| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.273183 |
| HDAC9 | histone deacetylase 9 | 0.162434 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.116225 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0990883 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0978686 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0955838 |
| PDGFC | platelet derived growth factor C | 0.0944915 |
| ZNF608 | zinc finger protein 608 | 0.0865156 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0799749 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0705138 |
| EZR | ezrin | 0.0695431 |
| JMJD1C | jumonji domain containing 1C | 0.0693854 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0647785 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0619439 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0600675 |
| RPS6 | ribosomal protein S6 | 0.059347 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0580585 |
| ANXA1 | annexin A1 | 0.0553355 |
| USP34 | ubiquitin specific peptidase 34 | 0.0540849 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0536469 |
| GPHN | gephyrin | 0.0512395 |
| ECT2 | epithelial cell transforming 2 | 0.0507492 |
| VMP1 | vacuole membrane protein 1 | 0.0498345 |
| MLIP | muscular LMNA-interacting protein | 0.0488757 |
| TJP1 | tight junction protein 1 | 0.0483707 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.048116 |
| MED13L | mediator complex subunit 13-like | 0.0467938 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.046449 |
| FOXP1 | forkhead box P1 | 0.0464445 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0454598 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.045237 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0446246 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0433484 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0428618 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0426057 |
| GLI3 | GLI family zinc finger 3 | 0.0418246 |
| YAP1 | Yes-associated protein 1 | 0.0416224 |
| METTL15 | methyltransferase like 15 | 0.0415432 |
| ZNF638 | zinc finger protein 638 | 0.041001 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0406762 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0400807 |
| FNIP1 | folliculin interacting protein 1 | 0.0398569 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0395288 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0394268 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0392711 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0390916 |
| CENPP | centromere protein P | 0.0390617 |
| TRIM24 | tripartite motif containing 24 | 0.0388966 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0380971 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0377608 |
| MACROD2 | MACRO domain containing 2 | 0.0376301 |
| BPTF | bromodomain PHD finger transcription factor | 0.0369251 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.036743 |
| BRD2 | bromodomain containing 2 | 0.0366671 |
| ZNF292 | zinc finger protein 292 | 0.0357438 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0356995 |
| PCM1 | pericentriolar material 1 | 0.0355755 |
| RBM39 | RNA binding motif protein 39 | 0.0350154 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0348995 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0345181 |
| DIAPH3 | diaphanous-related formin 3 | 0.0341897 |
| VIM | vimentin | 0.0341787 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0339492 |
| RB1 | retinoblastoma 1 | 0.0335319 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0330887 |
| SGMS1 | sphingomyelin synthase 1 | 0.032667 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0321083 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0321032 |
| SPAG9 | sperm associated antigen 9 | 0.031766 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0314792 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0313722 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0307991 |
| TCF12 | transcription factor 12 | 0.0304069 |
| PTEN | phosphatase and tensin homolog | 0.0303106 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0302953 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0300996 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0299063 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0297579 |
| NF1 | neurofibromin 1 | 0.029677 |
| RPL3 | ribosomal protein L3 | 0.0291783 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0290137 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0289111 |
| MED13 | mediator complex subunit 13 | 0.0288448 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0288087 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0287856 |
| RAB10 | RAB10, member RAS oncogene family | 0.0286798 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286785 |
| CRY1 | cryptochrome circadian clock 1 | 0.0283764 |
| DST | dystonin | 0.0281303 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0281057 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0280844 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0278376 |
| EGFR | epidermal growth factor receptor | 0.0277637 |
| RRM2 | ribonucleotide reductase M2 | 0.0276066 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0275498 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0275057 |
| RBM25 | RNA binding motif protein 25 | 0.0274901 |
| DENND4A | DENN/MADD domain containing 4A | 0.0274132 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0272755 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0271413 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.156173 |
