| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.098023 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0878671 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0842722 |
| GLIS3 | GLIS family zinc finger 3 | 0.0800772 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0792216 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0741565 |
| KYNU | kynureninase | 0.0730532 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0675267 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0617648 |
| VEGFC | vascular endothelial growth factor C | 0.0569354 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0563558 |
| FN1 | fibronectin 1 | 0.05505 |
| RUNX1 | runt-related transcription factor 1 | 0.0540532 |
| HMGA2 | high mobility group AT-hook 2 | 0.0529786 |
| CDH13 | cadherin 13 | 0.0526494 |
| COL5A1 | collagen, type V, alpha 1 | 0.0514709 |
| EGFR | epidermal growth factor receptor | 0.050247 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0497694 |
| PRELID2 | PRELI domain containing 2 | 0.0493174 |
| TNS3 | tensin 3 | 0.046794 |
| CD44 | CD44 molecule (Indian blood group) | 0.045922 |
| LOX | lysyl oxidase | 0.045252 |
| ATXN1 | ataxin 1 | 0.0445046 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.043743 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0432533 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0431894 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0429219 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0428057 |
| ANO6 | anoctamin 6 | 0.0427792 |
| IL6ST | interleukin 6 signal transducer | 0.0424973 |
| PRSS23 | protease, serine, 23 | 0.0423707 |
| AHNAK | AHNAK nucleoprotein | 0.0414875 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0410713 |
| NAV1 | neuron navigator 1 | 0.0409279 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0399193 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0381925 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.037955 |
| RAI14 | retinoic acid induced 14 | 0.0379258 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375378 |
| MAP1B | microtubule-associated protein 1B | 0.0374384 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0371092 |
| EXOC4 | exocyst complex component 4 | 0.036421 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0359114 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0356485 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0352946 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0352244 |
| NRXN3 | neurexin 3 | 0.0342259 |
| AHR | aryl hydrocarbon receptor | 0.0341945 |
| PRKCA | protein kinase C, alpha | 0.0341088 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0339931 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 0.0337984 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0331687 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0331267 |
| CDK6 | cyclin-dependent kinase 6 | 0.0330741 |
| DST | dystonin | 0.0329962 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0325806 |
| CALD1 | caldesmon 1 | 0.0321248 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0321197 |
| SMAD3 | SMAD family member 3 | 0.0316914 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0315741 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0311859 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.031139 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0307125 |
| VCL | vinculin | 0.0296232 |
| GOLGB1 | golgin B1 | 0.0295786 |
| ENO1 | enolase 1, (alpha) | 0.0295199 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0294362 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0293282 |
| IL6 | interleukin 6 | 0.0289956 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0289331 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0285153 |
| DSCAM | Down syndrome cell adhesion molecule | 0.02843 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0283026 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0282032 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0276499 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0276423 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0269062 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0264982 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0262437 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0262343 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0255515 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0255146 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.025331 |
| FNIP1 | folliculin interacting protein 1 | 0.0251115 |
| LOXL2 | lysyl oxidase-like 2 | 0.02495 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0247293 |
| ZNF638 | zinc finger protein 638 | 0.024526 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0242323 |
| STC1 | stanniocalcin 1 | 0.0239656 |
| CALU | calumenin | 0.0238858 |
| MYO9A | myosin IXA | 0.0234893 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0232702 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0230726 |
| MYO10 | myosin X | 0.0229776 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.0229189 |
| EFNA5 | ephrin-A5 | 0.0228893 |
| ATG7 | autophagy related 7 | 0.0227938 |
