Isocorydine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Isocorydine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.150449
IGF2 insulin-like growth factor 2 0.123365
SAMD4A sterile alpha motif domain containing 4A 0.113852
SVIL supervillin 0.10993
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.104247
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.102273
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0739941
TIMP1 TIMP metallopeptidase inhibitor 1 0.0683192
GRB10 growth factor receptor-bound protein 10 0.0668065
NDRG1 N-myc downstream regulated 1 0.0633682
TNS1 tensin 1 0.0618204
IGFBP1 insulin-like growth factor binding protein 1 0.0560064
MT2A metallothionein 2A 0.0550037
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0536236
TRIO trio Rho guanine nucleotide exchange factor 0.0489708
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.048639
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0461323
MYH9 myosin, heavy chain 9, non-muscle 0.0428632
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0423851
DSPP dentin sialophosphoprotein 0.0416718
VEGFA vascular endothelial growth factor A 0.0416636
VMP1 vacuole membrane protein 1 0.0412724
SMAD3 SMAD family member 3 0.0408415
FAT1 FAT atypical cadherin 1 0.0378656
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0370486
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0369628
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0369561
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.035851
NUP58 nucleoporin 58 0.0355225
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0354052
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0353465
FLNB filamin B, beta 0.0349816
DTNA dystrobrevin, alpha 0.0338908
RUNX1 runt-related transcription factor 1 0.0333198
DST dystonin 0.0329559
AFDN afadin, adherens junction formation factor 0.0317721
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0313065
SEPTIN9 septin 9 0.0313055
MACF1 microtubule-actin crosslinking factor 1 0.0312847
MYO1B myosin IB 0.0307558
KLF6 Kruppel-like factor 6 0.0306766
CMIP c-Maf inducing protein 0.0299488
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.029406
FMNL2 formin-like 2 0.0292331
KIF1B kinesin family member 1B 0.0291297
FAM107B family with sequence similarity 107, member B 0.028798
ENAH enabled homolog (Drosophila) 0.0287922
ESYT2 extended synaptotagmin-like protein 2 0.028784
LPP LIM domain containing preferred translocation partner in lipoma 0.0285512
KIAA1217 KIAA1217 0.0282313
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0273588
STC2 stanniocalcin 2 0.0259704
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0255661
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0255397
DNAH17 dynein, axonemal, heavy chain 17 0.0254639
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0253846
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0251205
SHB Src homology 2 domain containing adaptor protein B 0.0248957
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0246829
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0245434
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0245197
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0240595
AFF1 AF4/FMR2 family, member 1 0.023742
FLNA filamin A, alpha 0.0235975
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0232185
PCBP2 poly(rC) binding protein 2 0.0231941
PAWR PRKC, apoptosis, WT1, regulator 0.022997
FAM13A family with sequence similarity 13, member A 0.0229337
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0227746
KYNU kynureninase 0.0226617
NAMPT nicotinamide phosphoribosyltransferase 0.0226479
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0225905
LMCD1 LIM and cysteine-rich domains 1 0.0225855
ZMIZ1 zinc finger, MIZ-type containing 1 0.0224908
FAM219A family with sequence similarity 219, member A 0.0222396
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0221826
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0220596
COL7A1 collagen, type VII, alpha 1 0.0216691
NPTN neuroplastin 0.0213475
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0211401
RNF213 ring finger protein 213 0.0211021
WDR1 WD repeat domain 1 0.0210341
DOCK4 dedicator of cytokinesis 4 0.0209943
ARRDC3 arrestin domain containing 3 0.0207627
MYO5B myosin VB 0.0204077
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0200223
FRMD5 FERM domain containing 5 0.0197302
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.019715
RAI14 retinoic acid induced 14 0.0196656
PPARD peroxisome proliferator-activated receptor delta 0.0193602
RAB3B RAB3B, member RAS oncogene family 0.0192377
P4HB prolyl 4-hydroxylase, beta polypeptide 0.01914
MSI2 musashi RNA-binding protein 2 0.0190875
FERMT2 fermitin family member 2 0.0190075
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0188484
BCL2L1 BCL2-like 1 0.0187751
HELZ helicase with zinc finger 0.0187364
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0187336
