Iron Overload Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0282193
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Genes

235 genes associated with the disease Iron Overload in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACO1 aconitase 1, soluble
ACVR1 activin A receptor, type I
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAS2 5'-aminolevulinate synthase 2
ALOX5 arachidonate 5-lipoxygenase
ALPP alkaline phosphatase, placental
APC adenomatous polyposis coli
APLN apelin
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ASRGL1 asparaginase like 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATRNL1 attractin-like 1
B2M beta-2-microglobulin
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP6 bone morphogenetic protein 6
BMPR1A bone morphogenetic protein receptor, type IA
BOLA2 bolA family member 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CASR calcium-sensing receptor
CAT catalase
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL27 chemokine (C-C motif) ligand 27
CCL4 chemokine (C-C motif) ligand 4
CCL4L1 chemokine (C-C motif) ligand 4-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CD38 CD38 molecule
CD59 CD59 molecule, complement regulatory protein
CD68 CD68 molecule
CDAN1 codanin 1
CHIT1 chitinase 1 (chitotriosidase)
CHMP2B charged multivesicular body protein 2B
COL11A2 collagen, type XI, alpha 2
COX2
CP ceruloplasmin (ferroxidase)
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRMP1 collapsin response mediator protein 1
CRP C-reactive protein, pentraxin-related
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL9 cullin 9
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYBRD1 cytochrome b reductase 1
DAPK2 death-associated protein kinase 2
DDIT3 DNA-damage-inducible transcript 3
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DENR density-regulated protein
DES desmin
DGUOK deoxyguanosine kinase
DMRT1 doublesex and mab-3 related transcription factor 1
DNM1L dynamin 1-like
EIF3A eukaryotic translation initiation factor 3, subunit A
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
EPO erythropoietin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM132B family with sequence similarity 132, member B
FANCC Fanconi anemia, complementation group C
FBXL5 F-box and leucine-rich repeat protein 5
FDXR ferredoxin reductase
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FTMT ferritin mitochondrial
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDF11 growth differentiation factor 11
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GGTLC1 gamma-glutamyltransferase light chain 1
GLRX5 glutaredoxin 5
GNPAT glyceronephosphate O-acyltransferase
GPER1 G protein-coupled estrogen receptor 1
GPI glucose-6-phosphate isomerase
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX4 glutathione peroxidase 4
GRAP2 GRB2-related adaptor protein 2
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HAMP hepcidin antimicrobial peptide
HAVCR1 hepatitis A virus cellular receptor 1
HBA1 hemoglobin, alpha 1
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HEPH hephaestin
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HHIPL2 HHIP-like 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HP haptoglobin
HPGDS hematopoietic prostaglandin D synthase
HPX hemopexin
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL6 interleukin 6
IREB2 iron-responsive element binding protein 2
IRS1 insulin receptor substrate 1
ISCU iron-sulfur cluster assembly enzyme
LCN2 lipocalin 2
LEP leptin
LOC102724197 inactive gamma-glutamyltranspeptidase 2-like
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MFF mitochondrial fission factor
MPO myeloperoxidase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC3A mucin 3A, cell surface associated
MUC7 mucin 7, secreted
MYD88 myeloid differentiation primary response 88
NAT10 N-acetyltransferase 10 (GCN5-related)
NCOA4 nuclear receptor coactivator 4
NEO1 neogenin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGF nerve growth factor (beta polypeptide)
NMBR neuromedin B receptor
NOD2 nucleotide-binding oligomerization domain containing 2
NOX4 NADPH oxidase 4
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
PAEP progestagen-associated endometrial protein
PARP1 poly (ADP-ribose) polymerase 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PDLIM3 PDZ and LIM domain 3
PER2 period circadian clock 2
PGF placental growth factor
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PINK1 PTEN induced putative kinase 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
PRDX5 peroxiredoxin 5
PREP prolyl endopeptidase
PRRX2 paired related homeobox 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
REN renin
REPS1 RALBP1 associated Eps domain containing 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPE ribulose-5-phosphate-3-epimerase
RUNX2 runt-related transcription factor 2
SCT secretin
SEC23B Sec23 homolog B (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SESN2 sestrin 2
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFXN1 sideroflexin 1
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC25A38 solute carrier family 25, member 38
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SLPI secretory leukocyte peptidase inhibitor
SMAD4 SMAD family member 4
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SPRR2A small proline-rich protein 2A
STAB2 stabilin 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SUCNR1 succinate receptor 1
SYP synaptophysin
TBPL1 TBP-like 1
TBXAS1 thromboxane A synthase 1 (platelet)
TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3
TERF2 telomeric repeat binding factor 2
TF transferrin
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UROD uroporphyrinogen decarboxylase
USF2 upstream transcription factor 2, c-fos interacting
UTRN utrophin
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45