Isocorydine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Isocorydine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.195496
PLAT plasminogen activator, tissue 0.164167
MT2A metallothionein 2A 0.110594
TPM3 tropomyosin 3 0.109938
CD44 CD44 molecule (Indian blood group) 0.106472
HLA-B major histocompatibility complex, class I, B 0.0971907
CALR calreticulin 0.0898259
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0792859
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0761856
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0759034
SEPTIN9 septin 9 0.073898
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0732265
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0715737
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0714165
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.071308
MYH9 myosin, heavy chain 9, non-muscle 0.0688128
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0671769
FLNB filamin B, beta 0.0654803
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.064631
KLF6 Kruppel-like factor 6 0.0609066
FLNA filamin A, alpha 0.059038
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0584802
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0561772
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0554756
AHNAK2 AHNAK nucleoprotein 2 0.0532118
MSN moesin 0.0454581
ANKRD11 ankyrin repeat domain 11 0.0453334
MPRIP myosin phosphatase Rho interacting protein 0.0442599
MT1X metallothionein 1X 0.0434398
MKI67 marker of proliferation Ki-67 0.0433257
COL3A1 collagen, type III, alpha 1 0.0429678
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0403735
CD99 CD99 molecule 0.0402735
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0377995
NCOR2 nuclear receptor corepressor 2 0.0374252
MYADM myeloid-associated differentiation marker 0.0373952
CD59 CD59 molecule, complement regulatory protein 0.036948
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.036799
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0367904
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0362742
EEF2 eukaryotic translation elongation factor 2 0.0361593
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0357614
THBS2 thrombospondin 2 0.0356165
GANAB glucosidase, alpha; neutral AB 0.0347674
SMC4 structural maintenance of chromosomes 4 0.0344929
ANLN anillin, actin binding protein 0.0341348
DCLK2 doublecortin-like kinase 2 0.0331799
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0322117
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.03131
RPL26 ribosomal protein L26 0.0312784
FOSL1 FOS-like antigen 1 0.0310345
PLEC plectin 0.0310269
HDAC9 histone deacetylase 9 0.030946
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0308861
EGR1 early growth response 1 0.030839
ENO1 enolase 1, (alpha) 0.0307821
PFN1 profilin 1 0.0307214
BCL2L1 BCL2-like 1 0.0303002
RTN4 reticulon 4 0.0302822
IFI6 interferon, alpha-inducible protein 6 0.0296289
COL5A1 collagen, type V, alpha 1 0.0293527
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0292907
BCAR3 breast cancer anti-estrogen resistance 3 0.0285482
PPARD peroxisome proliferator-activated receptor delta 0.0283651
CALU calumenin 0.027864
SMAD3 SMAD family member 3 0.0277528
ZMIZ1 zinc finger, MIZ-type containing 1 0.0275213
SHB Src homology 2 domain containing adaptor protein B 0.0267021
EXT1 exostosin glycosyltransferase 1 0.0265869
ADAM19 ADAM metallopeptidase domain 19 0.026532
PRRC2C proline-rich coiled-coil 2C 0.0260786
DOCK5 dedicator of cytokinesis 5 0.0260632
EZR ezrin 0.0259769
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0258886
GSE1 Gse1 coiled-coil protein 0.0258837
LAMB1 laminin, beta 1 0.025682
RPS2 ribosomal protein S2 0.0255374
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0254073
ANXA2 annexin A2 0.0252274
SET SET nuclear proto-oncogene 0.0247796
DNMBP dynamin binding protein 0.0246723
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0245016
ASPH aspartate beta-hydroxylase 0.0244165
FAT1 FAT atypical cadherin 1 0.0244107
NFE2L1 nuclear factor, erythroid 2-like 1 0.024283
NAV2 neuron navigator 2 0.0242771
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238642
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0235001
LDHA lactate dehydrogenase A 0.0234687
VAV2 vav 2 guanine nucleotide exchange factor 0.023383
RPS3 ribosomal protein S3 0.0232874
EGFR epidermal growth factor receptor 0.0231369
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0226592
L1CAM L1 cell adhesion molecule 0.0223621
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0222765
SON SON DNA binding protein 0.0221492
AFDN afadin, adherens junction formation factor 0.0221425
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.021749
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0216637
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0216588

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.196316
