678 |
| S100A10 | S100 calcium binding protein A10 | -0.0173612 |
| RPS10 | ribosomal protein S10 | -0.017307 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0172985 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0172664 |
| HMGA1 | high mobility group AT-hook 1 | -0.0167908 |
| RBM25 | RNA binding motif protein 25 | -0.0167556 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0167046 |
| RPL23 | ribosomal protein L23 | -0.0165616 |
| HMGB1 | high mobility group box 1 | -0.0165469 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0165116 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0164086 |
| RPL37A | ribosomal protein L37a | -0.016395 |
| SERF2 | small EDRK-rich factor 2 | -0.0162957 |
| ATXN2 | ataxin 2 | -0.0161006 |
| YY1 | YY1 transcription factor | -0.0160816 |