| RASAL2 | RAS protein activator like 2 | 0.0227811 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0227604 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.022735 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.153259 |
| TMSB10 | thymosin beta 10 | -0.10202 |
| FTL | ferritin, light polypeptide | -0.0832325 |
| MT2A | metallothionein 2A | -0.0698509 |
| VIM | vimentin | -0.0655682 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0546559 |
| PTMA | prothymosin, alpha | -0.0514106 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0424281 |
| NDRG1 | N-myc downstream regulated 1 | -0.0407472 |
| RPLP1 | ribosomal protein, large, P1 | -0.0370604 |
| S100A6 | S100 calcium binding protein A6 | -0.03353 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0333249 |
| RPL23 | ribosomal protein L23 | -0.0305474 |
| LMNA | lamin A/C | -0.0294271 |
| S100A9 | S100 calcium binding protein A9 | -0.028984 |
| RPL35A | ribosomal protein L35a | -0.0289002 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0275163 |
| H3-3B | H3.3 histone B | -0.0272208 |
| PDE10A | phosphodiesterase 10A | -0.0257096 |
| MT1X | metallothionein 1X | -0.0242056 |
| RPS5 | ribosomal protein S5 | -0.0234835 |
| RPS6 | ribosomal protein S6 | -0.0234441 |
| EGR1 | early growth response 1 | -0.0231879 |
| RPS24 | ribosomal protein S24 | -0.02314 |
| RPS19 | ribosomal protein S19 | -0.022507 |
| RPS3 | ribosomal protein S3 | -0.0218685 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0218114 |
| HLA-A | major histocompatibility complex, class I, A | -0.0215351 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0210835 |
| NOP58 | NOP58 ribonucleoprotein | -0.021011 |
| FOSL1 | FOS-like antigen 1 | -0.0204678 |
| RACK1 | receptor for activated C kinase 1 | -0.0203558 |
| RPS14 | ribosomal protein S14 | -0.0202375 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0201998 |
| PFN1 | profilin 1 | -0.0197273 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0196534 |
| FLOT1 | flotillin 1 | -0.0194007 |
| CSNK1E | casein kinase 1, epsilon | -0.019327 |
| POTEF | POTE ankyrin domain family, member F | -0.0192291 |
| RPL28 | ribosomal protein L28 | -0.0191401 |
| GPC6 | glypican 6 | -0.0190377 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0190033 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0189372 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0189014 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0188637 |
| RPL37A | ribosomal protein L37a | -0.0187311 |
| SPAG9 | sperm associated antigen 9 | -0.0186728 |
| RPS11 | ribosomal protein S11 | -0.0185034 |
| ACTN4 | actinin, alpha 4 | -0.0184965 |
| RPL11 | ribosomal protein L11 | -0.0182711 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0180506 |
| RPS8 | ribosomal protein S8 | -0.0178518 |
| WASF2 | WAS protein family, member 2 | -0.0174081 |
| PCBP2 | poly(rC) binding protein 2 | -0.0173645 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0173531 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0170986 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.017079 |
| USP36 | ubiquitin specific peptidase 36 | -0.0170496 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0169444 |
| RPLP2 | ribosomal protein, large, P2 | -0.0168467 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0166493 |
| CCNI | cyclin I | -0.0165668 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.016521 |
| PKM | pyruvate kinase, muscle | -0.0165138 |
| MATR3 | matrin 3 | -0.0161802 |
| PTN | pleiotrophin | -0.0159795 |
| GNAS | GNAS complex locus | -0.0159392 |
| NAV2 | neuron navigator 2 | -0.0159328 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0157149 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0154281 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0154117 |
| RPL38 | ribosomal protein L38 | -0.0152212 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | -0.0146813 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0146628 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0145882 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0145507 |
| GOLGA4 | golgin A4 | -0.0144602 |
| SRP54 | signal recognition particle 54kDa | -0.0144396 |
| RPS21 | ribosomal protein S21 | -0.0142868 |
| RPL12 | ribosomal protein L12 | -0.0141782 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.014127 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0140989 |
| RPL37 | ribosomal protein L37 | -0.0140198 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0139776 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0139759 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0138547 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | -0.0137997 |
| RNF216 | ring finger protein 216 | -0.0137797 |
| RPL26 | ribosomal protein L26 | -0.0136685 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0136614 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0135179 |
| RPS16 | ribosomal protein S16 | -0.0132568 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0131918 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0131413 |
| TXNRD1 | thioredoxin reductase 1 | -0.0131051 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0130887 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0129811 |
| ADM | adrenomedullin | -0.0129541 |
| RPN2 | ribophorin II | -0.0128998 |
| HLA-E | major histocompatibility complex, class I, E | -0.0127561 |
