| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.149938 |
| ASPH | aspartate beta-hydroxylase | 0.0976719 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0912057 |
| HMGA2 | high mobility group AT-hook 2 | 0.075074 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0658246 |
| GLIS3 | GLIS family zinc finger 3 | 0.0643866 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0488935 |
| INTS6 | integrator complex subunit 6 | 0.0459949 |
| AEBP2 | AE binding protein 2 | 0.0443742 |
| EFNA5 | ephrin-A5 | 0.0441497 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0439396 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0398553 |
| RAI14 | retinoic acid induced 14 | 0.0386161 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0349053 |
| VCL | vinculin | 0.0331891 |
| RASAL2 | RAS protein activator like 2 | 0.03237 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.032346 |
| PALLD | palladin, cytoskeletal associated protein | 0.0309104 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0297858 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0295749 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0295072 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0269462 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0268356 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0268123 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0258529 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0256003 |
| LOXL2 | lysyl oxidase-like 2 | 0.0247215 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0247122 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0245514 |
| SYT1 | synaptotagmin I | 0.0245369 |
| NTN4 | netrin 4 | 0.0242143 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0241683 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0239325 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0238555 |
| TMEM156 | transmembrane protein 156 | 0.0233734 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0233663 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0230582 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0229774 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0221879 |
| RANBP17 | RAN binding protein 17 | 0.0221213 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0220331 |
| SVIL | supervillin | 0.0218876 |
| SFTPA2 | surfactant protein A2 | 0.0216557 |
| ATF6 | activating transcription factor 6 | 0.0215137 |
| IFI44L | interferon-induced protein 44-like | 0.0212867 |
| STC2 | stanniocalcin 2 | 0.0212798 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0212295 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0207355 |
| DST | dystonin | 0.0206657 |
| RIGI | RNA sensor RIG-I | 0.0205493 |
| SEPTIN9 | septin 9 | 0.0198106 |
| GOLGB1 | golgin B1 | 0.0195653 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0194877 |
| TNS3 | tensin 3 | 0.0194795 |
| PRKCA | protein kinase C, alpha | 0.0194644 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0191312 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0191119 |
| DUSP16 | dual specificity phosphatase 16 | 0.0190757 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0190509 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0190441 |
| EXOC4 | exocyst complex component 4 | 0.0189849 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.018953 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0188767 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0186805 |
| ABR | active BCR-related | 0.0186122 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0186091 |
| ATXN1 | ataxin 1 | 0.018477 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0184514 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0180613 |
| EGFR | epidermal growth factor receptor | 0.0180032 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0178941 |
| CTBP2 | C-terminal binding protein 2 | 0.017702 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.017687 |
| VEGFC | vascular endothelial growth factor C | 0.0176119 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0176108 |
| SMAD3 | SMAD family member 3 | 0.0175999 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0174873 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0173232 |
| MCL1 | myeloid cell leukemia 1 | 0.0169691 |
| GPATCH2L | G patch domain containing 2-like | 0.0168376 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0167939 |
| RAD51B | RAD51 paralog B | 0.0165887 |
| EHBP1 | EH domain binding protein 1 | 0.016571 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0165238 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0163299 |
| NBEA | neurobeachin | 0.0161973 |
| MLPH | melanophilin | 0.0161623 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0161613 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.016126 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0161142 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0160178 |
| NPAS2 | neuronal PAS domain protein 2 | 0.016016 |
| CCDC138 | coiled-coil domain containing 138 | 0.0160128 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0159519 |
| CUX1 | cut-like homeobox 1 | 0.015927 |
| AHNAK | AHNAK nucleoprotein | 0.0158537 |
| OXR1 | oxidation resistance 1 | 0.0158326 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0158303 |
| NXN | nucleoredoxin | 0.0157052 |
| FBN1 | fibrillin 1 | 0.0156992 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.367356 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.129492 |
| MT2A | metallothionein 2A | -0.109263 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.108121 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0958661 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0948527 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0918451 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0840119 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0828321 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0764772 |
| PTMA | prothymosin, alpha | -0.0763531 |
| NDRG1 | N-myc downstream regulated 1 | -0.0744429 |
| VIM | vimentin | -0.0744375 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0718695 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0682588 |
| FTL | ferritin, light polypeptide | -0.0621002 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0613705 |
| CANX | calnexin | -0.0536034 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0494988 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0494269 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0480463 |
| RNF145 | ring finger protein 145 | -0.0480245 |
| ZNF292 | zinc finger protein 292 | -0.0473946 |
| RTN4 | reticulon 4 | -0.0473202 |
| WDR45B | WD repeat domain 45B | -0.0458985 |
| SEPTIN7 | septin 7 | -0.0439091 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0436644 |
| CD109 | CD109 molecule | -0.0423596 |
| SPAG9 | sperm associated antigen 9 | -0.0407134 |
| NUP58 | nucleoporin 58 | -0.0406502 |
| TFG | TRK-fused gene | -0.0401587 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0399107 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0393288 |
| HELZ | helicase with zinc finger | -0.0391692 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0391319 |
| TMSB10 | thymosin beta 10 | -0.0390863 |
| S100A6 | S100 calcium binding protein A6 | -0.039076 |
| OGA | O-GlcNAcase | -0.0386914 |
| WAC | WW domain containing adaptor with coiled-coil | -0.038534 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0380925 |
| RPS6 | ribosomal protein S6 | -0.0379806 |
| RBM39 | RNA binding motif protein 39 | -0.0379756 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0372465 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0369523 |
| PGK1 | phosphoglycerate kinase 1 | -0.0366806 |
| COPA | coatomer protein complex, subunit alpha | -0.0364188 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0360632 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0357435 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.035484 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0350337 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0349258 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0347908 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0344294 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0325842 |
| CENPF | centromere protein F, 350/400kDa | -0.0321375 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0318209 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317919 |
| PCBP2 | poly(rC) binding protein 2 | -0.0313822 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0313411 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.031125 |
| NEK7 | NIMA-related kinase 7 | -0.0309579 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0308425 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0308315 |
| GOLGA4 | golgin A4 | -0.0307682 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.030701 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0304887 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0303787 |
| PKM | pyruvate kinase, muscle | -0.0300596 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0297238 |
| RNF24 | ring finger protein 24 | -0.029576 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0294674 |
| CALU | calumenin | -0.0289445 |
| HMGA1 | high mobility group AT-hook 1 | -0.0288391 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0286214 |
| RLF | rearranged L-myc fusion | -0.0283604 |
| RPLP1 | ribosomal protein, large, P1 | -0.0280036 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0279767 |
| CDC27 | cell division cycle 27 | -0.0278301 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0276762 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0275463 |
| RPL12 | ribosomal protein L12 | -0.027318 |
| ANLN | anillin, actin binding protein | -0.0272288 |
| INSIG2 | insulin induced gene 2 | -0.0270676 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0268813 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0265564 |
| XPO1 | exportin 1 | -0.0262849 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0259234 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0254645 |
| B2M | beta-2-microglobulin | -0.0254398 |
| RHEB | Ras homolog enriched in brain | -0.0253795 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0248374 |
| PELO | pelota homolog (Drosophila) | -0.024387 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0242611 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0242374 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0240536 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0240216 |
| RIOK3 | RIO kinase 3 | -0.0239729 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0239565 |
| FOSL1 | FOS-like antigen 1 | -0.0239477 |
| CCNL1 | cyclin L1 | -0.0239313 |
