Iron metabolism disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

246 genes co-occuring with the disease Iron metabolism disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HAMP hepcidin antimicrobial peptide 3.388
HFE hemochromatosis 3.23
HJV hemojuvelin BMP co-receptor 3.0
TFR2 transferrin receptor 2 2.984
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.969
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.905
TFRC transferrin receptor 2.845
CP ceruloplasmin (ferroxidase) 2.774
FTL ferritin, light polypeptide 2.681
PANK2 pantothenate kinase 2 2.616
TMPRSS6 transmembrane protease, serine 6 2.593
CYBRD1 cytochrome b reductase 1 2.577
IREB2 iron-responsive element binding protein 2 2.55
GPX4 glutathione peroxidase 4 2.436
STEAP3 STEAP family member 3, metalloreductase 2.428
FTH1 ferritin, heavy polypeptide 1 2.421
BMP6 bone morphogenetic protein 6 2.391
ACO1 aconitase 1, soluble 2.36
EPO erythropoietin 2.272
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.264
COASY CoA synthase 2.257
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.252
ERFE erythroferrone 2.244
C19ORF12 chromosome 19 open reading frame 12 2.238
FXN frataxin 2.159
NCOA4 nuclear receptor coactivator 4 2.159
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.158
FA2H fatty acid 2-hydroxylase 2.147
DCAF17 DDB1 and CUL4 associated factor 17 2.141
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.076
HMOX1 heme oxygenase 1 2.057
HEPH hephaestin 2.01
WDR45 WD repeat domain 45 2.008
ATP13A2 ATPase type 13A2 2.0
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 2.0
ACSL4 acyl-CoA synthetase long-chain family member 4 1.999
IL6 interleukin 6 1.99
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.979
MB myoglobin 1.975
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 1.969
ALB albumin 1.964
HP haptoglobin 1.958
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.943
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1.932
STEAP1 six transmembrane epithelial antigen of the prostate 1 1.921
LTF lactotransferrin 1.917
PANK1 pantothenate kinase 1 1.877
LPCAT3 lysophosphatidylcholine acyltransferase 3 1.869
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 1.832
HPX hemopexin 1.808
ATOX1 antioxidant 1 copper chaperone 1.804
CRP C-reactive protein, pentraxin-related 1.794
SLC46A1 solute carrier family 46 (folate transporter), member 1 1.793
SLC39A8 solute carrier family 39 (zinc transporter), member 8 1.787
ALAS2 5'-aminolevulinate synthase 2 1.783
PCBP1 poly(rC) binding protein 1 1.769
IL1B interleukin 1, beta 1.707
APP amyloid beta (A4) precursor protein 1.694
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.672
GPX6 glutathione peroxidase 6 1.658
ISCU iron-sulfur cluster assembly enzyme 1.652
GPX5 glutathione peroxidase 5 1.651
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.651
GPX8 glutathione peroxidase 8 (putative) 1.651
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 1.65
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.649
TNF tumor necrosis factor 1.646
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.644
PRTN3 proteinase 3 1.642
GPX7 glutathione peroxidase 7 1.636
GPX2 glutathione peroxidase 2 1.633
GPX3 glutathione peroxidase 3 1.63
INS insulin 1.603
SLC25A38 solute carrier family 25, member 38 1.597
MPO myeloperoxidase 1.581
GDF15 growth differentiation factor 15 1.573
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.569
EPAS1 endothelial PAS domain protein 1 1.556
NFE2L2 nuclear factor, erythroid 2-like 2 1.551
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.546
APOE apolipoprotein E 1.541
PXDNL peroxidasin-like 1.538
PXDN peroxidasin 1.536
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.523
NEO1 neogenin 1 1.513
SCARA5 scavenger receptor class A, member 5 1.51
ACO2 aconitase 2, mitochondrial 1.507
DNAH8 dynein, axonemal, heavy chain 8 1.494
REPS1 RALBP1 associated Eps domain containing 1 1.492
F2 coagulation factor II (thrombin) 1.489
IL1A interleukin 1, alpha 1.484
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.482
MT1E metallothionein 1E 1.467
CD163 CD163 molecule 1.458
GLRX5 glutaredoxin 5 1.458
FECH ferrochelatase 1.458
LCN2 lipocalin 2 1.446
KEAP1 kelch-like ECH-associated protein 1 1.443
CD68 CD68 molecule 1.442
COX17 COX17 cytochrome c oxidase copper chaperone 1.442
GTPBP2 GTP binding protein 2 1.442
HBE1 hemoglobin, epsilon 1 1.438
MON1A MON1 secretory trafficking family member A 1.432
LOX lysyl oxidase 1.43
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 1.428
TGFB1 transforming growth factor, beta 1 1.421
COPA coatomer protein complex, subunit alpha 1.42
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.417
ACTB actin, beta 1.401
FTMT ferritin mitochondrial 1.399
TP53 tumor protein p53 1.398
FBXL5 F-box and leucine-rich repeat protein 5 1.396
STEAP2 STEAP family member 2, metalloreductase 1.395
JAK2 Janus kinase 2 1.395
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 1.391
CPOX coproporphyrinogen oxidase 1.39
ACVR1 activin A receptor, type I 1.388
GCH1 GTP cyclohydrolase 1 1.384
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.378
IFNG interferon, gamma 1.371
PTH parathyroid hormone 1.368
CCS copper chaperone for superoxide dismutase 1.364
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.361