LIMS1 LIM and senescent cell antigen-like domains 1 0.0187063
CDC7 cell division cycle 7 0.0186118

decreased expression

Symbol Name Standardized Value
GPC3 glypican 3 -0.137141
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133477
APOB apolipoprotein B -0.131923
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.127853
TPT1 tumor protein, translationally-controlled 1 -0.112973
RPS6 ribosomal protein S6 -0.108615
ERRFI1 ERBB receptor feedback inhibitor 1 -0.10856
AHSG alpha-2-HS-glycoprotein -0.1081
SLC38A2 solute carrier family 38, member 2 -0.0993608
APOA2 apolipoprotein A-II -0.0936347
RPS24 ribosomal protein S24 -0.0935783
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0925441
RPS8 ribosomal protein S8 -0.0924257
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0871429
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.083226
TM4SF1 transmembrane 4 L six family member 1 -0.0830986
PLIN2 perilipin 2 -0.0828114
RPL37A ribosomal protein L37a -0.0801991
CP ceruloplasmin (ferroxidase) -0.0778039
FBF1 Fas (TNFRSF6) binding factor 1 -0.0773957
AKAP12 A kinase (PRKA) anchor protein 12 -0.0767867
RPS12 ribosomal protein S12 -0.0748339
EML4 echinoderm microtubule associated protein like 4 -0.0726799
FNDC3B fibronectin type III domain containing 3B -0.0703717
TRIM26 tripartite motif containing 26 -0.0685887
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0649634
PEG3 paternally expressed 3 -0.0635145
A2M alpha-2-macroglobulin -0.0622003
TMSB10 thymosin beta 10 -0.0613695
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0599906
EHBP1 EH domain binding protein 1 -0.0575119
RACK1 receptor for activated C kinase 1 -0.0562149
MBNL3 muscleblind-like splicing regulator 3 -0.0550864
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0545524
RPL34 ribosomal protein L34 -0.0508378
NPR2 natriuretic peptide receptor 2 -0.0507092
RPL31 ribosomal protein L31 -0.0501963
ENO1 enolase 1, (alpha) -0.0500906
C3 complement component 3 -0.0495412
RPS27A ribosomal protein S27a -0.0486855
RPL35A ribosomal protein L35a -0.0482048
RPL9 ribosomal protein L9 -0.0478269
RPLP0 ribosomal protein, large, P0 -0.0476164
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0473287
ELL2 elongation factor, RNA polymerase II, 2 -0.0470458
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0456439
ARL5A ADP-ribosylation factor-like 5A -0.045541
AMBP alpha-1-microglobulin/bikunin precursor -0.0450519
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0450355
PTMA prothymosin, alpha -0.0443995
RPS19 ribosomal protein S19 -0.0433355
PTCHD4 patched domain containing 4 -0.041927
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0416474
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0413934
CPE carboxypeptidase E -0.0411392
RPS17 ribosomal protein S17 -0.040877
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0406122
ARHGAP5 Rho GTPase activating protein 5 -0.0404198
RPL11 ribosomal protein L11 -0.0391875
GMDS GDP-mannose 4,6-dehydratase -0.039184
LYZ lysozyme -0.0391641
MAML2 mastermind-like 2 (Drosophila) -0.0386987
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0385738
TMEM123 transmembrane protein 123 -0.0384373
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0383892
NCOA7 nuclear receptor coactivator 7 -0.0380268
RPL26 ribosomal protein L26 -0.0374808
ACTG1 actin gamma 1 -0.0373542
RPLP2 ribosomal protein, large, P2 -0.0373321
RPL12 ribosomal protein L12 -0.0372198
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.036763
RPS14 ribosomal protein S14 -0.0364857
SLC38A1 solute carrier family 38, member 1 -0.0362297
RPS13 ribosomal protein S13 -0.0361884
ZMYND8 zinc finger, MYND-type containing 8 -0.0359563
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0356538
RPLP1 ribosomal protein, large, P1 -0.0356213
ISG15 ISG15 ubiquitin-like modifier -0.0353821
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0353809
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0353044
CALD1 caldesmon 1 -0.0352658
RPS25 ribosomal protein S25 -0.0347162
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0346763
TPM4 tropomyosin 4 -0.0346334
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0345882
TAS2R14 taste receptor, type 2, member 14 -0.0343083
APOE apolipoprotein E -0.0342558
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0340346
ZBTB20 zinc finger and BTB domain containing 20 -0.0337325
RPL37 ribosomal protein L37 -0.0336305
RPS5 ribosomal protein S5 -0.0332644
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0329933
NPAS2 neuronal PAS domain protein 2 -0.0329619
NKD1 naked cuticle homolog 1 (Drosophila) -0.0329329
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0327827
SOX5 SRY (sex determining region Y)-box 5 -0.032681
RPL4 ribosomal protein L4 -0.0325312
PRRC2C proline-rich coiled-coil 2C -0.0324819
RPS21 ribosomal protein S21 -0.0322857
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0321278