| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.1022 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.082279 |
| SMAD3 | SMAD family member 3 | 0.0655397 |
| SMYD3 | SET and MYND domain containing 3 | 0.0628193 |
| CD44 | CD44 molecule (Indian blood group) | 0.0529969 |
| INTS6 | integrator complex subunit 6 | 0.0529907 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0512063 |
| DST | dystonin | 0.0471747 |
| AHNAK | AHNAK nucleoprotein | 0.0459718 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0419648 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0418548 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0395163 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0394227 |
| GOLGB1 | golgin B1 | 0.0386442 |
| IL6ST | interleukin 6 signal transducer | 0.0385529 |
| ASPH | aspartate beta-hydroxylase | 0.0371585 |
| HMGA2 | high mobility group AT-hook 2 | 0.0368015 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0366313 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0364106 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0357318 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0346053 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0341686 |
| SVIL | supervillin | 0.0327599 |
| FMNL2 | formin-like 2 | 0.0312936 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0312692 |
| SQSTM1 | sequestosome 1 | 0.0309938 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0299845 |
| NAV3 | neuron navigator 3 | 0.0299661 |
| HDAC9 | histone deacetylase 9 | 0.0299178 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0292393 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.029156 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0289778 |
| ANO6 | anoctamin 6 | 0.0288155 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.028407 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0282603 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0281569 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0268745 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0266525 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0265681 |
| ZNF638 | zinc finger protein 638 | 0.0261265 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0259794 |
| SIK2 | salt-inducible kinase 2 | 0.0258488 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0258237 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0254136 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0252942 |
| ATM | ATM serine/threonine kinase | 0.0248691 |
| TLE4 | transducin-like enhancer of split 4 | 0.0248303 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0241952 |
| AEBP2 | AE binding protein 2 | 0.0239855 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023818 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0236939 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0234458 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.0233601 |
| OXSR1 | oxidative stress responsive 1 | 0.023002 |
| EXOC4 | exocyst complex component 4 | 0.0228197 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.022588 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0224821 |
| SIK3 | SIK family kinase 3 | 0.0224712 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0224449 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.022207 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.022136 |
| JMJD1C | jumonji domain containing 1C | 0.0220573 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0214879 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.0212932 |
| EXT1 | exostosin glycosyltransferase 1 | 0.02109 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0209069 |
| NBEA | neurobeachin | 0.0205739 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0204112 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.0203998 |
| PLCB4 | phospholipase C, beta 4 | 0.0203594 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0201874 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0201381 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0197326 |
| RASAL2 | RAS protein activator like 2 | 0.0195655 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0192493 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0191332 |
| BRD2 | bromodomain containing 2 | 0.0190526 |
| PRR16 | proline rich 16 | 0.019006 |
| TXNIP | thioredoxin interacting protein | 0.0189877 |
| VMP1 | vacuole membrane protein 1 | 0.0189512 |
| SUMF1 | sulfatase modifying factor 1 | 0.0189023 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0187172 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0185945 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0184612 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.018459 |
| CAB39 | calcium binding protein 39 | 0.018414 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0182312 |
| CCNH | cyclin H | 0.0181919 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0181565 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0181365 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0180904 |
| ATXN1 | ataxin 1 | 0.0180851 |
| PHF3 | PHD finger protein 3 | 0.0178652 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0178644 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0177901 |
| WDR70 | WD repeat domain 70 | 0.0177355 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0175478 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0175282 |
| ZNF655 | zinc finger protein 655 | 0.0173911 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0172307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.290013 |
| VIM | vimentin | -0.116045 |
| TMSB10 | thymosin beta 10 | -0.0935862 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.073847 |
| PTMA | prothymosin, alpha | -0.072071 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0702796 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0679126 |
| MT2A | metallothionein 2A | -0.0665331 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0459765 |
| NDRG1 | N-myc downstream regulated 1 | -0.0434095 |
| SETD5 | SET domain containing 5 | -0.0427843 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0426245 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0426014 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0400957 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0392491 |
| RPLP1 | ribosomal protein, large, P1 | -0.0379869 |
| POTEF | POTE ankyrin domain family, member F | -0.0368057 |
| TPM4 | tropomyosin 4 | -0.0360968 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0360805 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0348932 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0347375 |
| ZNF292 | zinc finger protein 292 | -0.0334543 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0332429 |
| SPAG9 | sperm associated antigen 9 | -0.032636 |
| SNX14 | sorting nexin 14 | -0.0313836 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0311425 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0308933 |
| LDHA | lactate dehydrogenase A | -0.0308537 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.030617 |
| TMEM123 | transmembrane protein 123 | -0.0304894 |
| IGF2 | insulin-like growth factor 2 | -0.0304794 |
| SEPTIN7 | septin 7 | -0.0293832 |
| PKM | pyruvate kinase, muscle | -0.0286798 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.02863 |
| S100A9 | S100 calcium binding protein A9 | -0.0278027 |
| NUP58 | nucleoporin 58 | -0.0277691 |
| PFN1 | profilin 1 | -0.0275579 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0272442 |
| TBK1 | TANK-binding kinase 1 | -0.0268119 |
| SEC24A | SEC24 family member A | -0.0265334 |
| RPL23 | ribosomal protein L23 | -0.0264298 |
| GOLGA2 | golgin A2 | -0.026204 |
| COG5 | component of oligomeric golgi complex 5 | -0.0260642 |
| RNASEH2A | ribonuclease H2, subunit A | -0.0258029 |
| HELZ | helicase with zinc finger | -0.0257758 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0255769 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0255436 |
| BSG | basigin (Ok blood group) | -0.0246556 |
| IER3 | immediate early response 3 | -0.0239887 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0237923 |
| NGLY1 | N-glycanase 1 | -0.0237342 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0234339 |
| VDAC1 | voltage-dependent anion channel 1 | -0.023398 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.023313 |
| WASF2 | WAS protein family, member 2 | -0.0231427 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0228945 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.022377 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0223746 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0222443 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0221308 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0218592 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0217187 |
| ATP13A3 | ATPase type 13A3 | -0.0216337 |
| SGO2 | shugoshin 2 | -0.0214181 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0212356 |
| GLG1 | golgi glycoprotein 1 | -0.0212028 |
| CALU | calumenin | -0.0210068 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0208813 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0206898 |
| RPL32 | ribosomal protein L32 | -0.0205045 |
| INSIG1 | insulin induced gene 1 | -0.0204965 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0204362 |
| RAI1 | retinoic acid induced 1 | -0.0204175 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0203622 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0203193 |
| IKBIP | IKBKB interacting protein | -0.0199903 |
| RPLP0 | ribosomal protein, large, P0 | -0.0199494 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.0197401 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0197301 |
| RPS23 | ribosomal protein S23 | -0.0196626 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0195749 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0195562 |
| ZNF207 | zinc finger protein 207 | -0.0193982 |
| CCNI | cyclin I | -0.0193634 |
| WDR45B | WD repeat domain 45B | -0.0193321 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0192688 |
| DNER | delta/notch-like EGF repeat containing | -0.0192656 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0189948 |
| LDHB | lactate dehydrogenase B | -0.0189076 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0188675 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0188515 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0186652 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.018631 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0185881 |
| PDS5B | PDS5 cohesin associated factor B | -0.0185273 |
| PREPL | prolyl endopeptidase-like | -0.0184796 |
| RPL7 | ribosomal protein L7 | -0.018476 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0184601 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0184584 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.018435 |