LIX1 Lix1 homolog (chicken) 1.353
B2M beta-2-microglobulin 1.349
BMPR1A bone morphogenetic protein receptor, type IA 1.344
HBB hemoglobin, beta 1.337
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.334
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.324
CD4 CD4 molecule 1.323
CD8A CD8a molecule 1.309
CCDC115 coiled-coil domain containing 115 1.305
UROD uroporphyrinogen decarboxylase 1.304
TGM2 transglutaminase 2 1.302
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.302
A2M alpha-2-macroglobulin 1.297
CD34 CD34 molecule 1.295
CKM creatine kinase, muscle 1.288
IL10 interleukin 10 1.288
IGF1 insulin-like growth factor 1 (somatomedin C) 1.286
DHODH dihydroorotate dehydrogenase (quinone) 1.271
EGLN2 egl-9 family hypoxia-inducible factor 2 1.271
CKB creatine kinase, brain 1.27
PAM peptidylglycine alpha-amidating monooxygenase 1.267
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.265
CKMT1B creatine kinase, mitochondrial 1B 1.264
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.259
SMAD4 SMAD family member 4 1.257
SOD1 superoxide dismutase 1, soluble 1.245
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.242
ALOX15 arachidonate 15-lipoxygenase 1.241
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.236
COMMD1 copper metabolism (Murr1) domain containing 1 1.235
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.231
SFTPB surfactant protein B 1.229
CD59 CD59 molecule, complement regulatory protein 1.225
FURIN furin (paired basic amino acid cleaving enzyme) 1.214
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.213
PCBP2 poly(rC) binding protein 2 1.21
NFS1 NFS1 cysteine desulfurase 1.208
SFTPC surfactant protein C 1.206
NPPB natriuretic peptide B 1.202
PSEN1 presenilin 1 1.196
TLR4 toll-like receptor 4 1.194
LRP1 low density lipoprotein receptor-related protein 1 1.194
MAPT microtubule-associated protein tau 1.194
FGF23 fibroblast growth factor 23 1.181
EGLN1 egl-9 family hypoxia-inducible factor 1 1.177
C3 complement component 3 1.176
NFE2 nuclear factor, erythroid 2 1.176
IFNA1 interferon, alpha 1 1.174
SPTA1 spectrin, alpha, erythrocytic 1 1.173
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.169
EGLN3 egl-9 family hypoxia-inducible factor 3 1.167
CDAN1 codanin 1 1.165
SFXN1 sideroflexin 1 1.165
NPC1 Niemann-Pick disease, type C1 1.16
GATA1 GATA binding protein 1 (globin transcription factor 1) 1.154
PANK3 pantothenate kinase 3 1.15
PINK1 PTEN induced putative kinase 1 1.149
ACE angiotensin I converting enzyme 1.149
F3 coagulation factor III (thromboplastin, tissue factor) 1.147
PKM pyruvate kinase, muscle 1.146
HMOX2 heme oxygenase 2 1.142
LRP2 low density lipoprotein receptor-related protein 2 1.141
LYRM4 LYR motif containing 4 1.139
ASCL4 achaete-scute family bHLH transcription factor 4 1.136
EMC2 ER membrane protein complex subunit 2 1.132
OTUD3 OTU deubiquitinase 3 1.131
RNF217 ring finger protein 217 1.131
AFP alpha-fetoprotein 1.13
TWSG1 twisted gastrulation BMP signaling modulator 1 1.128
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 1.127
ACSF2 acyl-CoA synthetase family member 2 1.126
TH tyrosine hydroxylase 1.125
ALAD aminolevulinate dehydratase 1.122
GSR glutathione reductase 1.119
SLC31A1 solute carrier family 31 (copper transporter), member 1 1.119
GYPA glycophorin A (MNS blood group) 1.109
FDX2 ferredoxin 2 1.101
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.099
RPE65 retinal pigment epithelium-specific protein 65kDa 1.098
OR2T3 olfactory receptor, family 2, subfamily T, member 3 1.096
ALAS1 5'-aminolevulinate synthase 1 1.092
HLA-A major histocompatibility complex, class I, A 1.092
SMAD9 SMAD family member 9 1.092
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.092
IL2 interleukin 2 1.091
G6PD glucose-6-phosphate dehydrogenase 1.089
TYR tyrosinase 1.074
CYCS cytochrome c, somatic 1.067
COX11 COX11 cytochrome c oxidase copper chaperone 1.066
SEC23B Sec23 homolog B (S. cerevisiae) 1.064
EPOR erythropoietin receptor 1.061
BMP2 bone morphogenetic protein 2 1.061
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.06
GFAP glial fibrillary acidic protein 1.06
CYB561 cytochrome b561 1.059
TBX4 T-box 4 1.058
SAMD1 sterile alpha motif domain containing 1 1.058
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.057
KLF1 Kruppel-like factor 1 (erythroid) 1.055
EIF5B eukaryotic translation initiation factor 5B 1.049
VDAC2 voltage-dependent anion channel 2 1.046
NKX2-1 NK2 homeobox 1 1.044
GLS2 glutaminase 2 (liver, mitochondrial) 1.044
ISCA1 iron-sulfur cluster assembly 1 1.043
GCLC glutamate-cysteine ligase, catalytic subunit 1.036
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 1.035
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.034
CXCL8 chemokine (C-X-C motif) ligand 8 1.032
AIF1 allograft inflammatory factor 1 1.03
BMP10 bone morphogenetic protein 10 1.023
TMEM199 transmembrane protein 199 1.021
CCL2 chemokine (C-C motif) ligand 2 1.021
RPL8 ribosomal protein L8 1.016
PRNP prion protein 1.013
GDF2 growth differentiation factor 2 1.013
NPC2 Niemann-Pick disease, type C2 1.012
POMC proopiomelanocortin 1.011
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.01
SCO1 SCO1 cytochrome c oxidase assembly protein 1.01
CCK cholecystokinin 1.01
PRKN parkin RBR E3 ubiquitin protein ligase 1.01
ELN elastin 1.007
NOX4 NADPH oxidase 4 1.001