Isocorydine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Isocorydine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.437289
ANTXR1 anthrax toxin receptor 1 0.0582999
PLAT plasminogen activator, tissue 0.0547685
BPTF bromodomain PHD finger transcription factor 0.048894
FMN1 formin 1 0.0482165
MYH9 myosin, heavy chain 9, non-muscle 0.0473517
LSAMP limbic system-associated membrane protein 0.0465542
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0454845
MACF1 microtubule-actin crosslinking factor 1 0.0443977
SLIT2 slit homolog 2 (Drosophila) 0.0440221
TRIO trio Rho guanine nucleotide exchange factor 0.0435639
TLE4 transducin-like enhancer of split 4 0.0410066
HSPA8 heat shock 70kDa protein 8 0.0405279
CEMIP cell migration inducing protein, hyaluronan binding 0.0400935
COL4A2 collagen, type IV, alpha 2 0.0400258
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0398185
THBS1 thrombospondin 1 0.0396451
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0385886
TPST1 tyrosylprotein sulfotransferase 1 0.0373052
RNF213 ring finger protein 213 0.0370717
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0368288
KLF6 Kruppel-like factor 6 0.036782
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0366075
PTPRE protein tyrosine phosphatase, receptor type, E 0.0352192
VCL vinculin 0.0351786
VMP1 vacuole membrane protein 1 0.0348283
FAM107B family with sequence similarity 107, member B 0.0345305
THSD4 thrombospondin, type I, domain containing 4 0.0343831
TPT1 tumor protein, translationally-controlled 1 0.0338943
ARHGAP9 Rho GTPase activating protein 9 0.0331671
SOS1 son of sevenless homolog 1 (Drosophila) 0.0325077
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0318787
RIGI RNA sensor RIG-I 0.0312995
PTPRD protein tyrosine phosphatase, receptor type, D 0.031284
COL1A1 collagen, type I, alpha 1 0.0308316
EGR1 early growth response 1 0.0308273
CTSB cathepsin B 0.0306044
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0291324
EEF1G eukaryotic translation elongation factor 1 gamma 0.0268581
RET ret proto-oncogene 0.0264992
PDE10A phosphodiesterase 10A 0.0264971
EEF2 eukaryotic translation elongation factor 2 0.0262946
AMOTL1 angiomotin like 1 0.0260273
LPP LIM domain containing preferred translocation partner in lipoma 0.0246331
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0245464
DST dystonin 0.0241802
PCBP3 poly(rC) binding protein 3 0.0234295
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0233874
STK38L serine/threonine kinase 38 like 0.0233025
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0231757
TENM4 teneurin transmembrane protein 4 0.0230318
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0227782
EXOC4 exocyst complex component 4 0.02267
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0226621
COL3A1 collagen, type III, alpha 1 0.0218938
EPAS1 endothelial PAS domain protein 1 0.0215165
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0213052
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0211145
TIMP3 TIMP metallopeptidase inhibitor 3 0.0210216
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0208967
CRH corticotropin releasing hormone 0.0207158
SMAD3 SMAD family member 3 0.0205843
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0201484
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0197979
COL18A1 collagen, type XVIII, alpha 1 0.0196572
ANTXR2 anthrax toxin receptor 2 0.0196378
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0195985
FKBP10 FK506 binding protein 10, 65 kDa 0.0195877
GSE1 Gse1 coiled-coil protein 0.019581
CEMIP2 cell migration inducing hyaluronidase 2 0.0194618
MAP1B microtubule-associated protein 1B 0.0193976
SLC38A2 solute carrier family 38, member 2 0.0193204
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0187711
ADAR adenosine deaminase, RNA-specific 0.0186698
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0186415
BABAM2 BRISC and BRCA1 A complex member 2 0.0182636
PTPRM protein tyrosine phosphatase, receptor type, M 0.0180436
IGFBP3 insulin-like growth factor binding protein 3 0.01798
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0179361
AFF3 AF4/FMR2 family, member 3 0.0179209
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0176952
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0174471
PLPP1 phospholipid phosphatase 1 0.0173551
CADM1 cell adhesion molecule 1 0.0173255
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.017281
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0171502
PTPRK protein tyrosine phosphatase, receptor type, K 0.0170191
RGS4 regulator of G-protein signaling 4 0.0170146
FAM171A1 family with sequence similarity 171, member A1 0.0169388
NPAS2 neuronal PAS domain protein 2 0.0168981
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0168439
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0168313
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0165172
DNM3 dynamin 3 0.0164198
SEPTIN9 septin 9 0.0163893
AKAP12 A kinase (PRKA) anchor protein 12 0.016249
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0161572
