| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.155434 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.107322 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0876936 |
| GLIS3 | GLIS family zinc finger 3 | 0.082299 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0822035 |
| GOLGB1 | golgin B1 | 0.0792296 |
| RPS12 | ribosomal protein S12 | 0.0769133 |
| KYNU | kynureninase | 0.0730214 |
| INTS6 | integrator complex subunit 6 | 0.0688295 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0671881 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0657312 |
| HMGA2 | high mobility group AT-hook 2 | 0.0647161 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0633617 |
| ASPH | aspartate beta-hydroxylase | 0.062393 |
| SQSTM1 | sequestosome 1 | 0.0553368 |
| ATXN1 | ataxin 1 | 0.0549713 |
| RND3 | Rho family GTPase 3 | 0.0547486 |
| SFTPA2 | surfactant protein A2 | 0.0510571 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.050539 |
| SMAD3 | SMAD family member 3 | 0.0495775 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0493733 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0486248 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.047815 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0476599 |
| BICC1 | BicC family RNA binding protein 1 | 0.0473733 |
| FNIP1 | folliculin interacting protein 1 | 0.0454419 |
| DST | dystonin | 0.0437394 |
| RPL37A | ribosomal protein L37a | 0.0436628 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0411005 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0393755 |
| RPS2 | ribosomal protein S2 | 0.0393391 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.039257 |
| VMP1 | vacuole membrane protein 1 | 0.0391656 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0389706 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0384989 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0383312 |
| AHNAK | AHNAK nucleoprotein | 0.0381957 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0380609 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0375856 |
| BRD2 | bromodomain containing 2 | 0.0372212 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0371738 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0371383 |
| TLE4 | transducin-like enhancer of split 4 | 0.0366363 |
| DUSP10 | dual specificity phosphatase 10 | 0.0366023 |
| RPS6 | ribosomal protein S6 | 0.0365548 |
| VEGFA | vascular endothelial growth factor A | 0.0349271 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0348268 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0347633 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0341271 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0338602 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0337058 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0329563 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0328379 |
| PHF3 | PHD finger protein 3 | 0.0325649 |
| EGFR | epidermal growth factor receptor | 0.0318423 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0316352 |
| TUT7 | terminal uridylyl transferase 7 | 0.029316 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0289723 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0288964 |
| OPTN | optineurin | 0.0284332 |
| AHR | aryl hydrocarbon receptor | 0.0279993 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.02772 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0274712 |
| SVIL | supervillin | 0.0273248 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.026847 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0265869 |
| RPS8 | ribosomal protein S8 | 0.0264762 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0263712 |
| BPTF | bromodomain PHD finger transcription factor | 0.0262566 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0258723 |
| RPS17 | ribosomal protein S17 | 0.0255761 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0255657 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0254367 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.02512 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0250516 |
| STC1 | stanniocalcin 1 | 0.0249953 |
| RPS3 | ribosomal protein S3 | 0.024699 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0246443 |
| ZNF608 | zinc finger protein 608 | 0.0245929 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.024059 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0240382 |
| USP53 | ubiquitin specific peptidase 53 | 0.0239525 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.023903 |
| HLA-E | major histocompatibility complex, class I, E | 0.0238194 |
| ARFGEF3 | ARFGEF family member 3 | 0.0237571 |
| TPM3 | tropomyosin 3 | 0.0237277 |
| FMNL2 | formin-like 2 | 0.0230575 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0230301 |
| TMF1 | TATA element modulatory factor 1 | 0.0229713 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0229043 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0228308 |
| MT2A | metallothionein 2A | 0.022813 |
| JMJD1C | jumonji domain containing 1C | 0.0226453 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0222015 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0221061 |
| EHBP1 | EH domain binding protein 1 | 0.0220342 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0220337 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0220291 |
| RASEF | RAS and EF-hand domain containing | 0.0219762 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0219434 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.181854 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.175153 |
| FN1 | fibronectin 1 | -0.173371 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.137415 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.134978 |
| PGK1 | phosphoglycerate kinase 1 | -0.117575 |
| CADM1 | cell adhesion molecule 1 | -0.0964155 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0858244 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0826372 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0813961 |
| IER3 | immediate early response 3 | -0.0807272 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0800676 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0781549 |
| ZNF292 | zinc finger protein 292 | -0.0744511 |
| PTMA | prothymosin, alpha | -0.0738755 |
| FTL | ferritin, light polypeptide | -0.0732741 |
| TMSB10 | thymosin beta 10 | -0.072916 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0722984 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0716179 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0712617 |
| TPM4 | tropomyosin 4 | -0.0682275 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0661166 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0617703 |
| ATP13A3 | ATPase type 13A3 | -0.0603458 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0597446 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0535039 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.051208 |
| RPS24 | ribosomal protein S24 | -0.0508811 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0507551 |
| RTN4 | reticulon 4 | -0.050608 |
| TUBB | tubulin, beta class I | -0.049868 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0484878 |
| TMEM123 | transmembrane protein 123 | -0.0472616 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0454727 |
| ACTG1 | actin gamma 1 | -0.0445328 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0441475 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0436354 |
| WTAP | Wilms tumor 1 associated protein | -0.0434528 |
| GOLGA4 | golgin A4 | -0.0427566 |
| HELZ | helicase with zinc finger | -0.0427082 |
| SBF2 | SET binding factor 2 | -0.0426148 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0419945 |
| ANLN | anillin, actin binding protein | -0.0419195 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0408458 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.04047 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0404289 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0399456 |
| GNAS | GNAS complex locus | -0.0396608 |
| TKT | transketolase | -0.0396098 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0395516 |
| EGR1 | early growth response 1 | -0.0392331 |
| TFG | TRK-fused gene | -0.0385001 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0383681 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0380653 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0378941 |
| CTSD | cathepsin D | -0.0376625 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0375779 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0372894 |
| HMGA1 | high mobility group AT-hook 1 | -0.0372402 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0371685 |
| SPAG9 | sperm associated antigen 9 | -0.0371639 |
| POTEF | POTE ankyrin domain family, member F | -0.0369469 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0368211 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0362942 |
| QKI | QKI, KH domain containing, RNA binding | -0.0359053 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0354255 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0352451 |
| RPL23 | ribosomal protein L23 | -0.0349657 |
| WDR45B | WD repeat domain 45B | -0.0349433 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0347795 |
| SEPTIN7 | septin 7 | -0.0346681 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0343231 |
| ANXA2 | annexin A2 | -0.0342596 |
| TMEM41B | transmembrane protein 41B | -0.0335764 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0334811 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0334463 |
| RLF | rearranged L-myc fusion | -0.0330998 |
| RAI1 | retinoic acid induced 1 | -0.0322973 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0320968 |
| DIAPH2 | diaphanous-related formin 2 | -0.0317457 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0313933 |
| MAP4 | microtubule-associated protein 4 | -0.0311054 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0310686 |
| FAM162A | family with sequence similarity 162, member A | -0.0304721 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.030207 |
| ARF4 | ADP-ribosylation factor 4 | -0.0302025 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0301942 |
| USP3 | ubiquitin specific peptidase 3 | -0.0300194 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0293736 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0293714 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0285704 |
| RPL35A | ribosomal protein L35a | -0.0281625 |
| RBM39 | RNA binding motif protein 39 | -0.0281538 |
| COL1A1 | collagen, type I, alpha 1 | -0.0280982 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0276423 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0273201 |
| CANX | calnexin | -0.0268709 |
| DENND5A | DENN/MADD domain containing 5A | -0.026852 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0268378 |
| NUP58 | nucleoporin 58 | -0.0262666 |