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.131944
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.121104
ABI3BP ABI family, member 3 (NESH) binding protein -0.109659
FBN1 fibrillin 1 -0.108458
AHNAK AHNAK nucleoprotein -0.0888979
PTMA prothymosin, alpha -0.0862106
VIM vimentin -0.0856783
COL8A1 collagen, type VIII, alpha 1 -0.0793013
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0788053
SAMD9 sterile alpha motif domain containing 9 -0.0781783
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0768353
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0753211
SOD2 superoxide dismutase 2, mitochondrial -0.071336
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0698643
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0652726
ZBTB20 zinc finger and BTB domain containing 20 -0.0651731
FTL ferritin, light polypeptide -0.0650753
DLG1 discs, large homolog 1 (Drosophila) -0.065023
PKM pyruvate kinase, muscle -0.0617786
COL1A2 collagen, type I, alpha 2 -0.0604213
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0604186
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0586814
RIGI RNA sensor RIG-I -0.0563706
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0525241
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0514925
NDRG1 N-myc downstream regulated 1 -0.0506253
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.049655
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0474491
CCND1 cyclin D1 -0.0469937
S100A6 S100 calcium binding protein A6 -0.0468587
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0464676
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.045815
AUTS2 autism susceptibility candidate 2 -0.0448773
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0447571
SUCNR1 succinate receptor 1 -0.044197
SP100 SP100 nuclear antigen -0.0434493
MYOF myoferlin -0.043274
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0417015
TTC3 tetratricopeptide repeat domain 3 -0.0414687
FN1 fibronectin 1 -0.0393944
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0390603
RPLP1 ribosomal protein, large, P1 -0.0363218
FNDC3A fibronectin type III domain containing 3A -0.0354779
TAGLN2 transgelin 2 -0.0351668
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0342752
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0342233
SORBS2 sorbin and SH3 domain containing 2 -0.0335584
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0332024
IFIH1 interferon induced with helicase C domain 1 -0.033161
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.032969
CSTB cystatin B (stefin B) -0.0326928
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0323345
MMP12 matrix metallopeptidase 12 -0.0322137
CDK6 cyclin-dependent kinase 6 -0.0317621
MSI2 musashi RNA-binding protein 2 -0.0314126
SOX9 SRY (sex determining region Y)-box 9 -0.0310352
HSPB1 heat shock 27kDa protein 1 -0.0300861
PDE4D phosphodiesterase 4D, cAMP-specific -0.0287577
AEBP2 AE binding protein 2 -0.0281526
UBC ubiquitin C -0.0280149
GNAS GNAS complex locus -0.0279898
SEPTIN7 septin 7 -0.0279634
INSIG1 insulin induced gene 1 -0.0279165
FSTL1 follistatin-like 1 -0.0277064
TPM1 tropomyosin 1 (alpha) -0.0276896
VDAC1 voltage-dependent anion channel 1 -0.027455
JAZF1 JAZF zinc finger 1 -0.0272721
BTG1 B-cell translocation gene 1, anti-proliferative -0.0270973
MRPS6 mitochondrial ribosomal protein S6 -0.0266817
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0266477
CAVIN1 caveolae associated protein 1 -0.0264212
TNS3 tensin 3 -0.0263572
SDK1 sidekick cell adhesion molecule 1 -0.0262904
WTAP Wilms tumor 1 associated protein -0.0261099
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0260608
FNDC3B fibronectin type III domain containing 3B -0.0260094
GPC6 glypican 6 -0.0259733
MEIS2 Meis homeobox 2 -0.0258921
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0258722
INTS6 integrator complex subunit 6 -0.0258582
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0256244
RPS24 ribosomal protein S24 -0.0254945
RRBP1 ribosome binding protein 1 -0.0254806
LRRC17 leucine rich repeat containing 17 -0.0254215
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0253933
OGA O-GlcNAcase -0.0253899
CHD9 chromodomain helicase DNA binding protein 9 -0.0253869
IFI16 interferon, gamma-inducible protein 16 -0.0250606
HDLBP high density lipoprotein binding protein -0.0250483
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.024795
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.024711
MX2 MX dynamin-like GTPase 2 -0.0245425
FRMD5 FERM domain containing 5 -0.0244925
CAV1 caveolin 1, caveolae protein, 22kDa -0.0244457
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0241479
TRIO trio Rho guanine nucleotide exchange factor -0.0239637
MED13L mediator complex subunit 13-like -0.0234058
IARS1 isoleucyl-tRNA synthetase 1 -0.023289
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0232378