| BMP10 | bone morphogenetic protein 10 | -0.14523 |
| PTMA | prothymosin, alpha | -0.116207 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106062 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100935 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0983103 |
| AHNAK | AHNAK nucleoprotein | -0.095248 |
| ACTG1 | actin gamma 1 | -0.0684624 |
| TMSB4X | thymosin beta 4, X-linked | -0.0611815 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0559251 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0539245 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0515166 |
| CCND1 | cyclin D1 | -0.0514471 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0496305 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0491428 |
| S100A6 | S100 calcium binding protein A6 | -0.0488903 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0481539 |
| NEBL | nebulette | -0.046637 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0454601 |
| S100A4 | S100 calcium binding protein A4 | -0.0433734 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0425341 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0415853 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0415056 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0380488 |
| HJURP | Holliday junction recognition protein | -0.0376025 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0353291 |
| LDHA | lactate dehydrogenase A | -0.0352401 |
| BMP2K | BMP2 inducible kinase | -0.0350506 |
| PDE7B | phosphodiesterase 7B | -0.0341165 |
| PYGB | phosphorylase, glycogen; brain | -0.0338592 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0326216 |
| BCOR | BCL6 corepressor | -0.0314739 |
| RPL34 | ribosomal protein L34 | -0.0312299 |
| EVI5 | ecotropic viral integration site 5 | -0.0298559 |
| CANX | calnexin | -0.029641 |
| SQSTM1 | sequestosome 1 | -0.0292863 |
| NBEA | neurobeachin | -0.0290709 |
| FLNB | filamin B, beta | -0.0283476 |
| TPM4 | tropomyosin 4 | -0.0278094 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0272961 |
| RPL12 | ribosomal protein L12 | -0.0272797 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0265513 |
| DENND1A | DENN/MADD domain containing 1A | -0.0264681 |
| RPL13A | ribosomal protein L13a | -0.0261143 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0252647 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0248047 |
| NAV2 | neuron navigator 2 | -0.0234473 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0233679 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023355 |
| MKI67 | marker of proliferation Ki-67 | -0.0231696 |
| RPL4 | ribosomal protein L4 | -0.0229932 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0229526 |
| DUSP4 | dual specificity phosphatase 4 | -0.0226801 |
| RPS24 | ribosomal protein S24 | -0.0223583 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.0222989 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0220402 |
| RPLP1 | ribosomal protein, large, P1 | -0.0208813 |
| PRSS23 | protease, serine, 23 | -0.0202345 |
| ZNF106 | zinc finger protein 106 | -0.0199543 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0199198 |
| CAVIN2 | caveolae associated protein 2 | -0.0195133 |
| RPS28 | ribosomal protein S28 | -0.0193797 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0191652 |
| CENATAC | centrosomal AT-AC splicing factor | -0.019028 |
| USP3 | ubiquitin specific peptidase 3 | -0.0187593 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0187521 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0186502 |
| EMP3 | epithelial membrane protein 3 | -0.0184892 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0184808 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0184492 |
| ENO1 | enolase 1, (alpha) | -0.0182684 |
| RPLP0 | ribosomal protein, large, P0 | -0.0180406 |
| CCNI | cyclin I | -0.018022 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0179452 |
| CSF2RA | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | -0.0178414 |
| RASA3 | RAS p21 protein activator 3 | -0.0175163 |
| RPL26 | ribosomal protein L26 | -0.0175071 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0174057 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | -0.0173904 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0171525 |
| PGK1 | phosphoglycerate kinase 1 | -0.0169862 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0169145 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0168399 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0164523 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0163186 |
| MYOF | myoferlin | -0.0162714 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | -0.0162365 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.0161518 |
| NFIA | nuclear factor I/A | -0.0161249 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0160984 |
| BSG | basigin (Ok blood group) | -0.0158803 |
| RPL35A | ribosomal protein L35a | -0.0158511 |
| PLXNA2 | plexin A2 | -0.0158122 |
| PDE10A | phosphodiesterase 10A | -0.0157977 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0155371 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.0154012 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0153672 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0153491 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0151555 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.0150771 |
