| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Isocorydine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Isocorydine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.269108 |
| TPM3 | tropomyosin 3 | 0.112578 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109557 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0907145 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0775921 |
| PCBP2 | poly(rC) binding protein 2 | 0.0746354 |
| MKI67 | marker of proliferation Ki-67 | 0.0744937 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0744363 |
| RTN4 | reticulon 4 | 0.0734391 |
| DST | dystonin | 0.0722878 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0720118 |
| RPS12 | ribosomal protein S12 | 0.0704653 |
| VMP1 | vacuole membrane protein 1 | 0.0693798 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.067047 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0666738 |
| YAP1 | Yes-associated protein 1 | 0.0638705 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0624909 |
| EGR1 | early growth response 1 | 0.05956 |
| HMGA1 | high mobility group AT-hook 1 | 0.058416 |
| TMEM41B | transmembrane protein 41B | 0.0583789 |
| RRM2 | ribonucleotide reductase M2 | 0.0580701 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0555348 |
| CALR | calreticulin | 0.0546603 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0529327 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0525189 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0523983 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.05181 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0515786 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0512965 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0486718 |
| POTEF | POTE ankyrin domain family, member F | 0.0479937 |
| EDARADD | EDAR-associated death domain | 0.0477678 |
| NLGN1 | neuroligin 1 | 0.0462293 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0460882 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0453967 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0451041 |
| CCN2 | cellular communication network factor 2 | 0.0434567 |
| ENO1 | enolase 1, (alpha) | 0.0410246 |
| PFN1 | profilin 1 | 0.0409199 |
| CMIP | c-Maf inducing protein | 0.0399105 |
| CLTC | clathrin, heavy chain (Hc) | 0.0391572 |
| RPL13A | ribosomal protein L13a | 0.0391164 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0386755 |
| GANAB | glucosidase, alpha; neutral AB | 0.0377789 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0375094 |
| JMJD1C | jumonji domain containing 1C | 0.0367321 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0363549 |
| PDGFC | platelet derived growth factor C | 0.0362978 |
| RPS2 | ribosomal protein S2 | 0.0361374 |
| LDHA | lactate dehydrogenase A | 0.0360522 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0353567 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0350858 |
| ADIPOR2 | adiponectin receptor 2 | 0.0348675 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0346614 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.033331 |
| WWOX | WW domain containing oxidoreductase | 0.0328893 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0326747 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0325385 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0322959 |
| ASPH | aspartate beta-hydroxylase | 0.0321097 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0320881 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0312808 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0307078 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.030471 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0303552 |
| RPL3 | ribosomal protein L3 | 0.0303545 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0298991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0293007 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0288082 |
| NHSL1 | NHS-like 1 | 0.027767 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0277099 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0274352 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0272555 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.026859 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0267844 |
| ATP11A | ATPase, class VI, type 11A | 0.0267543 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0267286 |
| NUP58 | nucleoporin 58 | 0.0265252 |
| YBX1 | Y box binding protein 1 | 0.0265005 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0264985 |
| MAP1B | microtubule-associated protein 1B | 0.0263185 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0261094 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0258708 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0258069 |
| SET | SET nuclear proto-oncogene | 0.0252064 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.025096 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0249014 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0247959 |
| BRD2 | bromodomain containing 2 | 0.0245407 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0244714 |
| RCOR1 | REST corepressor 1 | 0.0244399 |
| ZNF146 | zinc finger protein 146 | 0.0243957 |
| DIAPH3 | diaphanous-related formin 3 | 0.0242807 |
| RPS3 | ribosomal protein S3 | 0.0239068 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0238673 |
| BRD4 | bromodomain containing 4 | 0.0238305 |
| HDGF | hepatoma-derived growth factor | 0.0237876 |
| RPL37A | ribosomal protein L37a | 0.0235323 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0233753 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0232431 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.243403 |
| TMSB10 | thymosin beta 10 | -0.224436 |
| PTMA | prothymosin, alpha | -0.112114 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.100058 |
| FTL | ferritin, light polypeptide | -0.0938034 |
| RPLP1 | ribosomal protein, large, P1 | -0.0933458 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0788475 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0689024 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0673995 |
| RPS24 | ribosomal protein S24 | -0.0544454 |
| GNAS | GNAS complex locus | -0.0493981 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0474887 |
| CLDN1 | claudin 1 | -0.0465353 |
| PCDH7 | protocadherin 7 | -0.0457372 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.044206 |
| RPLP0 | ribosomal protein, large, P0 | -0.043251 |
| S100A6 | S100 calcium binding protein A6 | -0.0430291 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0417272 |
| RPL31 | ribosomal protein L31 | -0.0409939 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0405014 |
| RPL34 | ribosomal protein L34 | -0.0399104 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.037938 |
| MGAT4C | MGAT4 family, member C | -0.0373184 |
| AHNAK | AHNAK nucleoprotein | -0.0364364 |
| ZNF804A | zinc finger protein 804A | -0.0350257 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0343875 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0342323 |
| RPS5 | ribosomal protein S5 | -0.0335802 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0330347 |
| RPL19 | ribosomal protein L19 | -0.0321848 |
| LMO7 | LIM domain 7 | -0.0321238 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0320469 |
| RPS4X | ribosomal protein S4, X-linked | -0.031583 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0314909 |
| TMEM131 | transmembrane protein 131 | -0.0309231 |
| PARK7 | parkinson protein 7 | -0.0302706 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0300879 |
| CCND1 | cyclin D1 | -0.0291962 |
| CDK6 | cyclin-dependent kinase 6 | -0.0291004 |
| NPR2 | natriuretic peptide receptor 2 | -0.0290186 |
| RPS20 | ribosomal protein S20 | -0.0286502 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0286367 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0284888 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0282606 |
| HMGA2 | high mobility group AT-hook 2 | -0.0281221 |
| RPL4 | ribosomal protein L4 | -0.0277929 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0276413 |
| H1-0 | H1.0 linker histone | -0.0276175 |
| RPL32 | ribosomal protein L32 | -0.0272626 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0272303 |
| BCHE | butyrylcholinesterase | -0.0270051 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0267 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0265246 |
| MMP12 | matrix metallopeptidase 12 | -0.0264675 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0264466 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0259468 |
| RPL27A | ribosomal protein L27a | -0.0258835 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0248961 |
| HSPB1 | heat shock 27kDa protein 1 | -0.024839 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0246091 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0245903 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0245176 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0244254 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0243781 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0242031 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0236666 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0234897 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0233643 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0230145 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.0229563 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.022945 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.022888 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0228164 |
| RPS16 | ribosomal protein S16 | -0.0227788 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0225508 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0225427 |
| TUBB | tubulin, beta class I | -0.0224927 |
| PTMS | parathymosin | -0.0222012 |
| KLHL24 | kelch-like family member 24 | -0.0221439 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0220734 |
| RPL12 | ribosomal protein L12 | -0.0219455 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0216083 |
| SEPTIN7 | septin 7 | -0.0209225 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0209038 |
| CBX3 | chromobox homolog 3 | -0.0208658 |
| MED13 | mediator complex subunit 13 | -0.0207927 |
| BTG3 | BTG family, member 3 | -0.0207709 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0204614 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0204547 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0204293 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0203757 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0203381 |
| RPL39 | ribosomal protein L39 | -0.0203217 |
| EHBP1 | EH domain binding protein 1 | -0.0200157 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0199863 |
| RPL14 | ribosomal protein L14 | -0.0199735 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0199258 |
| RPL8 | ribosomal protein L8 | -0.019839 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0198312 |
| SYT1 | synaptotagmin I | -0.0197594 |