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0160643
TPM3 tropomyosin 3 0.0159121
CXCL8 chemokine (C-X-C motif) ligand 8 0.0156208

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.345882
PTMA prothymosin, alpha -0.105263
RPLP1 ribosomal protein, large, P1 -0.0642185
VIM vimentin -0.0601462
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0513593
RPS6 ribosomal protein S6 -0.0513113
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0474872
FAM13A family with sequence similarity 13, member A -0.0409462
DPH6 diphthamine biosynthesis 6 -0.0376326
MEIS2 Meis homeobox 2 -0.0375716
NPEPPS aminopeptidase puromycin sensitive -0.0363282
HELZ helicase with zinc finger -0.0360704
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0347806
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0328491
WDR45B WD repeat domain 45B -0.0324405
GOLGA4 golgin A4 -0.0321589
SETD5 SET domain containing 5 -0.0318387
FBXL20 F-box and leucine-rich repeat protein 20 -0.0315348
NDRG1 N-myc downstream regulated 1 -0.0312019
KMT2E lysine (K)-specific methyltransferase 2E -0.0279239
ZNF292 zinc finger protein 292 -0.0278248
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0273346
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271018
RPS24 ribosomal protein S24 -0.0270963
DTNA dystrobrevin, alpha -0.026877
USP3 ubiquitin specific peptidase 3 -0.0264795
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0262611
OGA O-GlcNAcase -0.0262036
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0257425
FTL ferritin, light polypeptide -0.0250336
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0249126
RNF145 ring finger protein 145 -0.0246804
TMSB10 thymosin beta 10 -0.0244837
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0242879
DSTN destrin (actin depolymerizing factor) -0.0239713
RPS19 ribosomal protein S19 -0.023114
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0230239
GNAS GNAS complex locus -0.0225836
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0224624
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.021909
COPA coatomer protein complex, subunit alpha -0.0217679
ANKRD28 ankyrin repeat domain 28 -0.0214783
LCORL ligand dependent nuclear receptor corepressor-like -0.0213036
LPIN1 lipin 1 -0.0212457
GLG1 golgi glycoprotein 1 -0.0205093
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0203431
PHIP pleckstrin homology domain interacting protein -0.0200961
DCAF7 DDB1 and CUL4 associated factor 7 -0.0200754
RPL34 ribosomal protein L34 -0.0196829
TNPO1 transportin 1 -0.0196351
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0195299
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0194444
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0194193
RPL31 ribosomal protein L31 -0.0191478
SEPTIN2 septin 2 -0.0190689
PKM pyruvate kinase, muscle -0.0188745
ZMYM2 zinc finger, MYM-type 2 -0.0185063
RTN4 reticulon 4 -0.0185051
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0184889
VDAC1 voltage-dependent anion channel 1 -0.0184523
SOX9 SRY (sex determining region Y)-box 9 -0.0182697
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0182345
ACBD3 acyl-CoA binding domain containing 3 -0.0180504
PNISR PNN-interacting serine/arginine-rich protein -0.0180253
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0179956
USP34 ubiquitin specific peptidase 34 -0.0177805
SLMAP sarcolemma associated protein -0.0177292
FNDC3B fibronectin type III domain containing 3B -0.0176724
RPL19 ribosomal protein L19 -0.0175567
RBM25 RNA binding motif protein 25 -0.0172982
RPL32 ribosomal protein L32 -0.0172948
KDM3A lysine (K)-specific demethylase 3A -0.0172724
SRP54 signal recognition particle 54kDa -0.0172615
LDHB lactate dehydrogenase B -0.0170396
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0168134
MIS18BP1 MIS18 binding protein 1 -0.0166468
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0166056
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.016564
RPL28 ribosomal protein L28 -0.0165613
NKTR natural killer cell triggering receptor -0.0164401
ESYT2 extended synaptotagmin-like protein 2 -0.0162067
SCAF11 SR-related CTD-associated factor 11 -0.0161781
ZC3H15 zinc finger CCCH-type containing 15 -0.0159329
RPS14 ribosomal protein S14 -0.0159134
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0157257
RAB6A RAB6A, member RAS oncogene family -0.015716
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0156997
RPLP0 ribosomal protein, large, P0 -0.0156744
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0156528
CEP95 centrosomal protein 95kDa -0.0156305
RNF150 ring finger protein 150 -0.0155871
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0153501
RNF24 ring finger protein 24 -0.0151741
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0151615
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0151561
NAP1L1 nucleosome assembly protein 1-like 1 -0.0151303
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0150647
STAG2 stromal antigen 2 -0.0150576
NUP58 nucleoporin 58 -0.0150415
CABIN1 calcineurin binding protein 1 -0.0150299